Molecular pathway approach in biotechnology DOI
Anton Buzdin,

Denis Kuzmin,

Ivana Jovčevska

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 339 - 352

Published: Dec. 6, 2024

Language: Английский

Polysaccharides from Semen Plantaginis Regulates the CircularTTC3/microRNA-27a-3p Axis to Alleviate Myocardial Cell Hypoxia/Reoxygenation Injury DOI Creative Commons

Binwang Lv,

Yiqun Teng,

Xu Zhang

et al.

Indian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 86(2)

Published: Jan. 1, 2024

This work was performed to analyze the effect of polysaccharides from semen plantaginis on myocardial cell hypoxia/reoxygenation injury as well its molecular mechanism. Rat cells H9C2 were exposed various concentrations and then subjected transfection and/or treatment, dividing into control, hypoxia/reoxygenation, hypoxia/reoxygenation+L-plantaginis, hypoxia/reoxygenation+M-plantaginis, hypoxia/reoxygenation+H-plantaginis, hypoxia/reoxygenation+si-circTTC3, hypoxia/reoxygenation+si-negative hypoxia/reoxygenation+plantaginis+plasmid cloning deoxyribonucleic acid-circTTC3 groups. Cell viability detected by 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide assay. Flow cytometry, Western blotting enzyme-linked immunosorbent assays used apoptosis or oxidative stress. CircTTC3 microRNA-27a-3p levels real-time quantitative polymerase chain reaction. The targeting relationship between circTTC3 examined dual-luciferase reporter Treatment with different increased induced superoxide dismutase activity but decreased rate, cleaved caspase-3 expression levels, malondialdehyde content, lactate dehydrogenase in a concentration-dependent manner, accompanied decrease increase (p<0.05). targeted microRNA-27a-3p, inhibition content Overexpression reversed caused damage. Plantaginis regulates circTTC3/microRNA-27a-3p axis attenuate injury.

Language: Английский

Citations

0
Involvement of circ_0029407 in Caerulein-Evoked Cytotoxicity in Human Pancreatic Cells via the miR-579-3p/TLR4/NF-κB Pathway DOI

LU Xingwen,

Caiyan Shi,

Cunlin Fan

et al.

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: May 16, 2024

Language: Английский

Citations

0
Importance of biological markers in the assessment of endothelial dysfunction DOI Creative Commons

Yu. S. Timofeev,

М. А. Михайлова,

О. Н. Джиоева

et al.

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2024, Volume and Issue: 23(9), P. 4061 - 4061

Published: Oct. 24, 2024

Endothelial dysfunction (ED) is a pathogenetic link in many cardio­vas­cular diseases. One of the promising approaches to non-invasi­ve diagnostics and assessment ED severity may be deter­mi­nation specific blood biomarkers. This review devoted patho­genetic role some biochemical molecular factors associated with ED, as potential biomarkers noncommunicable

Language: Английский

Citations

0
Getting started with the molecular pathway analysis DOI
Anton Buzdin, Xinmin Li

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 179 - 202

Published: Dec. 6, 2024

Language: Английский

Citations

0
Molecular data for the pathway analysis DOI
Xinmin Li, Anton Buzdin

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 43 - 62

Published: Dec. 6, 2024

Language: Английский

Citations

0
Molecular pathway approach in biotechnology DOI
Anton Buzdin,

Denis Kuzmin,

Ivana Jovčevska

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 339 - 352

Published: Dec. 6, 2024

Language: Английский

Citations

0