ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(37)
Published: Oct. 2, 2023
Abstract
In
the
present
work,
green
synthesis
is
utilized
in
of
silver
nanoparticles
with
hazelnut
(Corylus
Colurna)
husk
which
outer
leaf
part
shell
and
considered
bio‐waste.
According
to
transmission
electron
microscopy
x‐ray
diffraction
analysis,
morphology
synthesized
by
0.1
g/mL
extract
found
be
spherical
an
average
diameter
6.57
nm
possesses
ultra‐narrow
size
distribution.
UV‐visible
spectrometry
reveals
absorbance
peak
range
between
450–475
surface
plasmon
resonance
morphology.
Antibacterial
properties
were
tested
on
E.
coli
significant
antimicrobial
activity
was
up
79
%
areal
inhibition
efficiency.
The
research
revealed
that
extract,
a
reducing
agent
used
syntheses
different
mass
concentrations
also
affects
nanoparticles,
allowing
for
possibility
controlling
their
size.
antibacterial
form
sizes,
correspondingly
increased
effect
bacteria
observed
zone.
can
many
fields
agriculture,
cosmetics,
medical
purposes,
using
plant
minimal
chemicals
crucial
because
it
its
toxicity.
not
only
reduces
chemical
waste
toxicity,
but
both
easily
accessible
helps
environment
sustainability
recycling
normally
bio‐waste
by‐product
high‐value‐added
crop
technologically
valuable
product
silver.
Moreover,
could
essential
applications
ranging
from
treatments
drug
delivery
systems.
ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(40)
Published: Oct. 24, 2023
Abstract
The
continuous
upsurge
in
drug
resistance,
the
proliferation
of
life‐threatening
aliment,
and
advent
utilization
biogenic
extract
for
bio‐fabrication
metallic
nanoparticles
(MNPs)
are
unequivocally
accidental.
This
review
generously
gathers
efficacy
remarks
numerous
biosynthesized
MNPs
concerning
their
antithrombolytic
activity,
Anticoagulant
antiplatelet
activity
to
give
fresh
thought
researchers
on
what
improve
as
per
architectural
design
MNPs,
selection
better
activities.
In
this
work,
efforts
were
made
provide
mechanistic
insight
into
antithrombolytic,
Anticoagulant,
activities
different
MNPs.
work
revealed
that
used
synthesizing
green
confers
them
an
improved
biological
compared
physically
chemically
synthesized
MNP
owing
enormous
phytochemicals
present
entities.
Notably,
it
was
also
observed
phytogenically
performed
than
mycogenically
might
be
ascribed
a
large
volume
phytochemical
plants
can
easily
leached
microorganisms.
Comparatively,
synergistically
outperformed
ordinary
when
individually.
Conclusively,
from
review,
is
promising
candidate
combating
inflammation,
spread
infectious
agents,
retarded
wound‐healing
process,
thrombosis,
blood
coagulation,
ulcer,
internal
external
bleeding
during
injury
with
average
remarkable
>70,
infinitesimal
toxicity.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 4299 - 4317
Published: May 1, 2024
Background:
Inhibition
of
amyloid
β
protein
fragment
(Aβ)
aggregation
is
considered
to
be
one
the
most
effective
strategies
for
treatment
Alzheimer's
disease.
(-)-Epigallocatechin-3-gallate
(EGCG)
has
been
found
in
this
regard;
however,
owing
its
low
bioavailability,
nanodelivery
recommended
practical
applications.
Compared
chemical
reduction
methods,
biosynthesis
avoids
possible
biotoxicity
and
cumbersome
preparation
processes.
Materials
Methods:
The
interaction
between
EGCG
Aβ
42
was
simulated
by
molecular
docking,
green
tea-conjugated
gold
nanoparticles
(GT-Au
NPs)
EGCG-Au
NPs
were
synthesized
using
EGCG-enriched
tea
solutions,
respectively.
Surface
active
molecules
particles
identified
analyzed
various
liquid
chromatography-tandem
triple
quadrupole
mass
spectrometry
methods.
ThT
fluorescence
assay,
circular
dichroism,
TEM
used
investigate
effect
on
inhibition
aggregation.
Results:
as
well
apigenin,
quercetin,
baicalin,
glutathione
capping
ligands
stabilized
surface
GT-Au
NPs.
They
more
or
less
inhibited
promoted
fibril
disaggregation,
with
being
effective,
which
bound
through
hydrogen
bonding,
hydrophobic
interactions,
etc.
resulting
39.86%
88.50%
disaggregation
effects,
not
free
EGCG,
whereas
multiple
thiols
polyphenols
accelerated
optimized
heavy
metal
detoxification.
conferred
efficacy
diverse
particles,
effects
54.69%
88.75%,
respectively,
while
increasing
yield,
enhancing
water
solubility,
decreasing
cost.
Conclusion:
Biosynthesis
a
promising
simple
economical
drug-carrying
approach
confer
pharmacophore
Au
This
could
design
new
drug
candidates
treat
Keywords:
nanoparticles,
synthesis,
(-)-epigallocatechin-3-gallate,
chromatography
tandem
spectrometry,
protein,
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Jan. 1, 2025
Abstract
Rising
antibiotic
resistance
among
periodontal
pathogens
poses
a
major
challenge
to
treatment
outcomes.
This
work
investigates
the
possible
combinatorial
potential
of
AgNPs
synthesized
using
glycyrrhizin,
natural
biosurfactant,
combat
biofilm‐forming
bacteria
isolated
from
periodontitis
patients.
In
silico
findings
revealed
that
glycyrrhizin
had
higher
binding
affinity
score
‐9.102
compared
doxycycline
(−3.599)
for
gtfB
,
plays
an
indispensable
function
in
biofilm
integrity.
were
and
optimized
utilizing
design
experiments,
considering
factors
such
as
pH,
temperature,
incubation
time
concentration
variables.
while
The
resulting
GL‐AgNPs
characterized
by
different
analytical
techniques
FTIR,
XRD,
DLS,
SEM.
nanoparticles
non‐spherical,
uniform
average
size
72
nm,
zeta
potentials
ranged
−28
mV
−
42
mV.
Antimicrobial
suggested
exhibited
significant
antibacterial
anti‐biofilm
activity
prepared
sodium
borohydride
(
p
<
0.001).
Experimental
inhibited
formation
attenuating
Gtfase
activity.
Further,
show
effective
anti‐inflammatory
with
minimal
cytotoxicity.
Overall,
this
study
highlights
inherent
antimicrobial
surfactant
properties
greatly
improve
AgNPs,
providing
promising
approach
combating
biofilm‐producing
oral
periodontitis.
