Nanotechnology in the diagnostic and therapy for Alzheimer's disease

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2024, Volume and Issue: 1868(3), P. 130559 - 130559

Published: Jan. 6, 2024

Language: Английский

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Enhanced cytotoxic efficacy against MCF-7 and HCT116 cell lines and high-performance cefoperazone removal using biogenically synthesized CeO2 nanoparticles

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139261 - 139261

Published: July 10, 2024

Language: Английский

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Nanoplatforms Targeting Intrinsically Disordered Protein Aggregation for Translational Neuroscience Applications

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(10), P. 704 - 704

Published: May 8, 2025

Intrinsically disordered proteins (IDPs), such as tau, beta-amyloid (Aβ), and alpha-synuclein (αSyn), are prone to misfolding, resulting in pathological aggregation propagation that drive neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s (PD). Misfolded IDPs aggregate into oligomers fibrils, exacerbating progression by disrupting cellular functions the central nervous system, triggering neuroinflammation neurodegeneration. Furthermore, aggregated exhibit prion-like behavior, acting seeds released extracellular space, taken up neighboring cells, have a propagating pathology across different regions of brain. Conventional inhibitors, small molecules, peptides, antibodies, face challenges stability blood–brain barrier penetration, limiting their efficacy. In recent years, nanotechnology-based strategies, multifunctional nanoplatforms or nanoparticles, emerged promising tools address these challenges. These leverage tailored designs prevent remodel reduce associated neurotoxicity. This review discusses advances designed target Aβ, αSyn aggregation, with focus on roles reducing We examine critical aspects nanoplatform design, choice material backbone targeting moieties, which influence interactions IDPs. also highlight key mechanisms interaction between inhibit redirect cascade towards nontoxic, off-pathway species, disrupt fibrillar structures soluble forms. further outline future directions for enhancing IDP clearance, achieving spatiotemporal control, improving cell-specific targeting. nanomedicine strategies offer compelling paths forward developing more effective targeted therapies diseases.

Language: Английский

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From experimental studies to computational approaches: recent trends in designing novel therapeutics for amyloidogenesis

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

This review highlights the integration of various experimental and computational methods to control amyloid aggregation process. We believe that this article will help researchers develop novel therapeutic influence protein aggregation.

Language: Английский

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Yttrium Doped Cerium Nanocomposites: Synthesis, Characterization, and Assessment of Toxicity in Drosophilamelanogaster

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

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Dopaminergic- and Serotonergic-Dependent Behaviors Are Altered by Lanthanide Series Metals in Caenorhabditis elegans

Toxics, Journal Year: 2024, Volume and Issue: 12(10), P. 754 - 754

Published: Oct. 17, 2024

The lanthanide series elements are transition metals used as critical components of electronics, well rechargeable batteries, fertilizers, antimicrobials, contrast agents for medical imaging, and diesel fuel additives. With the surge in their utilization, being found more our environment. However, little is known about health effects associated with exposure. Epidemiological studies performed rodents exposed to lanthanum (La) suggest neurological damage, learning memory impairment, disruption neurotransmitter signaling, particularly serotonin dopamine pathways. Unfortunately, heavier lanthanides. As dysfunctions serotonergic dopaminergic signaling implicated multiple conditions, including Parkinson’s disease, depression, generalized anxiety disorder, post-traumatic stress it utmost importance determine La other lanthanides on these systems. We therefore hypothesized that early-life exposure light [La (III) or cerium (Ce (III))] heavy [erbium (Er (III)) ytterbium (Yb Caenorhabditis elegans could cause dysregulation upon adulthood. Serotonergic was assessed by measuring pharyngeal pump rate, crawl-to-swim transition, egg-laying behaviors. Dopaminergic locomotor rate swim-to-crawl Treatment (III), Ce Er Yb caused deficits all assays, suggesting both disrupt Concomitant neurotransmission, four increased reactive oxygen species (ROS) generation decreased glutathione ATP levels. This suggests oxidative stress, which a modifier neurotransmission. Altogether, data may affect development pharmacological management related conditions.

Language: Английский

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Evaluation of Nanomaterials as Effective Carriers Targeted to Traverse Blood–Brain Barrier for Theragnostics of Neurodegenerative Diseases: An Overview

BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 21, 2024

Language: Английский

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Nanoparticles for Drug Delivery in Parkinson's Disease: A Review of Potential Applications

The Neuroscience Journal of Shefaye Khatam, Journal Year: 2024, Volume and Issue: 12(4), P. 67 - 80

Published: Oct. 1, 2024

Language: Английский

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Investigation of the interaction mechanism and enzyme activity of trypsin with cerium oxide nanoparticles

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 325, P. 125156 - 125156

Published: Sept. 17, 2024

Language: Английский

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Nanoparticle-mediated drug delivery for neurodegenerative diseases

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 267 - 307

Published: Nov. 29, 2024

Language: Английский

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