Comparative analysis of transcriptomic points-of-departure (tPODs) and apical responses in embryo-larval fathead minnows exposed to fluoxetine

Environmental Pollution, Journal Year: 2021, Volume and Issue: 295, P. 118667 - 118667

Published: Dec. 9, 2021

Language: Английский

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Pharmaceutical Pollution Alters the Structure of Freshwater Communities and Hinders Their Recovery from a Fish Predator

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(31), P. 13904 - 13917

Published: July 25, 2024

Freshwater ecosystems are under threat from rising pharmaceutical pollution. While such pollutants known to elicit biological effects on organisms, we have limited knowledge how these might cascade through food-webs, disrupt ecological processes, and shape freshwater communities. In this study, used a mesocosm experiment explore the community impacts of top-order predator, eastern mosquitofish (

Language: Английский

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Context is Key: Social Environment Mediates the Impacts of a Psychoactive Pollutant on Shoaling Behavior in Fish

Environmental Science & Technology, Journal Year: 2021, Volume and Issue: unknown

Published: Sept. 20, 2021

Behavior-modifying drugs, such as antidepressants, are increasingly being detected in waterways and aquatic wildlife around the globe. Typically, behavioral effects of these contaminants assessed using animals tested social isolation. However, for group-living species, seen isolation may not reflect those occurring realistic settings. Furthermore, interactions between chemical pollution other stressors, predation risk, seldom considered. This is true even though wild rarely, if ever, confronted by a single stressor. Here, 2 year multigenerational experiment, we antidepressant fluoxetine (measured concentrations [±SD]: 42.27 ± 36.14 359.06 262.65 ng/L) on shoaling behavior guppies (Poecilia reticulata) across different contexts under varying levels perceived risk. Shoaling propensity shoal choice (choice groups with densities) were Y-maze presence predatory or nonpredatory heterospecific, individually male-female pairs. When individually, no effect was behavior. paired trials, high-fluoxetine-exposed fish exhibited significantly greater propensity. Hence, mediated context, highlighting importance this fundamental but rarely considered factor when evaluating impacts environmental pollution.

Language: Английский

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Combined effects of climate change and BDE-209 dietary exposure on the behavioural response of the white seabream, Diplodus sargus

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 881, P. 163400 - 163400

Published: April 11, 2023

Language: Английский

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Bigger and bolder: Widespread agricultural pollutant 17β-trenbolone increases growth and alters behaviour in tadpoles (Litoria ewingii)

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 260, P. 106577 - 106577

Published: May 15, 2023

Language: Английский

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Are early and young life stages of fish affected by paroxetine? A case study with Danio rerio

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 900, P. 165706 - 165706

Published: July 25, 2023

Paroxetine (PAR) is a selective serotonin reuptake inhibitor (SSRI) antidepressant increasingly detected in surface waters worldwide. Its environmental presence raises concerns about the potential detrimental effects on non-target organisms. Thus, this study aimed to increase knowledge PAR's impacts, assessing of commercial formulation (PAR-c) and active ingredient (PAR-a) fish. Therefore, short-term exposure PAR-c PAR-a were assessed zebrafish (Danio rerio) embryos/larvae determine most toxic [through median lethal (LC50) effective concentrations (EC50)]. induced morphological abnormalities (scoliosis) dose-dependent manner from 96 hours post-fertilization onwards, suggesting involvement fully functional biotransformation system. As exhibited higher toxicity, it was selected be tested subsequent stage (juvenile stage), which more sensitive (lower LC50). significantly decreased fish swimming activity disrupted stress response. Overall, results highlight ability adversely affect performance, an effect that persisted even after ceases (21-day depuration), may impair individual fitness.

Language: Английский

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Unraveling the combined toxicity and removal mechanisms of fluoxetine and sertraline co-contaminants by the freshwater microalga Chlorella pyrenoidosa

Chemosphere, Journal Year: 2023, Volume and Issue: 343, P. 140217 - 140217

Published: Sept. 20, 2023

Language: Английский

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Personality Affects Zebrafish Response to Sertraline

Environmental Toxicology and Chemistry, Journal Year: 2023, Volume and Issue: 43(1), P. 132 - 146

Published: Oct. 20, 2023

Sertraline is widely prescribed to treat anxiety and depression. acts by blocking serotonin, norepinephrine, dopamine transporters systems has been detected in surface waters globally, where it may impact fish behavior. We classified zebrafish personality on three behavioral axes, boldness, anxiety, sociability, assigning as either high or low each category. The were exposed nominal concentrations of 0, 5, 50, 500, 5000 ng/L sertraline (measured concentrations: <10, 21.3, 370, 2200 ng/L, respectively) assess changes sociability after 7 28 days. also measured shoaling behavior response an alarm cue, determined the gut microbiome a subset fish. After days there was no overall effect but interaction between initial sex, with stronger females low-boldness personality. reduced all treatments compared control, again Fish that low-sociability responded more strongly sertraline. days, concentration (2200 measured) showed higher than controls, pattern retained. similar patterns observed, variation. There only weak association Overall, study highlights importance considering behavior, which can affect pollutants. Our results be applicable human studies provide mechanism explain why different individuals respond differently drug. Environ Toxicol Chem 2024;43:132-146. © 2023 SETAC.

Language: Английский

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Effects of norethindrone on the growth, behavior, and thyroid endocrine system of adult female western mosquitofish (Gambusia affinis)

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 267, P. 115630 - 115630

Published: Oct. 25, 2023

Progestins are mainly used in pharmacotherapy and animal husbandry have received increasing attention as they widely detected various aquatic ecosystems. In this study, adult female western mosquitofish (Gambusia affinis) were exposed to different concentrations of norethindrone (NET) (solvent control, 5.0 (L), 50.0 (M), 500.0 (H) ng/L) for 42 days. Behaviors, morphological parameters, histology the thyroid, thyroid hormone levels (TSH, T3, T4), transcriptional nine genes hypothalamic-pituitary-thyroid (HPT) axis examined. The results showed that NET decreased sociality but increased anxiety G. affinis. Sociality makes fish tend cluster, may cause affinis reduce exploration new environments. Female hyperplasia, hypertrophy, glial depletion their follicular epithelial cells after treatment. plasma TSH T4 significantly reduced, T3 from H group. addition, transcripts (tshb, tshr, tg, dio1, dio2, thrb) brains M treatments stimulated, while those trh pax2a suppressed. Our suggest impact key social behaviors interfere with entire endocrine system, probably via affecting expression upstream regulators HPT axis.

Language: Английский

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The endocrine disruptor 17β-trenbolone alters the relationship between pre- and post-copulatory sexual traits in male mosquitofish (Gambusia holbrooki)

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 790, P. 148028 - 148028

Published: May 26, 2021

It is now well-established that reproduction in wildlife can be disrupted by anthropogenic environmental changes, such as chemical pollution. However, very little known about how these pollutants might affect the interplay between pre- and post-copulatory mechanisms of sexual selection. Here, we investigated impacts 21-day exposure male eastern mosquitofish (Gambusia holbrooki) to a field-realistic level (average measured concentration: 11 ng/L) endocrine-disrupting 17β-trenbolone (17β-TB) on reproductive traits. We examined behaviour testing time spent near female behind partition, well number copulation attempts made, chasing free-swimming context. Sperm traits were also assayed for all males. found fish 17β-TB altered relationship key Furthermore, 17β-TB-exposed males had, average, higher percentage motile sperm, performed fewer than unexposed there was no overall effect either associating with or females. Taken together, our findings demonstrate potential both traits, selection contaminated wildlife.

Language: Английский

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