Investigating the role of KARS in lung adenocarcinoma via single-cell RNA sequencing DOI Creative Commons

Huafang Hu,

Yan Zhong,

G Li

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 3, 2024

Lung Adenocarcinoma (LUAD) is one of the leading causes to cancer-related deaths worldwide and exhibited extensive molecular diversity in its cellular components. In summary, this study examined expression function KARS various LUAD cell populations using single-cell RNA sequencing (scRNA-seq) identify prognostic value as well potential implications for therapy. All datasets related were analyzed previous published studies, which was downloaded from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression(GTEx) project Gene Expression Omnibus (GEO). We subsequently sought analyze association between either clinically tumorigenic or low survival-grade expression, respectively with varied clinicopathological features all patients OS. Verification performed by vitro RT-PCR. Our investigation found that markedly elevated tissue samples compared normal controls. Genomic analysis indicated a robust increased copy number gene overexpression. upregulation also correlated distinct genetic mutations higher mutational load LUAD. heightened activity implicated progression. Furthermore, our research significant interplay KARS's role tumor's immune microenvironment, along dimensions tumor immunology landscape. Comprehensive assessments within microenvironment uncovered pronounced link responses presence specific types. A549 line than 16HBE line. Utilizing omics technologies, offers detailed perspective on LUAD, highlighting biomarker candidate tailored therapeutic intervention. Future should probe possible strategies could target pathologically relevant manner.

Language: Английский

Assessing the necessity of screening ≤5 Mb segmental aneuploidy in routine PGT for aneuploidies DOI
Jiaqi Zhang, Meng Qin,

Mochen Ma

et al.

Reproductive BioMedicine Online, Journal Year: 2024, Volume and Issue: 49(3), P. 103991 - 103991

Published: April 11, 2024

Language: Английский

Citations

0
Investigating the role of KARS in lung adenocarcinoma via single-cell RNA sequencing DOI Creative Commons

Huafang Hu,

Yan Zhong,

G Li

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 3, 2024

Lung Adenocarcinoma (LUAD) is one of the leading causes to cancer-related deaths worldwide and exhibited extensive molecular diversity in its cellular components. In summary, this study examined expression function KARS various LUAD cell populations using single-cell RNA sequencing (scRNA-seq) identify prognostic value as well potential implications for therapy. All datasets related were analyzed previous published studies, which was downloaded from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression(GTEx) project Gene Expression Omnibus (GEO). We subsequently sought analyze association between either clinically tumorigenic or low survival-grade expression, respectively with varied clinicopathological features all patients OS. Verification performed by vitro RT-PCR. Our investigation found that markedly elevated tissue samples compared normal controls. Genomic analysis indicated a robust increased copy number gene overexpression. upregulation also correlated distinct genetic mutations higher mutational load LUAD. heightened activity implicated progression. Furthermore, our research significant interplay KARS's role tumor's immune microenvironment, along dimensions tumor immunology landscape. Comprehensive assessments within microenvironment uncovered pronounced link responses presence specific types. A549 line than 16HBE line. Utilizing omics technologies, offers detailed perspective on LUAD, highlighting biomarker candidate tailored therapeutic intervention. Future should probe possible strategies could target pathologically relevant manner.

Language: Английский

Citations

0