Sex-specific age-related changes in excitatory and inhibitory intra-cortical circuits in mouse primary auditory cortex DOI Creative Commons
Zheng Xu, Binghan Xue, Joseph P. Y. Kao

et al.

eNeuro, Journal Year: 2024, Volume and Issue: unknown, P. ENEURO.0378 - 24.2024

Published: Dec. 3, 2024

A common impairment in aging is age-related hearing loss (presbycusis), which manifests as impaired spectrotemporal processing. Presbycusis can be caused by a dysfunction of the peripheral and central auditory system these dysfunctions might differ between sexes. To date, circuit mechanisms nervous responsible for remain mostly unknown. In cortex (ACtx), accompanied alteration normal inhibitory (GABA) neurotransmission changes excitatory (NMDA AMPA) synapses, but circuits are affected has been unclear. Here we investigated how cortical microcircuits change with age if sex-dependent differences existed. We performed laser-scanning photostimulation (LSPS) combined whole-cell patch clamp recordings from Layer (L) 2/3 cells primary (A1) young adult (2-3 months) aged (older than 18 male female CBA/CaJ mice have hearing. found that L2/3 animals display functional hypoconnectivity originating L4. Compared to mice, weaker connections L2/3. also observed an increased diversity inputs. These results suggest sex-specific reduction diversification intralaminar compared animals. speculate unbalanced contribute manifestations both males females. Significance Statement (presbycusis) system. Impaired processing thought underlie some impairments. compare vitro (∼P60) (∼P585) CBA mice. find differential

Language: Английский

Sex-specific age-related changes in excitatory and inhibitory intra-cortical circuits in mouse primary auditory cortex DOI Creative Commons
Zheng Xu, Binghan Xue, Joseph P. Y. Kao

et al.

eNeuro, Journal Year: 2024, Volume and Issue: unknown, P. ENEURO.0378 - 24.2024

Published: Dec. 3, 2024

A common impairment in aging is age-related hearing loss (presbycusis), which manifests as impaired spectrotemporal processing. Presbycusis can be caused by a dysfunction of the peripheral and central auditory system these dysfunctions might differ between sexes. To date, circuit mechanisms nervous responsible for remain mostly unknown. In cortex (ACtx), accompanied alteration normal inhibitory (GABA) neurotransmission changes excitatory (NMDA AMPA) synapses, but circuits are affected has been unclear. Here we investigated how cortical microcircuits change with age if sex-dependent differences existed. We performed laser-scanning photostimulation (LSPS) combined whole-cell patch clamp recordings from Layer (L) 2/3 cells primary (A1) young adult (2-3 months) aged (older than 18 male female CBA/CaJ mice have hearing. found that L2/3 animals display functional hypoconnectivity originating L4. Compared to mice, weaker connections L2/3. also observed an increased diversity inputs. These results suggest sex-specific reduction diversification intralaminar compared animals. speculate unbalanced contribute manifestations both males females. Significance Statement (presbycusis) system. Impaired processing thought underlie some impairments. compare vitro (∼P60) (∼P585) CBA mice. find differential

Language: Английский

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