Construction of Functionalized Oxindoles by Quinone-Carbonate Synergistically Triggered Intermolecular Radical Coupling
Yun Qiu,
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Zecheng Wu,
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Xingyun Ou
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et al.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(17), P. 12753 - 12761
Published: Aug. 27, 2024
We
disclose
a
rapid
and
nontoxic
procedure
to
construct
various
oxindoles.
This
method
harnesses
the
power
of
catalytic
amount
quinone
in
synergy
with
Cs2CO3,
showcasing
remarkable
compatibility
wide
range
functional
groups.
Mechanistic
investigations
reveal
that
it
operates
via
radical
pathway,
likely
initiated
by
single-electron
transfer
from
quinone-Cs2CO3
complexes.
pivotal
electron
event
leads
generation
crucial
alkyl
intermediate,
contributing
overall
success
efficacy
transformation.
Language: Английский
Defunctionalization Enabled by Intramolecular Radical Aromatic Ipso Substitution
Qijing Zhang,
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Tinglan Liu,
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Lili Wu
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et al.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(36), P. 7744 - 7750
Published: Sept. 5, 2024
A
chemoselective
and
regioselective
copper-promoted
defunctionalization
procedure
has
been
developed,
enabling
the
rapid
construction
of
various
Language: Английский