Regulation of osteoclast-mediated bone resorption by lipids

Bone, Journal Year: 2025, Volume and Issue: 193, P. 117423 - 117423

Published: Feb. 9, 2025

Language: Английский

---

The relationship between non-HDL-C/HDL-C ratio and bone mineral density: an NHANES study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

The non-high-density lipoprotein cholesterol to high-density ratio (NHHR) is a newly developed lipid parameter. However, the current research has only explored relationship with lumbar spine bone mineral density, lacking studies on density at other sites, total body and an analysis of risk factors. This study aims determine potential association between NHHR BMD, increase awareness impact levels health. By utilizing data from National Health Nutrition Examination Survey (NHANES) 2011 2018, we conducted univariate generalized linear models (GLMs) analysis, stratified threshold effect smooth curve fitting investigate BMD. were categorized into tertiles (low, medium, high) based their distribution among population. included 8,671participants, have shown, exhibits correlation (BMD). In BMI subgroup, significantly negatively correlated BMD multiple sites in low-to-middle group (BMI <25 kg/m2), while no significant found high ≥30 kg/m2). gender more pronounced male mainly reflected reduction age negative strongest younger (18-30 years), gradually weakening middle-aged (31-44 years) older groups (45-59 years). Further suggests that dyslipidemia may influence metabolism through pathways such as inflammation oxidative stress. (BMD) varies by BMI, gender, age. controlling be intervention target for health management, particularly individuals males, populations. These findings offer new perspective provide scientific evidence development personalized osteoporosis prevention treatment strategies.

Language: Английский

---

A review of pharmacological mechanisms, challenges and prospects of macromolecular glycopeptides

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140294 - 140294

Published: Jan. 1, 2025

Language: Английский

---

The bone-vascular axis: the link between osteoporosis and vascular calcification

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

---

Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 30, 2025

Language: Английский

---

The association of lipids and novel non-statin lipid-lowering drug target with osteoporosis: evidence from genetic correlations and Mendelian randomization

BMC Musculoskeletal Disorders, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 1, 2025

It remains controversial whether lipids affect osteoporosis (OP) or bone mineral density (BMD), and causality has not been established. This study aimed to investigate the genetic associations between lipids, novel non-statin lipid-lowering drug target genes, OP BMD. Mendelian randomization (MR) method was used explore 179 lipid species OP, Drug-target MR analysis causal angiopoietin-like protein 3 (ANGPTL3) apolipoprotein C3 (APOC3) inhibitors on The IVW results with Bonferroni correction indicated that triglyceride (TG) (51:3) (OR = 1.0029; 95% CI: 1.0014–1.0045; P 0.0002) TG (56:6) 1.0021; 1.0008–1.0033; 0.0011) were associated an increased risk of OP; (51:2) 0.9543; 0.9148–0.9954; 0.0298) decreased BMD; ANGPTL3 inhibitor 1.1342; 1.0393–1.2290; 0.0093) APOC3 1.0506; 1.0155–1.0857; 0.0058) genetically predicted TGs showed have potential serve as targets treat prevent OP.

Language: Английский

---

Identification of endoplasmic reticulum stress and mitochondrial dysfunction related biomarkers in osteoporosis

Hereditas, Journal Year: 2025, Volume and Issue: 162(1)

Published: Feb. 14, 2025

Abstract Background Endoplasmic reticulum stress (ERS) and mitochondrial dysfunction (MD) involved in bone metabolism disorders. However, the particular mechanisms of ERS MD related genes (ERS&MDRGs) osteoporosis (OP) have not been elucidated. In present study, biomarkers to OP were identified. Methods Differentially expressed (DEGs) obtained based on GEO dataset. ERS&MDRGs derived from Genecard database. Initially, ERS&MD DEGs (ERS&MDRDEGs) by overlapping ERS&MDRGs. The key module was screened WGCNA. intersection ERS&MDRDEGs machine learning obtain genes. Then, receiver operating characteristic curve (ROC) drawn calculated diagnostic accuracy ssGSEA Cibersort algorithms performed analyze immune cell infiltration. miRNA-mRNA-TF network draw cytoscape software. Moleculaer docking DGIdb database employed for screening potential drugs. Finally, expression verified qRT-PCR. Results 122 preliminary screening. mainly enriched lipid metabolism, calcium ion transport, ossification. 5 identified, including AAAS , ESR1 SLC12A2 TAF15 VAMP2 . Immune infiltration analysis showed monocyte macrophage different between control groups. regulatory indicated has-miR-625-5p, has-miR-296-3p, CTCT EP300 as targets. 2 small molecule drugs, namely bumetanide elacestrant screened. higher, lower than group. Conclusion This research identified Bumetanide These findings provided valuable insights into pathophysiology development new therapeutic strategies.

Language: Английский

---

Impact of Advanced Platelet-Rich Fibrin on Early Bone Healing After Endodontic Microsurgery: A Randomized Controlled Trial

Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 516 - 516

Published: Feb. 20, 2025

Background: Apical surgery can address periapical pathologies when conventional endodontic treatments fail. Advanced platelet-rich fibrin (A-PRF) has emerged as a regenerative material with the potential to enhance healing in surgery. In this study, we evaluated effect of A-PRF on lesion using cone beam computed tomography (CBCT). Methods: A randomized controlled trial at Rīga Stradiņš University Institute Stomatology included 43 participants (15 males, 28 females; mean age: 44 years) periradicular lesions. Participants were divided into experimental and control groups. Baseline follow-up CBCT imaging assessed volumes 6 12 months post-surgery. Results: Mean significantly decreased from 431.4 mm3 baseline 102.8 49.2 (p < 0.001). did not reduce sizes compared controls = 0.043), but was associated reduced inflammation enhanced soft tissue healing. Key confounders gender volume, males exhibiting smaller postoperatively. Conclusions: The results suggest that may offer significant advantage terms reducing defect size or improving radiographic resolution.

Language: Английский

---

Therapeutic potential of total flavonoids of Rhizoma Drynariae: inhibiting adipogenesis and promoting osteogenesis via MAPK/HIF-1α pathway in primary osteoporosis

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 11, 2025

This study seeks to confirm the therapeutic effectiveness of TRFD in inhibiting adipogenesis and promoting osteogenesis primary osteoporosis through MAPK/HIF-1α signaling pathway. C57BL/6J mice underwent ovariectomy (OVX) induce osteoporosis. Mice were administered (Low high doses)estradiol for a duration 12 weeks. Bone microarchitecture evaluated using Micro-CT, while serum biomarkers protein expressions analyzed enzyme-linked immunosorbent assay, Western blotting, immunohistochemistry. Furthermore, BMSC isolated show differentiation, Osteogenic adipogenic induction performed, including ALP activity Oil Red O staining. Bioinformatics analysis RNA sequencing data was conducted identify differentially expressed genes. Total flavonoids Rhizoma Drynariae treatment significantly improved bone reversed histopathological damage OVX mice. It increased levels markers (RUNX2, BMP-2) enhanced MAPK HIF-1α pathways, The results also showed significant dose, TFDR osteogenic differentiation BMSCs suppressing as demonstrated by mineralization, alongside, expression lipid (PPAR-γ, C/EBPα) inhibited. pathway confirmed be crucial mediating these effects. exhibits potential treating These establish an investigation natural option managing Not applicable.

Language: Английский

---

Diverse Bone Matrix and Mineral Alterations in Osteoporosis with Different Causes: A Solid-State NMR Study

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Osteoporosis (OP), which is a common skeletal disease with different causes, prevalent in the aging population. Postmenopause women generally suffer from OP bone loss due to estrogen deficiency. Diabetes also associated by complex metabolic mechanisms. Bone qualities of caused were compared those ovariectomy (OVX) model and Type 2 diabetic using Sprague–Dawley (SD) rats our study. Combining micro-computed tomography (μ-CT) solid-state NMR (SSNMR) methods, this research studied changes SD tissue level molecular level. The studies revealed was most significant for cancellous bones but not cortical rats. However, at level, content HAP increased aging, contributing brittleness bone. Triglyceride, as senescence maker osteocyte bone, identified be closely OVX This suggests that quality more objectively reflect reconstruction various causes rather than mere μ-CT analysis.

Language: Английский

---