LncRNA HOTAIR promotes aerobic glycolysis by recruiting Lin28 to induce inflammation and apoptosis in acute lung injury

RNA Biology, Journal Year: 2025, Volume and Issue: 22(1), P. 1 - 12

Published: March 7, 2025

Acute lung injury (ALI) is a life-threatening condition with high rates of morbidity and mortality. Recently, there has been growing evidence suggesting link between lncRNA HOTAIR ALI. Nonetheless, the precise role mechanism in ALI remain to be fully elucidated. siHOTAIR transfection, qPCR detection (HOTAIR), ELISA (TNF-α, IL-6, IL-1β), Lactate detection, Glucose uptake experiment, Cell Apoptosis Analysis, Fluorescence situ hybridization (FISH) assay. Through we discovered that plays secretion inflammatory factors further regulates glucose metabolism epithelial cells. Moreover, comparison knockdown cells overexpression revealed promotes cellular aerobic sugar metabolism, leading increased cell apoptosis. Our in-depth research also identified an interaction LIN28 protein. Knocking down resulted downregulation protein expression, which subsequently inhibited expression transporter GLUT1. This indicates facilitates boosts glycolysis by modulating protein, thereby promoting inflammation apoptosis acute injury. The findings presented this article offer significant insights into function suggest potential therapeutic target for treatment condition.

Language: Английский

LncRNA in gastric cancer drug resistance: deciphering the therapeutic strategies

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 1, 2025

Gastric cancer (GC) is an exceedingly aggressive disease and ranks as the third leading cause of cancer-related deaths, which poses a huge health burden globally. Chemotherapy commonly employed during middle to advanced stages cancer, although it faces frequent treatment failures attributed drug resistance. Thus, imperative for researchers identify potential targets overcoming therapeutic resistance, thereby facilitating development novel anti-cancer agents GC patients with stages. Long noncoding RNAs (lncRNAs) are diverse group transcripts limited protein-coding capacity, have been recognized functional molecules regulating progression including cell proliferation, metastasis, resistance in GC. In this review, we examine intricate molecular networks on role lncRNAs LncRNAs conferred through various mechanisms, therefore functioning promising patients. Additionally, discuss current advancements strategies targeting therapy, may pave way lncRNA-mediated precision medicine malignant disease.

Language: Английский