Mechanical Modulation, Physiological Roles, and Imaging Innovations of Intercellular Calcium Waves in Living Systems DOI Open Access

Cole Mackey,

Yuning Feng,

Chenyu Liang

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(11), P. 1851 - 1851

Published: May 31, 2025

Long-range intercellular communication is essential for multicellular biological systems to regulate multiscale cell–cell interactions and maintain life. Growing evidence suggests that calcium waves (ICWs) act as a class of long-range signals influence broad spectrum cellular functions behaviors. Importantly, mechanical signals, ranging from single-molecule-scale tissue-scale in vivo, can initiate modulate ICWs addition relatively well-appreciated biochemical bioelectrical signals. Despite these recent conceptual experimental advances, the full nature underpinning mechanotransduction mechanisms by which cells convert into ICW dynamics remains poorly understood. This review provides systematic analysis quantitative around three main stages: initiation, propagation, regeneration/relay. We highlight landscape upstream molecules organelles sense respond stimuli, including mechanosensitive membrane proteins cytoskeletal machinery. clarify roles downstream molecular networks mediate signal release, spread, amplification, adenosine triphosphate (ATP) purinergic receptor activation, gap junction (GJ) communication. Furthermore, we discuss pathophysiological implications ICWs, covering processes such cancer metastasis, tissue repair, developmental patterning. Finally, summarize advances optical imaging artificial intelligence (AI)/machine learning (ML) technologies reveal precise spatial-temporal-functional ATP waves. By synthesizing insights, offer comprehensive framework mechanobiology propose new directions mechano-therapeutic strategies disease diagnosis, immunotherapies, drug discovery.

Language: Английский

Mechanical Modulation, Physiological Roles, and Imaging Innovations of Intercellular Calcium Waves in Living Systems DOI Open Access

Cole Mackey,

Yuning Feng,

Chenyu Liang

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(11), P. 1851 - 1851

Published: May 31, 2025

Long-range intercellular communication is essential for multicellular biological systems to regulate multiscale cell–cell interactions and maintain life. Growing evidence suggests that calcium waves (ICWs) act as a class of long-range signals influence broad spectrum cellular functions behaviors. Importantly, mechanical signals, ranging from single-molecule-scale tissue-scale in vivo, can initiate modulate ICWs addition relatively well-appreciated biochemical bioelectrical signals. Despite these recent conceptual experimental advances, the full nature underpinning mechanotransduction mechanisms by which cells convert into ICW dynamics remains poorly understood. This review provides systematic analysis quantitative around three main stages: initiation, propagation, regeneration/relay. We highlight landscape upstream molecules organelles sense respond stimuli, including mechanosensitive membrane proteins cytoskeletal machinery. clarify roles downstream molecular networks mediate signal release, spread, amplification, adenosine triphosphate (ATP) purinergic receptor activation, gap junction (GJ) communication. Furthermore, we discuss pathophysiological implications ICWs, covering processes such cancer metastasis, tissue repair, developmental patterning. Finally, summarize advances optical imaging artificial intelligence (AI)/machine learning (ML) technologies reveal precise spatial-temporal-functional ATP waves. By synthesizing insights, offer comprehensive framework mechanobiology propose new directions mechano-therapeutic strategies disease diagnosis, immunotherapies, drug discovery.

Language: Английский

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