Disparities in Heart Transplantation Allocation and Outcomes by Blood Type in Korea (2010–2022)

Korean Circulation Journal, Journal Year: 2025, Volume and Issue: 55

Published: Jan. 1, 2025

This study aimed to elucidate the influence of recipient blood type on heart transplant allocation dynamics in Korea, focusing donor matching, wait times, and post-transplant survival from 2010 2022. In this retrospective cohort study, we examined 1,745 recipients classified by types: A (n=631), B (n=488), AB (n=256), O (n=370). Parameters studied encompassed ages, compatibility, organ type, emergency status, waiting periods, rates up one year post-transplant. investigation revealed significant disparities outcomes for waitlist patients, differentiated type. encountered notably extended median times 110 days (an average 300±514 days), which is substantially longer compared (65 (58 (29 days). Furthermore, mortality rate while was markedly high at 78.1%, contrast 75.2% A, 72.3% B, 48.5% AB. who, despite constituting a proportion pool (34.1%), received transplants disproportionately lower rates. Type Korea face challenges, including higher during period frequent necessity left ventricular assist device interventions. Urgent policy reforms are needed address these improve equitable patients.

Language: Английский

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Can we safely expand the donation after circulatory death donor heart pool by extending the donor age limit?

Journal of Thoracic and Cardiovascular Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Language: Английский

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Effects of ex vivo machine perfusion on preservation time and donor age in donation after brain death heart transplantation

The Journal of Heart and Lung Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

With encouraging early experience, ex vivo machine perfusion (MP) systems are increasingly employed in heart transplantation. In this study, utilizing a national registry database, 2 separate analyses were performed to evaluate the effects of MP on graft preservation time (total n = 22,794; 308 with MP) and donor age 22,581; 95 donation after brain death (DBD) The cohort was stratified based total (<4 ≥4 hours) (<45 ≥45 years). During study period, use isolated DBD transplantation significantly increased. Utilization associated improved 90-day post-transplant survival among recipients times hours or years, compared cases where not utilized. These findings positively highlight potential utility involving longer older donors.

Language: Английский

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Abnormal invasive hemodynamics in heart transplant recipients: A single-center, retrospective study

World Journal of Transplantation, Journal Year: 2025, Volume and Issue: 15(3)

Published: April 18, 2025

BACKGROUND Few studies have quantified invasive hemodynamic parameters in post heart transplant recipients. AIM To report the incidence of abnormal hemodynamics recipients at 1-year and 3-year post-transplant determine if there was any correlation with recipient donor characteristics. METHODS Data from 279 consecutive 2007 through 2020 were analyzed. Clinical variables regarding both donors as well obtained via right catheterization during annual testing recorded. Simple multiple linear regression tests used to how influenced 3-year. RESULTS available for 260 patients 224 respectively. At 1-year, common 24% having atrial pressure (RAP) > 10 mmHg, 52% mean pulmonary artery 20 12% capillary wedge (PCWP) 18 mmHg. Similar abnormalities noted post-transplant. Recipient body mass index (BMI) demonstrated strongest all 3 by multivariate analysis (P < 0.001 both). Both age predicted difference between significantly linked RAP PCWP but did not predict CONCLUSION Abnormal are associated high BMI.

Language: Английский

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The Role of Sodium-Glucose Cotransporter-2 Inhibitors in Adults With Transthyretin Cardiac Amyloidosis: A Single-Center Retrospective Cohort Study

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Background: Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy with limited treatment options. Barring mineralocorticoid receptor antagonists, most classes of guideline-directed medical therapy including renin-angiotensin-aldosterone inhibitors and beta blockers are avoided in CA due to intolerance the risk potentiating orthostatic hypotension. Few studies have explored safety utility sodium-glucose cotransporter-2 (SGLT2is) CA. These agents demonstrated benefit heart failure phenotypes, individuals may from them. We report a single-center experience demonstrating SGLT2is patients cardiac amyloidosis. Methods: conducted retrospective study January 2020 March 2023 who were treated empagliflozin at doses 10 mg or 25 daily dapagliflozin dose daily. Patients monitored clinically for development adverse effects urinary tract infections hypotension as well through laboratory monitoring acute kidney injury changes microalbuminuria. Results: Our cohort comprised 53 SGLT2i, 38 (72%) whom male, mean participant age 81±8 years left ventricular ejection fraction 50%. Urinary observed three participants (6%). Acute occurred two participants. No experienced There was trend toward improved functional status, reduced hospitalizations (decrease median 1 0.6 per patient-year, p=0.18), microalbuminuria (mean albumin:creatinine ratio 53.8 mg/g 29.2 mg/g, p=0.32), although these differences not statistically significant. Conclusions: Within our amyloidosis, SGLT2i appeared be well-tolerated clinical form improvements Notably, outcomes By tolerance, we hope stimulate prospective randomized that definitively explore enhancing outcomes.

Language: Английский

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Donor age and ischemic time in heart transplantation –implications for organ preservation

The Journal of Heart and Lung Transplantation, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Just a number? Donor age and (lack of) associated reasons for heart offer refusal

The Journal of Heart and Lung Transplantation, Journal Year: 2024, Volume and Issue: 43(11), P. 1833 - 1837

Published: July 31, 2024

Language: Английский

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Donor Selection for Heart Transplantation in 2024

JACC Heart Failure, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Effect of CMV Mismatch on Heart Transplant Outcomes Using a Surveillance and Preemptive Strategy

Clinical Transplantation, Journal Year: 2024, Volume and Issue: 38(9)

Published: Sept. 1, 2024

ABSTRACT Purpose The aim of the study was to determine outcomes after heart transplantation for cytomegalovirus (CMV) mismatched patients (D + /R − ) who underwent a surveillance and preemptive therapy protocol, compared nonmismatch patients. Methods A review patient records from January 2010 December 2020 with follow‐up October 2023 done. protocol consisted weekly CMV PCR starting 4 weeks transplant continuing up until seroconverts or 3 months posttransplant if does not seroconvert. Valganciclovir given 2 those seroconverted. Results Two hundred twenty‐one were included, 23% Overall survival different between groups ( p = NS). Causes death morbidities also significantly Sixty‐six percent mismatch seroconverted, there older donor age in seroconverted nonseroconverted (41 ± 11 vs. 29 12 years, < 0.005), indicating higher risk profile. multivariate Cox regression including showed that no increase mortality mismatches Conclusions There is significant increased morbidity using protocol. effect on seroconversion requires further validation.

Language: Английский

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Donor pulmonary hemodynamics does not impact recipient outcomes in adult heart transplantation.

International Journal of Cardiology, Journal Year: 2024, Volume and Issue: 420, P. 132747 - 132747

Published: Nov. 16, 2024

Language: Английский

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