Simple simultaneous analysis of various cardiovascular drug mixtures with vincamine: comparative eco-friendly assessment DOI Creative Commons
Sara S. Mourad,

Magda A. Barary,

Amira F. El‐Yazbi

et al.

BMC Chemistry, Journal Year: 2024, Volume and Issue: 18(1)

Published: Oct. 10, 2024

The development of two eco-friendly analytical methods for the simultaneous determination eight cardiovascular drugs; hydrochlorothiazide (HCT), captopril (CPL), lisinopril (LSP), valsartan (VAL), atorvastatin (ATR), bisoprolol (BSL), amlodipine (AML) and carvedilol (CVL); alongside with nutraceutical vincamine (VIC) is essential sustainable pharmaceutical analysis. This study explores application Micellar Electro Kinetic Chromatography (MEKC) High-Performance Liquid (HPLC) this purpose. In MEKC method, separation was done using fused silica capillary (41.5 cm × 50 µm id) a back ground electrolyte consisting mM borate buffer (pH 9) containing sodium lauryl sulphate (SLS) 10% organic modifier (Acetonitrile). HPLC performed on ZORBAX Extend-C18 (4.6 250 mm, 5 µm) column, gradient mobile phase phosphate pH 3 methanol. Both attained good linearity (r ≥ 0.9996) low values LOD LOQ. were successfully applied in co-administered single, binary ternary dosage form studied drugs. Moreover, various combinations forms achieved rat plasma, confirming applicability these different matrices. use micellar solutions enhances efficiency while reducing need solvents, aligning green chemistry principles. optimized environmentally benign ensuring reduced toxicity waste production. methodologies evaluated through green, white, blue metrics to ensure comprehensive sustainability, considering ecological impact, safety, practical efficiency. These not only cost-effective time-saving but high efficiency, sensitivity, reproducibility making them ideal routine

Language: Английский

Green analytical chemistry metrics for evaluating the greenness of analytical procedures DOI Creative Commons

Lei Yin,

Luyao Yu,

Yingxia Guo

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 14(11), P. 101013 - 101013

Published: May 25, 2024

Green analytical chemistry (GAC) focuses on mitigating the adverse effects of activities human safety, health, and environment. In addition to 12 principles GAC, proper GAC tools should be developed employed assess greenness different assays. The 15 widely used metrics, i.e., national environmental methods index (NEMI), advanced NEMI, assessment green profile (AGP), chloroform-oriented toxicity estimation scale (ChlorTox Scale), Analytical Eco-Scale, Certificate Modified method score (AMGS), procedure (GAPI), ComplexGAPI, red-green-blue (RGB) additive color model, RGB algorithm, calculator (AGREE), AGREE preparation (AGREEprep), HEXAGON, blue applicability grade (BAGI), are selected as typical tools. This article comprehensively presents elucidates principles, characteristics, merits, demerits review is helpful for researchers use current metrics sustainability

Language: Английский

Citations

45
Exploring the Potential of Green Chemistry in Reversed-Phase Liquid Chromatography : A Review of Sustainable Solvents DOI
Oktawia Kalisz, Marek Tobiszewski, Alicja Nowaczyk

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 181, P. 118007 - 118007

Published: Oct. 11, 2024

Language: Английский

Citations

8
Highly selective and sensitive detection of atorvastatin from using a MIP-based electrochemical sensor DOI Creative Commons
E. Pìşkìn,

Fatih Ahmet Korkut,

Ahmet Çetinkaya

et al.

Journal of Pharmaceutical and Biomedical Analysis Open, Journal Year: 2025, Volume and Issue: unknown, P. 100061 - 100061

Published: Feb. 1, 2025

Language: Английский

Citations

0
Green Analytical Chemistry—Recent Innovations DOI Creative Commons
Anil Kumar Meher,

Akli Zarouri

Analytica—A Journal of Analytical Chemistry and Chemical Analysis, Journal Year: 2025, Volume and Issue: 6(1), P. 10 - 10

Published: March 11, 2025

Green analytical chemistry represents a transformative approach to science, emphasizing sustainability and environmental stewardship while maintaining high standards of accuracy precision. This review highlights recent innovations in green chemistry, including the use solvents, such as water, supercritical carbon dioxide, ionic liquids, bio-based alternatives, well energy-efficient techniques like microwave-assisted, ultrasound-assisted, photo-induced processes. Advances instrumentation, miniaturized portable devices, integration automation chemometric tools, have further enhanced efficiency reduced footprint workflows. Despite these advancements, challenges remain, need balance performance with eco-friendliness lack global measure promote sustainable practices consistently. However, future looks promising, emerging technologies artificial intelligence digital tools offering new ways optimize workflows, minimize waste, streamline By focusing on areas, is transforming methodologies into that not only achieve but also align goals. underscores how more than just scientific discipline, pathway for reducing ecological impact processes driving innovation science industry. With continued commitment research, collaboration, adoption cutting-edge technologies, has potential shape greener its diverse applications.

Language: Английский

Citations

0
A novel electrochemical sensor based on reduced graphene oxide decorated with gold nanoparticles for voltammetric sensing of amlodipine in human urine DOI
Hoda M. Marzouk,

Sara El-Hanboushy,

Amr M. Mahmoud

et al.

Journal of Applied Electrochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Language: Английский

Citations

2
Green RP-HPLC method for impurity profile of amlodipine in tablets DOI Creative Commons
Olga Gigopulu, Hrisanta Godzo,

Biljana Atanasovska

et al.

Arhiv za farmaciju, Journal Year: 2024, Volume and Issue: 74(3), P. 216 - 234

Published: Jan. 1, 2024

Increased awareness of nature preservation has encouraged the introduction green analytical chemistry (GAC) practice concepts concerning several important aspects, including sustainable development, environmental impact, and minimum waste. The aim this research was to contribute implementation approach for pharmaceutical industry while retaining crucial aspects strict requirements quality control medicines. Therefore, an ethanolbased, robust high-performance liquid chromatography (HPLC) method determination related substances amlodipine (AML) in film-coated tablets developed optimized using Design Experiments (DoE). chromatographic separation performed on RP-select B column (250 x 4.0 mm, 5 mm), a mixture 0.04 M sodium dihydrogen phosphate monohydrate (pH 4.0) ethanol (60:40 % v/v) as mobile phase. conditions provided two specified impurities (impurity D impurity F). selectivity confirmed forced degradation studies. Analytical Eco-scale AGREE metrics that conforms GAC principles. validated successfully applied three samples from market, demonstrating applicability routine analysis.

Language: Английский

Citations

1
A Dual-Mode Spectrophotometric and Fluorescent Probe Based on Lignin-Derived Carbon Dots for the Detection of Atorvastatin Calcium in a Bulk Powder and a Commercial Product DOI
Fatemah Aldakhil, Nawal A. Alarfaj, Salma A. Al-Tamimi

et al.

Journal of Fluorescence, Journal Year: 2024, Volume and Issue: unknown

Published: May 30, 2024

Language: Английский

Citations

1
Greener method proposal for the determination of phenolic compounds and coumarins in aged sugarcane spirits using green bio-based solvents in HPLC-DAD-FLD system DOI Creative Commons

Daniel Andrade Rabelo Lima,

Eliete Costa Alves,

Jeancarlo Pereira dos Anjos

et al.

Green Analytical Chemistry, Journal Year: 2024, Volume and Issue: 10, P. 100138 - 100138

Published: Aug. 23, 2024

Language: Английский

Citations

1
One‐Pot Synthesis of Sustainable Fluorescent Nanomaterials via Microwave Irradiation as a Probe for the Determination of Metformin in Pure and Pharmaceutical Dosage Forms: Greenness and Whiteness Metrics DOI
Maha M. Abou El‐Alamin, D. Mohamed,

Amir Shaaban Farag

et al.

Luminescence, Journal Year: 2024, Volume and Issue: 39(10)

Published: Oct. 1, 2024

A rapid, green and sensitive technique for the determination of metformin was developed based on direct fluorescence enhancement carbon dots (CDs) induced by cited drug. The water-soluble CDs were prepared via a one-pot synthesis from avocado peels using domestic microwave. exhibited strong at 405 nm after excitation 320 with quantum yield 51%. enhanced linearly increasing concentration within range 0.5-25 μg/mL limit detection 0.087 quantification 0.263 μg/mL. designed probe proved to be selective toward in presence other drugs such as vildagliptin alogliptin also excipients pharmaceutical dosage form. suggested reported methods compared help whiteness greenness tools, specifically white analytical chemistry metric assessing hazardous solvents reagents used.

Language: Английский

Citations

1
Simple simultaneous analysis of various cardiovascular drug mixtures with vincamine: comparative eco-friendly assessment DOI Creative Commons
Sara S. Mourad,

Magda A. Barary,

Amira F. El‐Yazbi

et al.

BMC Chemistry, Journal Year: 2024, Volume and Issue: 18(1)

Published: Oct. 10, 2024

The development of two eco-friendly analytical methods for the simultaneous determination eight cardiovascular drugs; hydrochlorothiazide (HCT), captopril (CPL), lisinopril (LSP), valsartan (VAL), atorvastatin (ATR), bisoprolol (BSL), amlodipine (AML) and carvedilol (CVL); alongside with nutraceutical vincamine (VIC) is essential sustainable pharmaceutical analysis. This study explores application Micellar Electro Kinetic Chromatography (MEKC) High-Performance Liquid (HPLC) this purpose. In MEKC method, separation was done using fused silica capillary (41.5 cm × 50 µm id) a back ground electrolyte consisting mM borate buffer (pH 9) containing sodium lauryl sulphate (SLS) 10% organic modifier (Acetonitrile). HPLC performed on ZORBAX Extend-C18 (4.6 250 mm, 5 µm) column, gradient mobile phase phosphate pH 3 methanol. Both attained good linearity (r ≥ 0.9996) low values LOD LOQ. were successfully applied in co-administered single, binary ternary dosage form studied drugs. Moreover, various combinations forms achieved rat plasma, confirming applicability these different matrices. use micellar solutions enhances efficiency while reducing need solvents, aligning green chemistry principles. optimized environmentally benign ensuring reduced toxicity waste production. methodologies evaluated through green, white, blue metrics to ensure comprehensive sustainability, considering ecological impact, safety, practical efficiency. These not only cost-effective time-saving but high efficiency, sensitivity, reproducibility making them ideal routine

Language: Английский

Citations

0