Cellular and Tissue-Level Responses of Mussels (Mytilus edulis) to Aged Polyethylene Terephthalate (PET) Micro- and Nanoplastic Particles DOI Creative Commons

Jenevieve Hara,

Gethrie B Oraño,

Maaike Vercauteren

et al.

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 107369 - 107369

Published: April 1, 2025

Micro- and nanoplastic particles (MNPs) are pollutants of global concern due to their persistence, ubiquity, associated risks. Laboratory studies, however, have predominantly focused on pristine MNPs, which do not adequately reflect the characteristics environmental plastic debris. To address this gap, study investigated cellular tissue-level responses mussels (Mytilus edulis) aged polyethylene terephthalate (PET) MNPs (diameter 600 nm 3.1 µm) at three environmentally relevant concentrations: 10, 103, 105 particles/L. The particles' physicochemical stability in exposure media were analyzed using a combination advanced analytical techniques. biological across multiple effect endpoints during both (days 1, 3, 7, 14) subsequent recovery periods (3 10 days post-exposure), via flow cytometry histopathology. results revealed sensitivity hemocyte subpopulations, including granulocytes hyalinocytes, PET MNPs. Concentration- time-dependent changes lysosomal stability, oxidative activity, mortality observed, demonstrating immediate perturbations potential alleviate particle-induced effects. Histopathological analysis key tissues exhibited significant alterations, particularly gill, suggesting impairment essential physiological functions. No mussel or growth metrics observed under tested experimental conditions. These findings underscore systemic impacts MNP highlight importance adopting integrative, realistic approaches assess consequences future research.

Language: Английский

Cellular and Tissue-Level Responses of Mussels (Mytilus edulis) to Aged Polyethylene Terephthalate (PET) Micro- and Nanoplastic Particles DOI Creative Commons

Jenevieve Hara,

Gethrie B Oraño,

Maaike Vercauteren

et al.

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 107369 - 107369

Published: April 1, 2025

Micro- and nanoplastic particles (MNPs) are pollutants of global concern due to their persistence, ubiquity, associated risks. Laboratory studies, however, have predominantly focused on pristine MNPs, which do not adequately reflect the characteristics environmental plastic debris. To address this gap, study investigated cellular tissue-level responses mussels (Mytilus edulis) aged polyethylene terephthalate (PET) MNPs (diameter 600 nm 3.1 µm) at three environmentally relevant concentrations: 10, 103, 105 particles/L. The particles' physicochemical stability in exposure media were analyzed using a combination advanced analytical techniques. biological across multiple effect endpoints during both (days 1, 3, 7, 14) subsequent recovery periods (3 10 days post-exposure), via flow cytometry histopathology. results revealed sensitivity hemocyte subpopulations, including granulocytes hyalinocytes, PET MNPs. Concentration- time-dependent changes lysosomal stability, oxidative activity, mortality observed, demonstrating immediate perturbations potential alleviate particle-induced effects. Histopathological analysis key tissues exhibited significant alterations, particularly gill, suggesting impairment essential physiological functions. No mussel or growth metrics observed under tested experimental conditions. These findings underscore systemic impacts MNP highlight importance adopting integrative, realistic approaches assess consequences future research.

Language: Английский

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