International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12405 - 12405
Published: Nov. 19, 2024
Long-term
treatment
with
bisphosphonates
is
accompanied
by
an
increased
risk
of
medication-related
osteonecrosis
the
jaw
(MRONJ).
Currently,
no
clinically
useful
biomarkers
for
predictive
diagnosis
MRONJ
are
available.
To
investigate
potential
key
proteins
involved
in
pathogenesis
MRONJ,
a
proteomic
LC-MS/MS
analysis
saliva
was
performed.
Differentially
expressed
(DEPs)
were
analyzed
using
BiNGO,
ClueGO,
cytoHubba,
MCODE,
KEGG,
and
ReactomeFI
software
packages
Cytoscape
platforms.
In
total,
1545
DEPs
identified,
including
43
up-
11
down-regulated
1.5-fold
cut-off
value
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
Abstract
Background
The
ratio
of
non-high-density
lipoprotein
cholesterol
to
high-density
(NHHR)
represents
a
novel
lipid
marker.
This
study
investigated
the
association
between
NHHR
and
lumbar
bone
mineral
density
(BMD)
in
general
American
population.
Methods
Data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
spanning
2011
2018
were
used
this
study,
including
10,879
participants
aged
20–59
years.
To
investigate
relationship
BMD,
we
employed
multivariate
linear
regression
models
along
with
stratified
analyses.
Additionally,
applied
fitted
smoothing
curves
threshold
effect
analyses
explore
nonlinear
BMD.
Results
After
adjusting
for
covariates,
weighted
multivariable
indicated
significant
negative
(β
=
-0.006,
95%
CI:
-0.008
-0.003,
P
<
0.001).
Stratified
subgroup
based
on
age,
gender,
race,
BMI,
hypertension,
diabetes
consistently
demonstrated
inverse
males
-0.005,
-0.002,
0.002)
females
-0.007,
-0.011
0.001);
non-Hispanic
whites
-0.009
-0.001,
0.015),
blacks
-0.010,
-0.017
-0.004,
0.003),
other
races
20–29
years
0.022)
40–49
-0.008,
-0.013
individuals
BMI
25
-0.014
0.010)
those
30
-0.011,
-0.015
For
total
cohort,
races,
30–39
years,
was
examined
inflection
points
identified
at
values
4.29,
5.26,
2.91,
respectively.
Conclusions
US
adults
20
59,
our
research
an
observed
across
demonstrating
Consequently,
could
serve
as
sensitive
biomarker
prevention
osteoporosis
or
osteopenia.
Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(11), P. 1135 - 1135
Published: Nov. 11, 2024
Non-unions
are
fractures
that
do
not
heal
properly,
resulting
in
a
false
joint
formation
at
the
fracture
site.
This
condition
leads
to
major
health
issues
and
imposes
burden
on
national
healthcare
systems.
The
etiology
of
non-unions
is
still
fully
understood;
therefore,
we
aimed
identify
potential
systemic
factors
may
contribute
their
formation.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12405 - 12405
Published: Nov. 19, 2024
Long-term
treatment
with
bisphosphonates
is
accompanied
by
an
increased
risk
of
medication-related
osteonecrosis
the
jaw
(MRONJ).
Currently,
no
clinically
useful
biomarkers
for
predictive
diagnosis
MRONJ
are
available.
To
investigate
potential
key
proteins
involved
in
pathogenesis
MRONJ,
a
proteomic
LC-MS/MS
analysis
saliva
was
performed.
Differentially
expressed
(DEPs)
were
analyzed
using
BiNGO,
ClueGO,
cytoHubba,
MCODE,
KEGG,
and
ReactomeFI
software
packages
Cytoscape
platforms.
In
total,
1545
DEPs
identified,
including
43
up-
11
down-regulated
1.5-fold
cut-off
value
