Sustained Release of Voriconazole Using 3D-Crosslinked Hydrogel Rings and Rods for Use in Corneal Drug Delivery DOI Creative Commons
Aiym Rakhmetova,

Zhiqi Yi,

Malake Sarmout

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(12), P. 933 - 933

Published: Nov. 28, 2023

Corneal disorders and diseases are prevalent in the field of clinical ophthalmology. Fungal keratitis, one major factors leading to visual impairment blindness worldwide, presents significant challenges for traditional topical eye drop treatments. The objective this study was create biocompatible 3D-crosslinked hydrogels drug delivery cornea, intending enhance bioavailability ophthalmic drugs. Firstly, a series flexible porous were synthesized (free-radical polymerization), characterized, evaluated. materials prepared by free-radical polymerization reaction 1-vinyl-2-pyrrolidinone (also known as N-vinylpyrrolidone or NVP) 1,6-hexanediol dimethacrylate (crosslinker) presence polyethylene glycol 1000 (PEG-1000) porogen. After physicochemical characterization these materials, chosen hydrogel demonstrated outstanding cytocompatibility vitro. Subsequently, selected could be loaded with voriconazole, an antifungal medication. procedure adapted realize loading 175 mg voriconazole per ring, which slightly exceeds amount that is instilled into via therapy (a single corresponds approximately 100 voriconazole). voriconazole-loaded rings exhibited stable zero-order release pattern over first two hours, points significantly improved drug. Ex vivo experiments using established porcine model provided confirmation 10-fold increase penetration cornea (after 2 h application 35.8 ± 3.2% original dose retrieved from compares 3.9 1% case therapy). These innovative rods show great potential improving drugs, potentially lead reduced hospitalization durations treatment expenses.

Language: Английский

Influence of Neutral and Cationic Phytoglycogen Nanoparticles on Cartilage and Ocular Lubrication DOI Creative Commons

Nikola R. Mazarevica,

Yong Chen, Ke Ren

et al.

Biosurface and Biotribology, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 1, 2025

ABSTRACT Compromised hydration and biolubrication leads to untreatable disorders like osteoarthritis (OA), dry eye disease (DED) mouth (xerostomia). Only symptomatic treatment is possible through bioactive molecules. This study aims investigate the properties of natural modified phytoglycogen nanoparticles (PGNPs) which have shown superlubricious behaviour at mica‐mica sliding interface. PGNPs were cationised (CPGNPs) by modifying hydroxyl groups into quaternary amine groups. Dynamic light scattering (DLS) was used characterise size zeta‐potential both PGNPs. The quartz crystal microbalance with dissipation (QCM‐D) their adhesion collagen type II mucin. tribological studied using polydimethylsiloxane (PDMS)‐glass system, cartilage‐glass (synovial) eye‐eyelid (ocular) systems. CPGNPs adhered better than on synovial ocular surfaces. Both particle types showed good lubrication for cartilage but no differences between in system observed. Overall, observed lubricating indicating great potential towards a implementation osteoarthritis.

Language: Английский

Citations

0
Sustained Release of Voriconazole Using 3D-Crosslinked Hydrogel Rings and Rods for Use in Corneal Drug Delivery DOI Creative Commons
Aiym Rakhmetova,

Zhiqi Yi,

Malake Sarmout

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(12), P. 933 - 933

Published: Nov. 28, 2023

Corneal disorders and diseases are prevalent in the field of clinical ophthalmology. Fungal keratitis, one major factors leading to visual impairment blindness worldwide, presents significant challenges for traditional topical eye drop treatments. The objective this study was create biocompatible 3D-crosslinked hydrogels drug delivery cornea, intending enhance bioavailability ophthalmic drugs. Firstly, a series flexible porous were synthesized (free-radical polymerization), characterized, evaluated. materials prepared by free-radical polymerization reaction 1-vinyl-2-pyrrolidinone (also known as N-vinylpyrrolidone or NVP) 1,6-hexanediol dimethacrylate (crosslinker) presence polyethylene glycol 1000 (PEG-1000) porogen. After physicochemical characterization these materials, chosen hydrogel demonstrated outstanding cytocompatibility vitro. Subsequently, selected could be loaded with voriconazole, an antifungal medication. procedure adapted realize loading 175 mg voriconazole per ring, which slightly exceeds amount that is instilled into via therapy (a single corresponds approximately 100 voriconazole). voriconazole-loaded rings exhibited stable zero-order release pattern over first two hours, points significantly improved drug. Ex vivo experiments using established porcine model provided confirmation 10-fold increase penetration cornea (after 2 h application 35.8 ± 3.2% original dose retrieved from compares 3.9 1% case therapy). These innovative rods show great potential improving drugs, potentially lead reduced hospitalization durations treatment expenses.

Language: Английский

Citations

2