Therapeutic approaches targeting aging and cellular senescence in Huntington's disease

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(10)

Published: Oct. 1, 2024

Huntington's disease (HD) is a devastating neurodegenerative that manifested by gradual loss of physical, cognitive, and mental abilities. As the advances, age has major impact on pathogenic signature mutant huntingtin (mHTT) protein aggregation. This review aims to explore intricate relationship between aging, mHTT toxicity, cellular senescence in HD. Scientific data interplay mHTT, HD were collected from several academic databases, including PubMed, Google Scholar, Google, ScienceDirect. The search terms employed "AGING," "HUNTINGTON'S DISEASE," "MUTANT HUNTINGTIN," "CELLULAR SENESCENCE." Additionally, gather information molecular mechanisms potential therapeutic targets, was extended include relevant such as "DNA DAMAGE," "OXIDATIVE STRESS," "AUTOPHAGY." According research, aging leads worsening pathophysiology through some processes. result accumulation, promoted, which causes DNA damage, oxidative stress, decreased autophagy, increased inflammatory responses. Pro-inflammatory cytokines other substances are released senescent cells, may worsen neuronal damage course disease. It been shown treatments directed at these pathways reduce symptoms enhance longevity experimental animals, pointing new possibility treating condition. Through their amplification harmful effects play crucial roles development Comprehending interplays creates novel opportunities for measures targeted alleviating enhancing patients' quality life.

Language: Английский

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Biomarkers in rosacea: A systematic review

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2023, Volume and Issue: 38(6), P. 1048 - 1057

Published: Dec. 11, 2023

Abstract Rosacea is a chronic and psychologically ladened disease affecting 1%–3% of people worldwide. The identification validation biomarkers in rosacea patients has the potential to improve progression, support diagnosis, provide objective measures for clinical trials aid management. this review systematically identify all biomarkers, categorize them by type trends expression. Eligibility criteria (PROSPERO CRD42023397510) include randomized controlled trials, case–control studies, cohort studies other observational studies. No restrictions were placed on patient demographics (age, sex, ethnicity) or language publication until February 2023. Quality was assessed using National Institute Health quality assessment tool. literature search conducted according Preferred Reporting Items Systematic Reviews Meta‐analyses (PRISMA) guidelines. A total 805 unique articles screened based applied inclusion exclusion criteria. After title/abstract full‐text, 38 included, reporting 119 biomarkers. results current pathogenic mechanisms greatest innate cathelicidin inflammasome, T h 1 17 pathways. most commonly reported IL‐1β, TNF‐α, IL‐37, IFN‐γ MMP‐9. Biomarkers identified study theories pathogenesis direction research further our knowledge. However, more needed panels that can diagnostic utility. This may be difficult due heterogeneity differences between subtypes.

Language: Английский

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Signaling redox probe/DNA aptamer complexes on a new POP/2D WSe2 composite-based immunosensor towards the simultaneous detection of three-protein overexpression as an alternative severe SARS-COV-2 infection diagnosis

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 404, P. 135196 - 135196

Published: Dec. 21, 2023

Language: Английский

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Multiplexed electrochemical sensing devices for chronic diseases diagnosis and monitoring

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 172, P. 117560 - 117560

Published: Feb. 8, 2024

Language: Английский

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Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155224 - 155224

Published: Feb. 23, 2024

Language: Английский

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