Green Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
10, P. 100126 - 100126
Published: June 27, 2024
Evaluating
analytical
methods
with
innovative
metrics
is
essential
to
ensure
the
effectiveness
of
procedures.
Various
approaches
have
been
proposed
assess
performance
an
method
and
its
environmental
consequences,
as
sustainable
environment
green
chemistry
ideology
are
high
importance
nowadays.
Considering
greenness
evaluation
developed
procedures,
Green
Analytical
Procedure
Index
(GAPI),
one
these
metrics,
utilizes
five
distinct
colored
pentagons
evaluate
footprint
process
at
different
stages.
An
additional
tool
named
Complementary
(ComplexGAPI)
was
introduced
expand
on
GAPI
by
adding
fields
pertaining
processes
performed
prior
procedure
itself.
Nevertheless,
existing
ComplexGAPI
lacks
a
comprehensive
scoring
system
for
individual
methods,
which
would
allow
even
easier
comparison
procedures
using
this
tool.
In
response
queries
from
users,
study
introduces
refined
ComplexMoGAPI,
merging
visual
appeal
precise
total
scores.
The
accompanying
software
streamlines
application,
facilitating
quicker
simpler
evaluations.
This
available
open
source
bit.ly/ComplexMoGAPI.
We
believe
that,
following
success,
ComplexMoGAPI
will
also
gain
attention
eventually
trust
acceptance
chemical
community.
Green Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
9, P. 100112 - 100112
Published: April 21, 2024
The
greenness
assessment
of
analytical
methods
is
an
important
aspect
green
chemistry,
which
focuses
on
making
procedures
eco-friendly
and
safer.
This
study
conducts
a
thorough
comparative
analysis
chromatographic
utilized
in
the
Cilnidipine
(CLN),
commonly
employed
antihypertensive
medication.
research
aims
to
not
only
evaluate
performance
different
techniques
but
also
assess
their
environmental
impact,
with
focus
promoting
sustainable
practices
pharmaceutical
analysis.
profiles
twelve
for
CLN
its
derivatives
were
evaluated
utilizing
multiple
metrics
including
Green
Analytical
Procedure
Index
(GAPI),
GREEness
(AGREE),
eco-scale
(ESA),
Chloroform-oriented
Toxicity
Estimation
(ChlorTox
scale),
Blue
Applicability
Grade
(BAGI),
Red-Green-Blue
12
(RBG
12).
By
quantifying
implications,
highlight
importance
adopting
greener
encompasses
considerations
such
as
solvent
used,
energy
consumed,
waste
generated
by
method.
outcomes
this
contribute
valuable
insights
into
selection
environmentally
friendly
CLN,
balance
between
efficiency
ecological
responsibility
field.
Journal of AOAC International,
Journal Year:
2024,
Volume and Issue:
107(6), P. 891 - 902
Published: July 17, 2024
Abstract
Background
Intestinal
coccidiosis
is
a
debilitating
disease
in
poultry
and
livestock,
leading
to
economic
impact
worldwide.
Coccidiosis
prevented
treated
broilers
by
the
inclusion
of
anticoccidials
feed.
Toltrazuril
administered
potable
water
treat
coccidiosis.
Objective
Three
robust
analytical
methods
for
quantitation
toltrazuril
pure
pharmaceutical
formulations
are
developed.
Furthermore,
ecological
metrics,
either
penalization-
or
color-code-based
techniques,
applied
appraisal
assays.
Methods
First,
second-derivative
(Δλ;
5
nm)
spectrophotometric
method
used.
measured
from
peak
at
244–260
nm
within
linearity
range
5–25
μg/mL.
The
second
an
HPTLC
analysis
performed
on
aluminum
sheet
silica
gel
using
ethyl
acetate–methanol–ammonium
chloride
buffer–water
(8:1:0.5:0.5,
volume
respectively)
as
elution
phase.
Toltrazuril,
retardation
factor
0.66
±
0.01,
linearly
determined
1–9
μg/spot
243
nm.
third
reversed-phase
HPLC
with
diode
array
detection,
Agilent
C18
column
(5
μm,
4.6
×
150
mm)
isocratic
mode
1
mL/min
flow
rate
mobile
phase
acetonitrile
ratio
80:20
(v/v).
elutes
retention
time
2.58
0.1
min
0.25–25
Results
Calculated
2D-values
areas
highly
correlated
their
corresponding
drug
concentrations
coefficients:
r
>
0.999.
All
were
International
Council
Harmonization
(ICH)
validated
dosage
form
satisfactory
%
recoveries
(97–103%).
Statistical
comparisons
versus
reported
one
t-test
F-test
disclose
insignificant
variation.
In
examining
greenness
whiteness
norms,
proposed
evaluated
ranked
alongside
four
different
methods.
Conclusions
green,
accurate,
can
be
routine
QC
determination
formulations.
Highlights
substantially
affects
chicken
intestinal
tract
reduced
growth.
used
treatment
prevention
robust,
precise
developed
ecologically
assessed
compared
published
ones.
Green Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
9, P. 100114 - 100114
Published: April 20, 2024
The
literature
review
uncovers
the
quantitative
analysis
of
atropine
sulfate
using
either
direct
determination
methods
or
chemical
derivatization
techniques.
However,
in
order
to
innovate
upon
traditional
analytical
approaches,
an
alternative
method
for
estimating
was
developed
natural
pH
indicator
turmeric.
An
economical
and
accurate
technique
utilizing
turmeric
powder
devised
quantification
sulphate
both
bulk
tablet
dosage
forms.
maximum
absorption
identified
at
600
nm,
with
a
linear
range
spanning
0.5
–
2.5
µg/ml.
correlation
coefficient
(r)
calculated
be
0.9997±0.0006,
demonstrating
exceptional
level
linearity.
Rigorous
validation
proposed
affirmed
its
simplicity,
precision,
accuracy,
rapidity
determining
pure
form
Additionally,
approach
underwent
assessment
through
Analytical
GREEnness
Metric
(AGREE),
Green
Procedure
Index
(GAPI),
Eco-scale
Assessment
(AES).
AGREE
AES
scores
were
observed
0.78
96,
respectively,
signaling
highly
favorable
eco-friendly
outcomes.
