The effect of warm ischemic intervals on primary graft dysfunction in normothermic regional perfusion for donation after circulatory death heart transplant DOI Creative Commons
Chen Chia Wang, Mark Petrovic, Arshad Ahmad

et al.

Journal of Thoracic and Cardiovascular Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

To clarify the association between warm ischemic time during donation after circulatory death (DCD) and severe primary graft dysfunction (PGD) heart transplant. DCD transplants using normothermic regional perfusion, excluding congenital etiology or multiorgan transplant, at a single institution from January 2020 to December 2024 were reviewed. Donation withdrawal (DWIT), functional time, defined by oxygen saturation <80% (FWIT O2), systolic blood pressure <80 mm Hg <50 Hg, asystolic examined. Propensity matching created balanced cohorts associate ischemia outcomes. Outcomes included incidence of PGD, lengths stay, mortality. The final study cohort had 135 patients, whom 10 (7.4%) PGD. When stratified donor recipient demographics similar. DWIT (median 25.0 minutes vs 35.5 minutes, P = .031) FWIT O2 22.0 33.0 .025) lower in those without Logistic regression identified as better predictor compared with DWIT. Receiver operating characteristic curve analysis threshold 23 (area under curve, 0.714). After matching, rates PGD significantly greater >23 group (8/59 [13.6%] 1/59 [1.7%], .032). However, similar stay In perfusion is associated increased was not other outcomes, including Rejection allografts on basis prolonged may lead unnecessary discard viable hearts.

Language: Английский

What We Know We Don’t Know: The Johari Window in DCD Heart Transplantation DOI
Scott Silvestry

The Journal of Heart and Lung Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
The effect of warm ischemic intervals on primary graft dysfunction in normothermic regional perfusion for donation after circulatory death heart transplant DOI Creative Commons
Chen Chia Wang, Mark Petrovic, Arshad Ahmad

et al.

Journal of Thoracic and Cardiovascular Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

To clarify the association between warm ischemic time during donation after circulatory death (DCD) and severe primary graft dysfunction (PGD) heart transplant. DCD transplants using normothermic regional perfusion, excluding congenital etiology or multiorgan transplant, at a single institution from January 2020 to December 2024 were reviewed. Donation withdrawal (DWIT), functional time, defined by oxygen saturation <80% (FWIT O2), systolic blood pressure <80 mm Hg <50 Hg, asystolic examined. Propensity matching created balanced cohorts associate ischemia outcomes. Outcomes included incidence of PGD, lengths stay, mortality. The final study cohort had 135 patients, whom 10 (7.4%) PGD. When stratified donor recipient demographics similar. DWIT (median 25.0 minutes vs 35.5 minutes, P = .031) FWIT O2 22.0 33.0 .025) lower in those without Logistic regression identified as better predictor compared with DWIT. Receiver operating characteristic curve analysis threshold 23 (area under curve, 0.714). After matching, rates PGD significantly greater >23 group (8/59 [13.6%] 1/59 [1.7%], .032). However, similar stay In perfusion is associated increased was not other outcomes, including Rejection allografts on basis prolonged may lead unnecessary discard viable hearts.

Language: Английский

Citations

0