Defunctionalization Enabled by Intramolecular Radical Aromatic Ipso Substitution DOI

Qijing Zhang,

Tinglan Liu,

Lili Wu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(36), P. 7744 - 7750

Published: Sept. 5, 2024

A chemoselective and regioselective copper-promoted defunctionalization procedure has been developed, enabling the rapid construction of various

Language: Английский

Construction of Functionalized Oxindoles by Quinone-Carbonate Synergistically Triggered Intermolecular Radical Coupling DOI
Yun Qiu,

Zecheng Wu,

Xingyun Ou

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(17), P. 12753 - 12761

Published: Aug. 27, 2024

We disclose a rapid and nontoxic procedure to construct various oxindoles. This method harnesses the power of catalytic amount quinone in synergy with Cs2CO3, showcasing remarkable compatibility wide range functional groups. Mechanistic investigations reveal that it operates via radical pathway, likely initiated by single-electron transfer from quinone-Cs2CO3 complexes. pivotal electron event leads generation crucial alkyl intermediate, contributing overall success efficacy transformation.

Language: Английский

Citations

1
Defunctionalization Enabled by Intramolecular Radical Aromatic Ipso Substitution DOI

Qijing Zhang,

Tinglan Liu,

Lili Wu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(36), P. 7744 - 7750

Published: Sept. 5, 2024

A chemoselective and regioselective copper-promoted defunctionalization procedure has been developed, enabling the rapid construction of various

Language: Английский

Citations

1