Walking and Hippocampal Formation Volume Changes: A Systematic Review

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(1), P. 52 - 52

Published: Jan. 8, 2025

Sustaining the human brain's hippocampus from atrophy throughout ageing is critical. Exercise proven to be effective in promoting adaptive hippocampal plasticity, and has a bidirectional relationship with physical environment. Therefore, this systematic review explores effects of walking, simple activity environment, on formation volume changes for lifelong brain cognitive health. PubMed, Scopus, Web Science were searched studies humans published up November 2022 examining walking. Twelve met inclusion criteria. Study quality was assessed using PEDro scale ROBINS-I tool. A narrative synthesis explored walking factors associated total, subregional, hemisphere-specific changes. Overall, had positive volumes. Several found benefits higher-intensity greater amounts total volume. The subiculum increased after low-intensity nature exposure, while parahippocampal gyrus benefited vigorous intensity. right spatial navigation during No examined effect dentate gyrus. This highlights as multifaceted variable that can lead manifold These findings support promotion simple, strategy enhance health prevent decline, suggesting design environments natural biophilic characteristics layouts walkability stimulation. Future research encouraged explore subregional instead focusing volume, since multicompartmental subfields respond differently different walking-related variables.

Language: Английский

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Effects of exercise on older adults with mild cognitive impairment: A systematic review and network meta-analysis

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Background: Mild cognitive impairment (MCI) represents a transitional stage between normal aging and Alzheimer's disease (AD), with significantly elevated risk of progressing to AD. In recent years, accumulating evidence has indicated that exercise interventions may mitigate decline in individuals MCI reduce the conversion AD, potentially through mechanisms such as enhancing cerebral blood flow promoting neuroplasticity. Objective: To explore which type is most effective improving global cognition older adults investigate whether can enhance their balance abilities. Methods: Randomized controlled trials were retrieved from four databases. Stata software was used for Network Meta-Analysis traditional meta-analysis. Results: A total 33 studies included, 28 determine best modality. The results multicomponent (SUCRA = 76.5%) moderate-intensity aerobic 73.6%) are two modalities. meta-analysis showed combined training, exercise, resistance land-based kayaking training improve ability. Conclusions: Multicomponent be optimal modality MCI, various modalities However, more larger sample sizes higher quality needed provide further evidence.

Language: Английский

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Mapping the scientific research on exercise therapy for Alzheimer’s disease: a scientometric study of hotspots and emerging trends

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 3, 2025

Background Alzheimer’s disease (AD) is the most common form of dementia globally, placing a substantial economic burden on patients and society. Exercise serves as an adjuvant therapy for AD with low incidence related adverse events. As non-pharmacological intervention, it has demonstrated significant potential in AD. Objective This study examines key hotspots emerging trends exercise AD, offering valuable insights researchers engaged future research this field. Methods The Web Science Core Collection database was utilized to search literature from January 1, 2000, November 2024, 1,372 relevant articles being identified. And CiteSpace 6.2.R4 VOSviewer were used evaluate bibliometric indicators. Results Since number publications field been increasing. In addition well-known areas research, such impact cognitive function, combination medication therapy, effects specific symptoms, music may also focus more novel topics. These include integration design implementation interventions, dendritic spines, neurophysiological mechanisms. Furthermore, analysis keywords reveals that current main direction exploring physiological mechanisms through which affects includes three trends: impairment patients, brain-derived neurotrophic factor (BDNF) Amyloid beta, influence Stress neuroinflammation. Conclusion results indicate interventions using alleviate negative symptoms well combining are gaining increasing attention researchers. Meanwhile, topics should attract scholarly interest. Additionally, behind could be research.

Language: Английский

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Research progress on resistance exercise therapy for improving cognitive function in patients with AD and muscle atrophy

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 8, 2025

Alzheimer's disease (AD) significantly reduces the quality of life patients and exacerbates burden on their families society. Resistance exercise enhances overall cognitive function elderly with AD while positively improving memory, executive function, muscle strength, reducing fall risks, alleviating psychological symptoms. As is a neurodegenerative disorder, some nerve factors are readily activated released during exercise. Therefore, several prior studies have concentrated exploring molecular mechanisms resistance impact brain neural plasticity. Recent investigations identified an intrinsic relationship between individuals pathological skeletal atrophy, establishing correlation level content. primarily targets muscle, which improves impairment in by vascular neuroinflammatory further restoring structural muscle. Furthermore, effects training vary among distinct subgroups impairment. Individuals exhibiting lower demonstrate more pronounced adaptive responses physical performance over time. Consequently, investigation warranted to determine whether tailored guidelines—such as variations frequency duration exercise—should be established for varying levels dementia, order optimize benefits those experiencing This study aimed review atrophy cognition, mechanism cognition through improvement, optimal mode elucidate additional advantages treating atrophy.

Language: Английский

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Sirtuin Proteins and Memory: A Promising Target in Alzheimer’s Disease Therapy?

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4088 - 4088

Published: Nov. 27, 2024

Sirtuins (SIRTs), nicotine adenine dinucleotide (+)-dependent histone deacetylases, have emerged as critical regulators in many signalling pathways involved a wide range of biological processes. Currently, seven mammalian SIRTs been characterized and are found across number cellular compartments. There has considerable interest the role brain due to their plethora metabolic- age-related diseases, including involvement learning memory function physiological pathophysiological conditions. Although cognitive declines over course healthy ageing, neurological disorders Alzheimer's disease (AD) can be associated with progressive impairments. This review aimed report integrate recent advances understanding dysfunction context AD. We also reviewed use selective and/or natural SIRT activators potential therapeutic agents adjuvants for

Language: Английский

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