Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(45), P. 9082 - 9085
Published: Jan. 1, 2023
2-Allyloxybenzaldehydes
undergo
[2
+
1]
cycloadditions
under
365
nm
LED
irradiation
to
form
the
corresponding
chroman-fused
cyclopropanols.
The
reaction
proceeds
easily
without
any
catalysts
or
additives
in
dimethyl
sulfoxide.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(28), P. 10963 - 10968
Published: Jan. 1, 2024
The
catalytic
asymmetric
propargylation
of
cyclopropanols
has
been
developed
using
a
new
PyBox
ligand,
yielding
cyclopentanones
with
an
all-carbon
quaternary
stereogenic
center
and
adjacent
gem
-dimethyl
carbon
center.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(44), P. 9553 - 9557
Published: Oct. 28, 2024
Selective
C–C
bond
cleavage
and
transformation
of
organic
small
molecules
to
create
products
increased
value
are
one
the
central
goals
in
chemistry.
In
this
study,
we
have
developed
a
novel
TEMPO-mediated
ring-opening
α,β-difunctionalization
cyclopropyl
alcohols
with
azides
prepare
structurally
important
4-keto-1,2,3-triazoles
under
metal-
additive-free
conditions.
This
protocol
not
only
provides
straightforward
efficient
method
for
synthesis
4-keto-functionalized
1,2,3-triazoles
pot
but
also
accomplishes
goal
constructing
α,β-double
C–N
bonds
via
ring
opening
first
time.
Additionally,
application
skeletons
drugs
natural
Kv1.5
channel
blocker
4u
further
demonstrate
synthetic
potential
practicability
strategy.
