MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136181 - 136181

Published: Oct. 15, 2024

Language: Английский

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Cyanobacteria and microcystins contamination in drinking water sources: a review of occurrence, exposure, and mitigation measures

Toxicology and Environmental Health Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 10, 2024

Language: Английский

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Effects of Harmful Algal Blooms on Amphibians and Reptiles are Under‐Reported and Under‐Represented

Environmental Toxicology and Chemistry, Journal Year: 2024, Volume and Issue: 43(9), P. 1936 - 1949

Published: July 5, 2024

Harmful algal blooms (HABs) are a persistent and increasing problem globally, yet we still have limited knowledge about how they affect wildlife. Although semi-aquatic aquatic amphibians reptiles experienced large declines occupy environments where HABs increasingly problematic, their vulnerability to remains unclear. To inform monitoring, management, future research, conducted literature review, synthesized the studies, report on mortality events describing effects of cyanotoxins from freshwater herpetofauna. Our review identified 37 unique studies 71 endpoints (no-observed-effect lowest-observed-effect concentrations) involving 11 amphibian 3 reptile species worldwide. Responses varied widely among species, exposure concentrations used in experiments. Concentrations causing lethal sublethal laboratory experiments were generally 1 100 µg/L, which contains mean value reported HAB but is 70 times less than maximum cyanotoxin environment. However, one was tolerant 10,000 demonstrating potentially immense differences sensitivities. Most focused microcystin-LR (MC-LR), can increase systemic inflammation harm digestive system, reproductive organs, liver, kidneys, development. The few other illustrated that resembled those MC-LR at similar concentrations, more research needed describe mixtures commonly occur All experimental larval adult amphibians; there no such reptiles. Experimental work with clarify thresholds tolerance. Only nine reported, mostly for Given likely decay faster reptiles, tissues resist decomposition, mass been under-reported. We propose efforts should be seven major areas, enhance our understanding monitoring herpetofauna fill important roles terrestrial environments. Environ Toxicol Chem 2024;43:1936-1949. Published 2024. This article U.S. Government public domain USA. Environmental Toxicology Chemistry published by Wiley Periodicals LLC behalf SETAC.

Language: Английский

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Seasonal dynamics of toxigenic Microcystis in a large, shallow Lake Peipsi (Estonia) using microcystin mcyE gene abundance

Environmental Monitoring and Assessment, Journal Year: 2024, Volume and Issue: 196(8)

Published: July 18, 2024

Language: Английский

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Occurrence of microcystins in water, sediment, and aquatic animals in Dau Tieng Reservoir, Vietnam

Journal of Oceanology and Limnology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Language: Английский

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The Role of Heterocysts in Cyanotoxin Production during Nitrogen Limitation

Toxins, Journal Year: 2023, Volume and Issue: 15(10), P. 611 - 611

Published: Oct. 13, 2023

Cyanobacteria harmful algal blooms (cyanoHABs) can have impacts on human health, aquatic ecosystems, and the economy. Nutrient management is an important mitigation even remediation strategy. In this work, paralytic shellfish toxin (PST)-producing Aphanizomenon (Aphan.) flos-aquae (Linnaeus) Ralfs ex Bornet & Flahault (now identified as Aphan. sp.) single filament isolate NH-5 was grown in P-depleted media, N-depleted complete BG-11 media. Growth heterocyst vegetative cells were monitored using dry weight cell counts. Ultrasonication used to separate heterocysts from cells. HPLC-FLD with post-column derivatization determine saxitoxin (STX) neosaxitoxin (NEOSTX) concentration per cell. sp. biomass lower media than control, though higher counts detected The significantly compared for However, no significant differences found among all preparations regard STX-to-NEOSTX ratio. We conclude that N limitation induced numbers fixation activity a factor behind increase STX NEOSTX production of NH-5.

Language: Английский

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An assessment of a biosensor system for the quantification of microcystins in freshwater cyanobacterial blooms

Analytical Biochemistry, Journal Year: 2023, Volume and Issue: 687, P. 115429 - 115429

Published: Dec. 17, 2023

Language: Английский

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Microcystin Concentrations, Partitioning, and Structural Composition during Active Growth and Decline: A Laboratory Study

Toxins, Journal Year: 2023, Volume and Issue: 15(12), P. 684 - 684

Published: Dec. 6, 2023

Microcystin can be present in variable concentrations, phases (dissolved and particulate), structural forms (congeners), all which impact the toxicity persistence of algal metabolite. Conducting incubation experiments with six bloom assemblages collected from Chowan River, North Carolina, we assessed microcystin dynamics during active growth biomass degradation. Upon collection, average particulate dissolved ranged between 0.2 993 µg L−1 0.5 3.6 L−1, respectively. The presence congeners MC-LA, -LR, -RR, -YR was confirmed MC-RR MC-LR being most prevalent. Congener composition shifted over time varied phases. Particulate exponentially declined five incubations an half-life 10.2 ± 3.7 days, while remained detectable until end trials (up to 100 days). Our findings suggest that concerns about food-web transfer via intracellular toxins seem warranted within first few weeks peak, linger for several months aftermath event. Also, it indicated there were differences congener profiles linked sampling method. We believe this study inform monitoring strategies aid microcystin-exposure risk assessments cyanobacterial blooms.

Language: Английский

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Environmental Drivers of Phytoplankton Community Dynamics in an Agriculturally-Influenced Tributary in the Lower Great Lakes

Published: Jan. 1, 2024

Phytoplankton community composition in tributaries differs from that their receiving waters, due to light limitation suspended particles among other factors such as nutrient availability and temperature. This study was designed manipulate levels early, mid, late summer determine the combined effects of attenuation with naturally varying on phytoplankton an agriculturally-influenced tributary lower Great Lakes. In all trials, situ microcosm experiments show abundance increased under three treatments (60%, 75%, 85% attenuation) relative time-zero, but higher reduced total controls. Highest diversity terms richness evenness occurred September, across trials lowest highest treatments. followed a normal seasonal shift diatoms dominating June, by cyanobacteria mid summer. general, corresponded dominance cyanobacteria. These findings support hypothesis vary promotes buoyant taxa more tolerant low levels.

Language: Английский

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Microcystins and Nodularin in Agricultural Products: Toxicity, Analytical Methods, Contamination Pathway, Occurrence, and Safety Management

Journal of Food Hygiene and Safety, Journal Year: 2024, Volume and Issue: 39(3), P. 191 - 208

Published: June 30, 2024

Language: Английский

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