Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: 154, P. 314 - 348
Published: Oct. 22, 2024
Language: Английский
Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 557 - 557
Published: March 1, 2025
Antimicrobial resistance (AMR) is a growing global health crisis that threatens the efficacy of antibiotics and modern medical interventions. The emergence multidrug-resistant (MDR) pathogens, exacerbated by misuse in healthcare agriculture, underscores urgent need for innovative solutions. (1) Background: AMR arises from complex interactions between human, animal, environmental health, further aggravated overuse inadequate regulation antibiotics. Conventional treatments are increasingly ineffective, necessitating alternative strategies. Emerging approaches, including bacteriophage therapy, antimicrobial peptides (AMPs), nanotechnology, microbial extracellular vesicles (EVs), CRISPR-based antimicrobials, provide novel mechanisms complement traditional combating resistant pathogens. (2) Methods: This review critically analyzes advanced antibacterial strategies conjunction with systemic reforms such as stewardship programs, One Health framework, surveillance tools. These methods can enhance detection, guide interventions, promote sustainable practices. Additionally, economic, logistical, regulatory challenges impeding their implementation evaluated. (3) Results: technologies, CRISPR exhibit promising potential targeting mechanisms. However, disparities resource distribution barriers hinder widespread adoption. Public–private partnerships agriculture practices critical to overcoming these obstacles. (4) Conclusions: A holistic integrated approach essential mitigating impact AMR. By aligning therapeutic policies, fostering interdisciplinary collaboration, ensuring equitable distribution, we develop response this 21st-century challenge.
Language: Английский
Citations
1
Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34692 - e34692
Published: July 1, 2024
The emergence and development of antibiotic resistance in bacteria is a serious threat to global public health. Antibiotic genes (ARGs) are often located on mobile genetic elements (MGEs). They can be transferred among by horizontal gene transfer (HGT), leading the spread drug-resistant strains treatment failure. CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated genes) one many strategies have developed under long-term selection pressure restrict HGT. CRISPR-Cas systems exist about half bacterial genomes play significant role limiting resistance. On other hand, bacteriophages MGEs encode wide range anti-CRISPR proteins (Acrs) counteract immunity system. Acrs could decrease system's activity against phages facilitate acquisition ARGs virulence traits for bacteria. This review aimed assess relationship between with We also highlighted technology control prevent antibacterial system target nucleic acid sequences high accuracy reliability; therefore, it has become novel editing therapy tool CRISPR-based approaches may pave way developing smart antibiotics, which eliminate multidrug-resistant (MDR) distinguish pathogenic beneficial microorganisms. Additionally, engineered gene-containing combination antibiotics used as cutting-edge approach reduce
Language: Английский
Citations
7
Infection and Drug Resistance, Journal Year: 2024, Volume and Issue: Volume 17, P. 5229 - 5245
Published: Nov. 1, 2024
Antimicrobial resistance (AMR) is a critical global health concern that threatens the efficacy of existing antibiotics and poses significant challenges to public economy worldwide. This review explores potential CRISPR-Cas systems as novel approach combating AMR examines current applications, limitations, prospects.
Language: Английский
Citations
5
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1542 - 1542
Published: Dec. 2, 2024
The demand for developing novel antimicrobial drugs has increased due to the rapid appearance and global spread of antibiotic resistance. Antimicrobial peptides (AMPs) offer distinct advantages over traditional antibiotics, such as broad-range efficacy, a delayed evolution resistance, capacity enhance human immunity. AMPs are being developed potential medicines, current computational experimental tools aim facilitate their preclinical clinical development. Structural functional constraints well more stringent regulatory framework have impeded translation possible therapeutic agents. Although around four thousand been identified so far, there some limitations using these in trials safety host sometimes biosynthesis or chemical synthesis AMPs. Overcoming obstacles may help open new era combat superbugs without synthetic antibiotics. This review describes classification, mechanisms action immune modulation, advantages, difficulties, opportunities against multidrug-resistant pathogens highlights need priorities creating targeted development strategies that take into account most cutting-edge currently available. It also barriers trials.
Language: Английский
Citations
5
Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(3)
Published: Feb. 14, 2025
Language: Английский
Citations
0
Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102304 - 102304
Published: April 1, 2025
Language: Английский
Citations
0
BioMed, Journal Year: 2024, Volume and Issue: 4(3), P. 318 - 337
Published: Sept. 5, 2024
Overuse or misuse of broad-spectrum antibiotics increases the risk emergence antibiotic-resistant bacteria, which possibility antimicrobial-resistant (AMR) bacterial infections, and subsequently raises healthcare costs. The excessive use has also been linked to increased death rates, whilst benefits that they offer against pathogens are minimal. Patients infected with frequently receive inadequate antimicrobial therapies due a lack effective options than those non-resistant resulting in poor health outcomes longer recovery times, especially among patients who critically ill. Broad-spectrum disturb gut microbiome, is increasingly recognized as regulator immune health. This study offers insights into targeted for focusing on strategies mitigate antibiotic resistance unwanted side effects associated antibiotics. We focus identifying genotype phenotype then using either nanoparticle-based, vaccine-based, bacteriophage-based, monoclonal antibody-based, CRISPR-based directly kill reduce collateral damage. Furthermore, mechanisms action these their advantages disadvantages discussed.
Language: Английский
Citations
1
Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: March 14, 2024
Language: Английский
Citations
0
Journal of Macromolecular Science Part A, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 7
Published: Oct. 24, 2024
This study focuses on synthesis and characterization of hexa-substituted coumarin based Schiff base derivative cyclotriphosphazene (Compound 3). The antibacterial activity Compound 3 was evaluated against Gram-positive Staphylococcus aureus (S. aureus) Gram-negative Pseudomonas aeruginosa (P. aeruginosa), Klebsiella pneumoniae (K. pneumoniae) bacterial strains using minimum inhibitory concentration (MIC) percentage-killing method. exhibited a lower MIC 300 μg/mL S. than 500 for P. K. pneumoniae, indicating greater efficacy bacteria. Percentage-killing data confirmed significant bactericidal across concentrations ranging from 100 to μg/mL, comparable ampicillin. In contrast, its lower, suggesting more selective spectrum activity. These findings suggest that shows promise as potential agent with preferential bacteria, warranting further investigation into mechanism action therapeutic potential.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0