Medicinal Herbs: Promising Immunomodulators for the Treatment of Infectious Diseases

Molecules, Journal Year: 2023, Volume and Issue: 28(24), P. 8045 - 8045

Published: Dec. 12, 2023

Humans are constantly at high risk of emerging pandemics caused by viral and bacterial infections. The emergence new is mainly evolved viruses bacteria that highly resistant to existing medications. rapid evolution infectious agents demands the urgent investigation therapeutic strategies prevent treat these infections an early stage. One includes use medicinal herbs for their antibacterial antiviral properties. herbal medicines as remedies very ancient has been employed centuries. Many studies have confirmed antimicrobial activities against various pathogens in vitro vivo. effect attributed natural bioactive molecules present plants such alkaloids, flavonoids, terpenoids. Different mechanisms proposed how enhance immune system combat pathogens. Such include disruption cell membranes, suppression protein synthesis, limitation pathogen replication through inhibition nucleic acid synthesis. Medicinal shown a number diseases modulating system's components. For instance, many alleviate inflammation reducing pro-inflammatory cytokines (e.g., tumor necrosis factor-alpha (TNF-α), interleukin-1, IL-6) while promoting production anti-inflammatory IL-10). also play role defense intracellular enhancing proliferation functions killer cells, T-helper-1 macrophages. In this review, we will explore most common preventing treating non-infectious diseases. Using current recently published studies, focus on immunomodulatory effects induced responses during

Language: Английский

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An Overview of Bioactive Components and Phytopharmaceutical Potentials of Hygrophila auriculata- A Herbaceous Medicinal Plant

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100737 - 100737

Published: Jan. 1, 2025

Language: Английский

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Drugs Discovery from Traditional Phytotherapy

Published: April 29, 2025

BACKGROUND. Phytotherapy refers to the use of plant extracts for therapeutic purpose. It plays important role in ancient medicine practices. has been considered as a cornerstone development modern drugs. With advancement field science and technology, researchers systematically evaluate medicinal properties plants. OBJECTIVE. is an integrative approach that integrates traditional knowledge with techniques identification, isolation, test derivative compounds. Literature on plant-derived natural products used suitable precursors drug discovery was included. METHODS. The data source were obtained through literature publications using different scientific search engines. RESULTS. These papers carefully evaluated, critically analyzed structured accurate information. process begins ethnobotanical surveys study select promising potential herb. Phytochemical methods are then employed extract isolate active constituents. phytotherapy drugs have plants support health manage various conditions. Recently analytical chemistry genomics essential accelerating process. High-throughput screening, molecular docking, bioinformatics tools enabled rapid identification bioactive Traditional significantly influenced by providing wealth about plant-based remedies. Many pharmaceuticals roots herbal practices, compounds isolated from forming basis effective treatments. CONCLUSION. This integration wisdom research led targeted therapies, emphasizing importance discovery. As continue explore compounds, remains vital new medicines. Moreover, advancements pharmacokinetics pharmacodynamics improved understanding interact biological systems, enhancing their efficacy safety profiles.

Language: Английский

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Liver Disorders and Phytotherapy

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102047 - 102047

Published: May 1, 2025

Language: Английский

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Adaptogenic action of diosgenin againsts chronic unpredictable mild stress-induced neuroimmune dysfunction of HPA axis reverses psychiatric behavior in mice

Deleted Journal, Journal Year: 2024, Volume and Issue: 5(2), P. 200148 - 200148

Published: April 27, 2024

Language: Английский

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Characterization, phytochemical profiling, antioxidant, and cytotoxicity of underutilized medicinal plants and composite flour

Food Chemistry, Journal Year: 2024, Volume and Issue: 456, P. 139985 - 139985

Published: June 6, 2024

Language: Английский

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An Updated Insight on the Chemistry, Ethnobotany, and Health Benefits of Asparagus racemosus (Shatavari): With a Special Emphasis on Shatavarin IV

Journal of the American Nutrition Association, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: May 7, 2025

Asparagus racemosus, more famous as Shatavari, is a popular medicinal plant with broad species distribution across the Indian subcontinent well globe. The multidimensional therapeutic potential of this herb has earned it title "Queen Herbs." Shatavari rich in bioactive constituents including alkaloids, carboxylic acids, polycyclic hydrocarbons, isoflavones, flavonoids, dihydrophenanthrene derivatives, furan essential oils, sterols, and steroidal saponin (specifically Shatavarin-I to VI), distributed throughout rhizome other parts plant. These compounds are frequently used treatment several medical conditions, dysentery, diabetic retinopathy, hypertension, anxiety disorders, inflammation, tumors, mental hyperacidity, viral diseases, spasms, chronic fever, rheumatism. In addition, possesses antibacterial, adaptogenic, antioxidant properties. Shatavarin IV, sarsapogenin enriched roots especially beneficial for women's reproductive health also acts an effective stressbuster. It remedy female infertility by boosting libido, managing sexual organ facilitating folliculogenesis ovulation, preparing uterus conception, preventing miscarriages, functioning postpartum tonic enhancing lactation restoring uterine hormonal homeostasis. regard, novel root formulation, Shevari4T®, been developed, IV content exceeding 7.4%, which promises deliver goodness women. This review provides comprehensive insight into holistic benefits particular emphasis on IV.Key teaching pointsAsparagus racemosus (Shatavari) perennial climber containing multiple selected saponins, namely, I - VI.Shatavarin most potent glycosides found abundance plant.Shatavarin comprising two molecules rhamnose one glucose molecule, basically glycoside sarsasapogenin.Shatavarin from exhibits pharmacological effects antioxidant, anti-cancer, anti-inflammatory, cardioprotective, immunomodulatory, neuroprotective, antidiabetic antihypertensive properties.It augments fertility reproduction

Language: Английский

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Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1129 - 1129

Published: May 7, 2025

Background/Objectives: Major depressive disorder (MDD) is a major global health concern that intimately linked to neuroinflammation, oxidative stress, mitochondrial dysfunction, and complicated metabolic abnormalities. Traditional antidepressants frequently fall short, highlighting the urgent need for new, safer, more acceptable therapeutic techniques. Phytochemicals, i.e., natural derived from plants, are emerging as powerful plant-based therapies capable of targeting many pathogenic pathways at same time. Summary: This narrative review synthesizes evidence preclinical clinical studies on efficacy phytochemicals such curcumin, polyphenols, flavonoids, alkaloids in lowering depressed symptoms. Consistent data show these substances have neuroprotective, anti-inflammatory, antioxidant properties, altering neuroimmune interactions, reducing damage, improving resilience. Particularly, polyphenols flavonoids great potential because their capacity penetrate blood–brain barrier, inhibit cytokine activity, encourage neuroplasticity mediated by brain-derived neurotrophic factor (BDNF). Despite promising results, heterogeneity study designs, phytochemical formulations, patient demographics highlights importance thorough, standardized studies. Conclusions: identifies compelling adjuvant or independent depression treatment, providing multimodal mechanisms enhanced tolerability. Additional research into improved dosage, pharmacokinetics, long-term safety, integrative therapy approaches essential. Using phytotherapeutics could considerably improve holistic customized care, encouraging new routes neuroscience psychiatry.

Language: Английский

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Plants used in female reproductive healthcare by the Gujjar tribe of the sub-Himalayan region of Uttarakhand, India

Journal of Herbal Medicine, Journal Year: 2023, Volume and Issue: 42, P. 100786 - 100786

Published: Sept. 26, 2023

Language: Английский

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Enhanced In Vitro Plant Morphogenesis of Tobacco: Unveiling Indoleamine-Modulated Adaptogenic Properties of Tulsi (Ocimum sanctum L.)

Plants, Journal Year: 2024, Volume and Issue: 13(10), P. 1370 - 1370

Published: May 15, 2024

The medicinal plant tulsi (Ocimum sanctum L.) is acknowledged for its invigorating and healing properties that enhance resilience to stress in various human animal models by modulating antioxidant compounds. While extensive research has documented these effects humans, the adaptogenic potential of stressful vitro systems not been explored. This study aimed elucidate leaf extract on regeneration tobacco explants through an investigation indoleamines at different developmental stages. Shoot from medium supplemented with (20%) was compared control, differences indoleamine compounds were analyzed using ultra-performance liquid chromatography. Treatment resulted almost two-fold increase number regenerants after four weeks culture, 9% resembled somatic embryo-like structures. occurrence browning extract-treated stopped day 10, shoots began develop, a significant concentration tryptamine N-acetyl-serotonin accumulated. A comparative analysis intact cut leaves also revealed pivotal role melatonin 2-hydroxymelatonin functioning as antioxidants during adaptation. demonstrates potent adaptogen capable morphogenesis vitro, paving way further investigations into adaptogens biology.

Language: Английский

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