Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(11), P. 1476 - 1476
Published: Nov. 2, 2024
Background:
The
triazole
ring
is
an
attractive
structural
unit
in
medicinal
chemistry,
and
chemical
compounds
containing
this
type
of
system
their
structure
exhibit
a
wide
spectrum
biological
activity.
They
are
used
the
development
new
pharmaceuticals.
One
basic
parameters
considered
initial
phase
designing
potential
drugs
lipophilicity,
which
affects
bioavailability
pharmacokinetics
drugs.
Methods:
study
aimed
to
assess
lipophilicity
fifteen
derivatives
aniline
using
reversed
thin
layer
chromatography
(RP-TLC)
free
web
servers.
Based
on
silico
methods,
drug
similarity
pharmacokinetic
profile
(ADMET)
synthesized
molecules
were
assessed.
Results:
A
relationship
was
observed
between
title
compound,
including
position
substitution
ring,
experimental
values
(logPTLC).
Most
algorithms
determine
theoretical
logP
showed
less
sensitivity
differences
tested
molecules.
All
obtained
satisfy
rules
formulated
by
Lipinski,
Ghose
Veber.
Moreover,
analysis
ADME
favorable
related
absorption.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 18, 2024
Abstract
Introduction:
The
purpose
of
this
study
was
to
investigate
the
synergistic
effect
thymol/ampicillin
on
Escherichia
coli
(E.
coli).
Material
and
methods
Antimicrobial
thymol,
ampicillin
individually
in
combination
with
different
concentrations
E.
ATCC25922
were
performed
by
MIC-MBC
method.
antimicrobial
a
compound
that
had
twenty
clinical
strains
bacteria
method,
identification
chemical
bonds,
functional
groups,
molecular
interactions
investigated
an
FTIR
device.
Checkered
time-killing
curve
biofilm
inhibition
bacteria,
investigation
cytotoxicity
human
red
blood
cells
(RBCs)
hemolysis
method
skin
fibroblast
(Ffk)
MTT
performed.
F1
effect.
Results
results
showed
effects
ampicillin,
(F1
compound),
256,
8,
8/2
µg/ml
(FICI:
1)
respectively.
128–512/32–64
time
for
killing
higher
combined
mode
than
individual
modes.
These
compounds
bonds
OH
carbohydrates
proteins,
polyphenols,
C
=
O
Amide
I
band,
C-O-Cpolysaccharide,
C-Namide
III
but
conjugated,
≡
compound,
shows
connection
between
thymol/ampicillin.
rate
against
29.69%,
60%,
62%
toxicity
RBCs
36.12,
8.38,
9.54,
Ffk
9.92,
6.83,
9.33
Discussion
Considering
resistance
treatment
diseases
caused
coli,
proved
has
high
anti-bacterial
anti-biofilm
properties.
Toxicity
several
same,
can
be
tested
later.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(11), P. 1476 - 1476
Published: Nov. 2, 2024
Background:
The
triazole
ring
is
an
attractive
structural
unit
in
medicinal
chemistry,
and
chemical
compounds
containing
this
type
of
system
their
structure
exhibit
a
wide
spectrum
biological
activity.
They
are
used
the
development
new
pharmaceuticals.
One
basic
parameters
considered
initial
phase
designing
potential
drugs
lipophilicity,
which
affects
bioavailability
pharmacokinetics
drugs.
Methods:
study
aimed
to
assess
lipophilicity
fifteen
derivatives
aniline
using
reversed
thin
layer
chromatography
(RP-TLC)
free
web
servers.
Based
on
silico
methods,
drug
similarity
pharmacokinetic
profile
(ADMET)
synthesized
molecules
were
assessed.
Results:
A
relationship
was
observed
between
title
compound,
including
position
substitution
ring,
experimental
values
(logPTLC).
Most
algorithms
determine
theoretical
logP
showed
less
sensitivity
differences
tested
molecules.
All
obtained
satisfy
rules
formulated
by
Lipinski,
Ghose
Veber.
Moreover,
analysis
ADME
favorable
related
absorption.
