Hearing Research, Journal Year: 2023, Volume and Issue: 430, P. 108708 - 108708
Published: Feb. 2, 2023
Language: Английский
Human & Experimental Toxicology, Journal Year: 2024, Volume and Issue: 43
Published: Jan. 1, 2024
Objective Environmental factors such as noise and music can significantly impact physiological responses, including inflammation. This study explored how environmental like affect lipopolysaccharide (LPS)-induced inflammation, with a focus on systemic organ-specific responses. Materials Methods 24 Wistar rats were divided into four groups ( n = 6 per group): Control group, LPS noise-exposed music-exposed group. All rats, except for the received 10 mg/kg intraperitoneally. The in group exposed to 95 dB noise, listened Mozart’s K. 448 (65–75 dB) 1 h daily over 7 days. An enzyme-linked immunosorbent assay was utilized detect levels of inflammatory cytokines, tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β), serum tissues (lung, liver, kidney). Western blot examined phosphorylation nuclear factor-κB (NF-κB) p65 organ tissues. Results Compared LPS-induced sepsis displayed significant increase TNF-α IL-1β serum, lung, kidney tissues, well remarkable elevation p-NF-κB protein expression Noise exposure further amplified these markers, while reduced them rats. Conclusion exacerbates inflammation by activating NF-κB pathway, leading up-regulation markers during sepsis. On contrary, inhibits signaling, indicating potential therapeutic effect reducing
Language: Английский
Citations
3
European Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 57(6), P. 981 - 1002
Published: Jan. 23, 2023
Varying degrees of pure-tone hearing loss in older adults are differentially associated with cortical volume (CV) and thickness (CT) within outside the auditory pathway. This study addressed question to what degree supra-threshold performance (i.e., temporal compression frequency selectivity) as well speech noise (SiN) recognition neurostructural correlates a sample 59 healthy mild moderate loss. Using surface-based morphometry on T1-weighted MRI images, CT, CV, surface area (CSA) several regions-of-interest were obtained. The results showed distinct patterns for different tasks terms involved regions morphometric parameters. While averages (PTAs) positively correlated CT right hemisphere superior sulcus gyrus cluster, perception additionally extended significantly CV left clusters including Heschl's sulcus, planum polare temporale. For SiN recognition, we found significant correlations an auditory-related cluster furthermore language-related areas prefrontal cortex. Taken together, our show that abilities differently morphology impairment. Still, common pattern is greater PTAs poorer all related thinning but not changes CSA. These support hypothesis mostly undergoes alterations context decline, while CSA remains stable.
Language: Английский
Citations
6
iScience, Journal Year: 2024, Volume and Issue: 27(5), P. 109691 - 109691
Published: April 9, 2024
Salicylate is commonly used to induce tinnitus in animals, but its underlying mechanism of action still debated. We therefore tested effects on the firing properties neurons mouse inferior colliculus (IC). induced a large decrease spontaneous activity and an increase ∼20 dB SPL minimum threshold single units. In response sinusoidally modulated noise (SAM noise) units showed both phase locking improved rate coding. Mice also became better at detecting amplitude modulations, simple model based IC population could reproduce this improvement. The responses dynamic random chords (DRCs) suggested that AM encoding was due linearization cochlear output, resulting larger contrasts during SAM noise. These salicylate are not consistent with presence tinnitus, should be taken into account when studying hyperacusis.
Language: Английский
Citations
2
Hearing Research, Journal Year: 2023, Volume and Issue: 430, P. 108708 - 108708
Published: Feb. 2, 2023
Language: Английский
Citations
2