Liposomes for Tumor Targeted Therapy: A Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2643 - 2643

Published: Jan. 31, 2023

Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional delivery systems, liposomes exhibit prominent properties that include targeted high biocompatibility, biodegradability, easy functionalization, low toxicity, improvements sustained release it carries and improved therapeutic indices. In wake rapid development nanotechnology, studies liposome composition have become increasingly extensive. The molecular diversity composition, which includes long-circulating PEGylated liposomes, ligand-functionalized stimuli-responsive advanced cell membrane-coated biomimetic nanocarriers, endows their unique physiological functions. This review describes types preparation methods discusses targeting strategies cancer therapy.

Language: Английский

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A comprehensive review on various techniques used for synthesizing nanoparticles

Journal of Materials Research and Technology, Journal Year: 2023, Volume and Issue: 27, P. 1739 - 1763

Published: Oct. 4, 2023

Nature is still the main focus of scientific and technological research, particularly in nanotechnology because its remarkable properties; has acquired much interest recent years. This review focuses on up-to-date overview classification nanoparticles, characterization, methods preparation, characterization application nanoparticles. Initial section gives insight various techniques for synthesis encompassing both bottom-up top-down approaches. Different nanoparticles are discussed details. Highlighting importance controlling shape, size, composition to develop enhance properties These include enhanced surface area, unique optical, electronic, magnetic characteristics, as well improved mechanical properties. Understanding these attributes essential harnessing different applications effectively. Broad spectrum also discussed. Additionally, have found catalysis, environmental remediation, antimicrobial coatings, contributing sustainable development protection. Overall, represent a progressive area research with tremendous potential innovation societal impact. Our evaluation will serve solid reference, assisting community comprehend topic better by showing role each technique comparable manner. As field constantly evolving, this incorporates latest developments, advancements up time publication. A comprehensive understanding their properties, decisive realizing full industrial domains.

Language: Английский

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Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics

ACS Nano, Journal Year: 2023, Volume and Issue: 17(23), P. 23223 - 23261

Published: Dec. 2, 2023

Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen species (ROS), glutathione (GSH), and pH, biological enzymes, external lasers ultrasound, etc., by changing their hydrophobicity/hydrophilicity, degradability, ionizability, thus have been widely used in biomedical applications. Due the characteristics of tumor microenvironment (TME), stimuli-responsive that cater specifically TME extensively prepare smart nanovehicles for targeted delivery therapeutic diagnostic agents tissues. Compared conventional drug nanosystems, TME-responsive nanosystems many advantages, high sensitivity, broad applicability among different tumors, functional versatility, improved biosafety. In recent years, a great deal research has devoted engineering efficient polymeric significant improvement made both cancer diagnosis therapy. this review, we summarize some advances involving use polymer nanocarriers delivery, imaging, therapy, theranostics. Various chemical stimuli will be described context nanosystems. Accordingly, groups responsible responsiveness strategies incorporate these into discussed detail. With on topic expending at fast pace, innovative concepts, sequential cascade release, NIR-II multifunctional formulations, emerged popular enhanced performance, which also included here with up-to-date illustrations. We hope review offer valuable insights selection optimization help accelerate future applications treatment.

Language: Английский

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Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 656 - 656

Published: Feb. 15, 2023

Skin delivery is an exciting and challenging field. It a promising approach for effective drug due to its ease of administration, handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, many other advantages. The main associated challenge, however, low skin permeability. healthy barrier that serves as the body's primary defence mechanism against foreign particles. New advances in (both topical transdermal) depend on overcoming challenges with molecule permeation irritation. These limitations can be overcome by employing new approaches such lipid nanosystems. Due their advantages (such easy scaling, cost, remarkable stability) these systems have attracted interest from scientific community. However, successful formulation, several factors including particle size, surface charge, components, etc. understood controlled. This review provided brief overview structure well different pathways nanoparticle penetration. In addition, influencing penetration nanoparticles been highlighted. Applications nanosystems dermal transdermal delivery, regulatory aspects, were critically discussed.

Language: Английский

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Advances in Glioblastoma Therapy: An Update on Current Approaches

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(11), P. 1536 - 1536

Published: Oct. 31, 2023

Glioblastoma multiforme (GBM) is a primary malignant brain tumor characterized by high grade of malignancy and an extremely unfavorable prognosis. The current efficacy established treatments for GBM insufficient, necessitating the prompt development novel therapeutic approaches. progress made in fundamental scientific understanding swiftly translated into more advanced stages studies. Despite extensive efforts to identify new approaches, exhibits mortality rate. patients insufficient due factors such as heterogeneity, blood–brain barrier, glioma stem cells, drug efflux pumps, DNA damage repair mechanisms. Considering this, pharmacological cocktail therapy has demonstrated growing addressing these challenges. Towards various forms immunotherapy, including immune checkpoint blockade, chimeric antigen receptor T (CAR T) cell therapy, oncolytic virotherapy, vaccine have emerged potential strategies enhancing prognosis GBM. Current investigations are focused on exploring combination therapies mitigate undesirable side effects enhance responses against tumors. Furthermore, clinical trials underway evaluate several circumvent barrier (BBB) achieve targeted delivery suffering from recurrent In this review, we described biological molecular targets pharmacologic status, prominent resistance mechanisms, treatment We also discuss promising approaches assess prospective innovative agents evaluated present state preclinical studies treatment. Overall, review attempts provide comprehensive information status therapy.

Language: Английский

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Skin drug delivery using lipid vesicles: A starting guideline for their development

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 355, P. 624 - 654

Published: Feb. 17, 2023

Lipid vesicles can provide a cost-effective enhancement of skin drug absorption when vesicle production process is optimised. It an important challenge to design the ideal vesicle, since their properties and features are related, as changes in one affect others. Here, we review main components, preparation characterization methods commonly used, key that lead highly efficient for transdermal delivery purposes. We stand by size, deformability degree loading, most determine further absorption. The interest this technology increasing, demonstrated exponential growth publications on topic. Although long-term preservation scalability issues have limited commercialization lipid products, freeze-drying modern escalation overcome these difficulties, thus predicting higher use technologies market clinical practice.

Language: Английский

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Drug Delivery Systems in Regenerative Medicine: An Updated Review

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 695 - 695

Published: Feb. 18, 2023

Modern drug discovery methods led to evolving new agents with significant therapeutic potential. However, their properties, such as solubility and administration-related challenges, may hinder benefits. Moreover, advances in biotechnology resulted the development of a generation molecules short half-life that necessitates frequent administration. In this context, controlled release systems are required enhance treatment efficacy improve patient compliance. Innovative delivery promising tools protect proteins peptides against proteolytic degradation where is achievable. The present review provides an overview different approaches used for delivery.

Language: Английский

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Recent advances in using liposomes for delivery of nucleic acid-based therapeutics

OpenNano, Journal Year: 2023, Volume and Issue: 11, P. 100132 - 100132

Published: Feb. 24, 2023

Nucleic acid therapeutics are rapidly expanding because of recent advancements in production and purification. This class may change the field disease treatment personalized medicine since it can cure diseases. However, drug delivery systems crucial for these to fulfill their potential. Liposomes have long been considered ideal platforms systemic drugs delivery. Considering development cancer therapeutics, this work emphases on current liposomes' Nano-formulations, functionalization, design how has applied nucleic therapeutics. Accordingly, review covers literature that deals with liposomes therapy.

Language: Английский

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Surface-modified bacteria: synthesis, functionalization and biomedical applications

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(19), P. 6617 - 6643

Published: Jan. 1, 2023

This review summarizes the strategies for surface chemical modification of bacteria and advanced functions achieved by modifying specific components highlights applications modified bioimaging, diagnosis, therapy.

Language: Английский

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Nanoparticles in cancer theragnostic and drug delivery: A comprehensive review

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899

Published: July 9, 2024

This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.

Language: Английский

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