Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101839 - 101839
Published: Oct. 4, 2024
Language: Английский
Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 184 - 184
Published: Feb. 1, 2024
Type 2 diabetes (T2D) is a major worldwide health crisis affecting about 6.2% of the world’s population. Alarmingly, one in five children USA have prediabetes. Glutathione (GSH) and its precursors play promising role prevention management type T2D. Oxidative stress (OxS) probable factor both T2D initiation progression. GSH cytosolic water-soluble chemical antioxidant emerging evidence supports improving outcomes. Dietary supplementation with N-acetyl-cysteine (NAC) and/or glycine (GLY), which are precursors, has also been studied for possible beneficial effects on This review will focus underlying pathophysiological molecular mechanisms linking OxS. In addition to their traditional roles, vivo GSH/NAC/GLY supplements be evaluated potential abilities modulate complex pro-oxidant factors (e.g., hyperglycemia) driving Positive feedback loops that amplify OxS over long time intervals likely result irreversible micro- macro-vascular damage. Most clinical studies focused adults or elderly. Future research pediatric populations should high priority since early intervention critical.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10606 - 10606
Published: Oct. 1, 2024
Honey is one of the most valuable components human diet. It considered to be a functional food with health-promoting properties. has bactericidal and bacteriostatic effects; used treat wounds ulcers; relieves stress; supports treatment diseases digestive respiratory systems; improves kidney function; aids in convalescence. The healing prophylactic effects honey are closely related its chemical composition. According literature, contains over 300 substances belonging various groups compounds, some antioxidant activity, including vitamins phenolic mainly flavonoids acids. This article provides insight into honey’s composition pro-health activities. properties were prioritized.
Language: Английский
Citations
9
Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 116, P. 106133 - 106133
Published: March 15, 2024
Edible flower of Hemerocallis citrina Baroni (H. citrina), commonly known as "Huang Huacai" in China, is a medicinal and edible vegetable with high nutritional value. Two major kinds secondary metabolites identified H. are flavonoids phenolic acids. have been found to possess beneficial effects including anti-inflammatory, antioxidant, anticancer, antidepressant, antimicrobial, anti-constipation, anti-aging, sleep-improving, lactation-promoting effects. These health benefits carried through various mechanisms different signaling pathways. However, the research on identification mechanism other types phytochemicals for not systematic in-depth. In addition, antidepressant actions show more significant flower, providing new insights future clinical medicine development. This reviews current status promoting theoretical basis exploitation utilization resources.
Language: Английский
Citations
7
World Journal of Advanced Research and Reviews, Journal Year: 2024, Volume and Issue: 23(1), P. 2724 - 2736
Published: July 30, 2024
This comprehensive review explores the intricate relationship between diabetes complications and foodborne diseases, focusing on nutritional interventions as a management strategy. Diabetes patients are particularly vulnerable to illnesses due compromised immune function altered gut microbiota. These infections can exacerbate existing trigger new ones. synthesizes current research approaches mitigate these risks manage complications. Key discussed include targeted probiotic supplementation, antioxidant-rich diets, specific micronutrient fortification. The examines mechanisms by which improve glycemic control, enhance function, promote health in diabetic individuals. It also potential of low index anti-inflammatory diets managing both susceptibility pathogens. challenges implementing interventions, such individual variability response difficulties maintaining long-term dietary changes, critically analyzed. Furthermore, review.
Language: Английский
Citations
4
Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 38 - 38
Published: Jan. 10, 2025
Background/Objectives: Gardeniae Fructus (GF) has been widely used as both food and medicinal purposes for thousands of years, but their antioxidant properties potential metabolite biomarkers remain unclear. Methods: The this study were to examine activities 21 GF varieties from different geographical origins in China identify using an untargeted LC-MS-based metabolomics approach. Results: results demonstrate that had the ability trace GF. We found varied with GF, which was dependent on chemical compositions. key categories obtained primary contributors activity, including prenol lipids, flavonoids, coumarins derivatives, well steroids steroid derivatives. In addition, adouetine Y, coagulin R 3-glucoside epicatechin identified activity Conclusions: Therefore, our sheds light metabolic characteristics contributing selection cultivation a high variety.
Language: Английский
Citations
0
Diabetology, Journal Year: 2025, Volume and Issue: 6(2), P. 9 - 9
Published: Feb. 5, 2025
Background: Diabetic foot ulcers (DFUs) represent a significant cause of morbidity in diabetic patients, with surgical management frequently required advanced cases. This study examines the association between preoperative vitamin C levels and wound-healing outcomes patients disease (DFD) requiring debridement. Methods: A retrospective cohort was conducted at tertiary referral centre, including who had undergone debridement for forefoot midfoot infections January 2020 July 2024. Patients ISDA grades 3 4 measurements C, albumin, HbA1c, BMI were included. The primary outcome time to wound healing, defined as duration from surgery discharge orthopaedic clinic. Data analysed using generalized linear models assess impact on healing time, controlling confounding variables. Results: In 61 included multivariable regression analysis, higher significantly associated faster (p = 0.01). Other factors albumin ulcer location, more slowly than ulcers. mean months, showing statistically effect outcomes. Conclusions: Our demonstrates that surgically treated Future prospective randomized controlled trials are needed confirm these findings role supplementation DFUs.
Language: Английский
Citations
0
OMICS A Journal of Integrative Biology, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
Type 2 diabetes (T2D) is characterized by relative insulin deficiency due to pancreatic beta cell dysfunction and resistance in different tissues. Not only cells but also other islet (alpha, delta, polypeptide [PP]) are critical for maintaining glucose homeostasis the body. In this overarching context given that a deeper understanding of T2D pathophysiology novel molecular targets much needed, studies integrate experimental computational biology approaches offer veritable prospects innovation. study, we report on single-cell RNA sequencing data integration with generic Human1 model generate context-specific genome-scale metabolic models alpha, beta, PP nondiabetic states and, importantly, at resolution. Moreover, flux balance analysis was performed investigation activities cells. By altering oxygen uptakes networks, documented ways which hypoglycemia, hyperglycemia, hypoxia led changes various cellular subsystems. Reporter metabolite revealed significant transcriptional around several metabolites involved sphingolipid keratan sulfate metabolism alpha cells, fatty acid myoinositol phosphate delta Taken together, leveraging modeling, research bridges gap between theory clinical practice, offering comprehensive framework advance our T2D, contributes new knowledge toward development targeted precision medicine interventions.
Language: Английский
Citations
0
Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 102015 - 102015
Published: March 28, 2025
Sweet potato (Ipomoea batatas L.) is a nutrient-dense tuber often used in traditional diabetic treatment. This research compares the antidiabetic potential of three sweet varieties: orange-fleshed (OFSP), purple-peel white-fleshed (PPWSP), and white-peel (WPWSP), utilising vitro vivo techniques. potatoes (OFSP, PPWSP, WPWSP) boiled at 100°C for 20 minutes were incorporated into formulated diets administered to streptozotocin-induced rats 14 days. Aqueous extracts tested antioxidants phytochemicals. Glycaemic control parameters, lipid profiles, oxidative stress indicators, pancreatic histology investigated. Gene expression analysis was performed on critical diabetes-related pathways. OFSP showed significant strong anti-diabetic benefits, including better glycemic control, weight maintenance, lower HOMA-IR scores, lowered α-amylase α-glucosidase activity. OFSP-fed had higher insulin, glycogen, hexokinase activity than those given PPWSP WPWSP. decreased mRNA DPP-4 while increasing GLP-1 expression. also improved HDLc decreasing LDLc triglycerides more other varieties. Histopathological examination revealed restorative effects beta cells. demonstrated pronounced compared WPWSP, particularly terms insulin regulation, profile improvement. These findings suggest that may offer diabetes management. However, further clinical studies are needed validate these results explore practical dietary applications control.
Language: Английский
Citations
0
Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(4)
Published: April 1, 2025
Trevesia Vis. species are small evergreen trees belonging to the family Araliaceae that occur naturally throughout Asia. The multiple parts of have been used in traditional medicinal systems several countries for their potential therapeutic properties, including pain relief, inflammation, fevers, microbial infections, diabetes, cancer, edema, bone fractures, and arthritis. This work presents a fascinating exploration previous studies on species, especially T. palmata , delving into phytochemical constituents, biological activities, toxicology, inviting you uncover further. paper database meticulously compiles valuable data gathered from all accessible literature between 1842 2024 through wide range resources, Web Science, Scopus, Google Scholar, PubMed, Science Direct, Springer, other scientific databases, ensuring comprehensive reliable overview research species. Various bioactive phytochemicals, such as triterpenoid saponins, flavonoids, phenolic compounds, found these plants. Chemotaxonomic investigations revealed genus may be closely related genera Aralia Acanthopanax Hedera . Pharmacological showed extracts phytocompounds exhibit various antiproliferative, anticancer, antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory, antidiabetic, analgesic, thrombolytic, hepatoprotective activities. Moreover, numerous toxicological reports safety plant. For first time, this highlights role effects health benefits food medicine while also providing an current study status future prospects mainly
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0319756 - e0319756
Published: April 9, 2025
Together with their nutritional qualities, the biosafety, antidiabetic, antioxidant, and anti-inflammatory effects of Tetracarpidium conophorum nuts, Persea americana seeds, Terminalia cattapa kernels were evaluated in vitro silico. RBC membrane stabilisation for characteristics, antioxidant activities by ABTS, DPPH, H2O2, nitric oxide scavenging assays, α-glucosidase α-amylase inhibitory assays conducted used to evaluate anti-diabetic activity. With an IC50 value 208 μg/mL , P. showed maximum amount inhibition, according results, while T. catappa a somewhat lower degree inhibition at 236 . exhibited highest 312 µg/mL. strongest DPPH radical activity, ABTS effectiveness neutralising hydrogen peroxide. In tests using human red blood cells, hemolysis. While higher concentrations copper, manganese, potassium, calcium, magnesium concentrations. had considerably levels ash, proteins, lipids, carbohydrates than which quantity crude fibre, proximate analysis. Molecular docking experiments have revealed that plant extracts from americana, substantial binding affinities towards amylase. Pseudococaine, M-(1-methylbutyl) phenylmethylcarbamate, o-xylene, 1-deoxynojirimycin four compounds those acarbose. Acarbose nitrate not as compatible scores compared dimethyl phthalate, pseudococaine, M-(1-Methylbutyl)phenyl methylcarbamate, 2-chloro-3-oxohexanedioic acid, methyl 2-chloro-5-nitrobenzoate. These results suggest these hold great potential creation therapeutic medications specifically target oxidative stress-related diseases like diabetes.
Language: Английский
Citations
0