Is Camphor the Future in Supporting Therapy for Skin Infections?

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 715 - 715

Published: May 31, 2024

The aim of this review is to present the potential application camphor—a bicyclic monoterpene ketone—in prevention skin infections. Skin diseases represent a heterogeneous group disorders characterized by prolonged symptoms that significantly diminish quality life. They affect dermis, epidermis, and even subcutaneous tissue. very often have bacterial or fungal background. Therapy for dermatological difficult long-term. Therefore, it important find compound, preferably natural origin, (i) prevents initiation infection (ii) supports skin’s repair process. Based on its documented anti-inflammatory, antibacterial, antifungal, anti-acne, anesthetic, strengthening, warming properties, camphor can be used as preventative measure in infectious component medical cosmetic products. This work discusses structure physicochemical properties camphor, occurrence, methods obtaining from sources well through chemical synthesis. use industrial preparations also presented. Additionally, after detailed literature, metabolism interactions with other medicinal substances, antimicrobial against bacteria fungi involved are discussed regard their resistance.

Language: Английский

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Exploring the multifaceted bioactivities of Lavandula pinnata L. essential oil: promising pharmacological activities

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: April 8, 2024

Introduction: This study investigates the biological activities of Lavandula pinnata essential oil (LPEO), an endemic lavender species from Canary Islands, traditionally used in treating various ailments. Methods: LPEO was extracted by hydrodistillation and analyzed using GC-MS. Antioxidant activity assessed DPPH radical scavenging total antioxidant capacity assays. Antimicrobial evaluated disc diffusion, MIC, MBC, MFC determination against bacterial ( Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa ) fungal Candida glabrata, Rhodotorula glutinis, Aspergillus niger, Penicillium digitatum strains. Antidiabetic anti-gout potential were investigated through α-amylase, α-glucosidase, xanthine oxidase inhibition Antityrosinase determined a modified dopachrome method. Cytotoxicity MTT assay breast (MCF-7, MDA-MB-468), liver (HepG2), colon (HCT-15) cancer cells, normal cells (PBMCs). Results discussion: exhibits potent antiradical (IC50 = 148.33 ± 2.48 μg/mL) significant (TAC 171.56 2.34 μg AA/mg EO). It demonstrates notable antibacterial four strains with zones ranging 18.70 0.30 mm to 29.20 mm, along relatively low MIC MBC values. displays antifungal fungicidal effect at 1 mg/mL, surpassing positive control (cycloheximide), values indicating effect. substantial enzyme 26.48 0.90 μg/mL), comparable allopurinol, marked inhibitory effects on α-amylase 31.56 0.46 α-glucosidase 58.47 2.35 enzymes.The tyrosinase is inhibited 29.11 0.08 mg/mL). moderate cytotoxic breast, liver, toxicity towards (PBMC). greater selectivity than cisplatin for (MCF-7) but lower (HepG2) metastatic (MDA-MB-468) cells. These findings suggest as antioxidant, antimicrobial, anti-gout, antidiabetic, anticancer agent.

Language: Английский

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Exploring the Molecular Mechanisms and Therapeutic Potentials of Essential Oils: A Systems Biology Approach

Future Integrative Medicine, Journal Year: 2024, Volume and Issue: 3(2), P. 116 - 131

Published: May 15, 2024

Essential oils, known for their pleasant aromas, not only calm the mind and elevate mood but also captivate interest of researchers aiming to unveil vast potential. Various methodologies are employed explore diverse capabilities essential often yielding promising significant outcomes. This review aims elucidate molecular mechanisms oils at cellular level. It identifies multiple through which exhibit therapeutic effects across various systems. However, a comprehensive understanding fundamental still necessitates extensive research. In this review, we discuss underlying biological activities specifically antioxidant, antimicrobial, anticarcinogenic, anti-diabetic, anti-inflammatory properties.

Language: Английский

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Isolation of Arborescin from Artemisia absinthium L. and Study of Its Antioxidant and Antimicrobial Potential by Use of In Vitro and In Silico Approaches

Separations, Journal Year: 2024, Volume and Issue: 11(7), P. 209 - 209

Published: July 5, 2024

This study focused on developing an innovative, straightforward, and economical method utilizing a mixture of readily available solvents to extract arborescin (C2OH2OO8) crystals from Artemisia absinthium L. (A. absinthium). The structural elucidation characterization were conducted using suite techniques including IR spectroscopy, CNHSO elemental analysis, scanning electron microscopy energy dispersive X-ray spectroscopy (SEM-EDS), mass (MS). Density functional theory (DFT) calculations employed determine the molecular properties. Antioxidant activity was measured DPPH radical scavenging assay β-carotene bleaching test. Antimicrobial efficacy assessed against four bacterial strains three fungal strains. docking approach predict probable binding patterns affinities with specific target biomolecules. Employing array analytical techniques, examination isolated crystal A. absinthium. led its comprehensive elucidation. revealed presence distinctive groups, carbonyl group within γ-lactone epoxy group. analysis verified that contained only carbon, hydrogen, oxygen, finding corroborated by SEM-EDS consistent structure arborescin. Additionally, spectrometry confirmed identity compound as arborescin, ion m/z = 248. Quantum-Chemical Descriptors is resistant elementary decomposition under standard conditions. Although demonstrates relatively low antioxidant capacity, IC50 5.04 ± 0.12 mg/mL in assay, test found be 3.64%. Remarkably, effectively inhibits growth Staphylococcus aureus Listeria innocua at concentrations (MIC 166 µg/mL). it exhibits significant antifungal Candida glabrata, minimum inhibitory concentration (MIC) fungicidal (MFC) 83 µg/mL µg/mL, respectively. In this study, exhibited robust score −8.1 kcal/mol, indicating higher affinity compared ciprofloxacin. suggests has potential potent antibacterial agent.

Language: Английский

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Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines

Life, Journal Year: 2024, Volume and Issue: 14(8), P. 1037 - 1037

Published: Aug. 20, 2024

The objective of this study was to evaluate the antioxidant, anti-inflammatory, and anticancer properties thymol, carvacrol, their equimolar mixture. Antioxidant activities were assessed using DPPH, ABTS, ORAC methods. thymol/carvacrol mixture exhibited significant synergism, surpassing individual compounds ascorbic acid in DPPH (IC

Language: Английский

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Extraction of Bioactive Compound-Rich Essential Oil from Cistus ladanifer L. by Microwave-Assisted Hydrodistillation: GC-MS Characterization, In Vitro Pharmacological Activities, and Molecular Docking

Separations, Journal Year: 2024, Volume and Issue: 11(7), P. 199 - 199

Published: June 27, 2024

Cistus ladanifer L. is an aromatic and resinous perennial shrub commonly used in Moroccan folk medicine against a range of illnesses including skin problems, diabetes, diarrhea, inflammation. The current investigation aims to determine the bioactive compounds C. essential oil (CL-Eo) extracted by microwave-assisted hydrodistillation their biological properties using vitro molecular docking approaches. GC-MS analysis identified linderol (17.76%), gamma-terpinene (17.55%), borneol (13.78%) as main compounds. CL-Eo significantly inhibited α-amylase (IC50 = 0.41 ± 0.009 mg/mL), α-glucosidase 0.49 0.002 mg/mL) lipase 0.45 0.004 enzymes. Moreover, showed significant hemoglobin glycation well antioxidant capacity indicated DPPH, ABTS, Frap beta-carotene tests. antimicrobial evaluation disc-diffusion microdilution tests vitro. results that had antibacterial activity, particularly P. mirabilis (17.16 1.04 mm), moderate effects innocua (13.48 1.65 mm) E. coli (12.47 0.61 mm). In addition, it demonstrated potent antifungal activity albicans (18.01 0.91 tropicalis (16.45 0.32 MIC MBC provided confirmation exhibited growth inhibition. ranged from 0.25 8.0% v/v or MFC 16.0% Eo. tolerance level ratio bactericidal fungicidal tested microbial strains varying degrees. According these data, might be suggested promising candidate for drug development, specifically combating candidiasis diabetes.

Language: Английский

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Determination of chemical composition, antimicrobial activity and in silico investigation of the essential oil extracted from peels of Citrus medica (Jora Tenga) & Citrus jambhiri (Gol Nemu) grown in north eastern region of India

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: 6, P. 100139 - 100139

Published: Jan. 5, 2025

Language: Английский

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Optimization of the Antibacterial Activity of a Three-Component Essential Oil Mixture from Moroccan Thymus satureioides, Lavandula angustifolia, and Origanum majorana Using a Simplex–Centroid Design

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 57 - 57

Published: Jan. 7, 2025

The rise of antibiotic-resistant pathogens has become a global health crisis, necessitating the development alternative antimicrobial strategies. This study aimed to optimize antibacterial effects essential oils (EOs) from Thymus satureioides, Lavandula angustifolia, and Origanum majorana, enhancing their efficacy through optimized mixtures. utilized simplex-centroid design mixture ratios EOs for maximal antioxidant effectiveness. chemical profiles were analyzed using gas chromatography-mass spectrometry (GC-MS). activity was assessed against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa minimum inhibitory concentration (MIC) tests, while evaluated DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) assays. oil mixtures demonstrated potent activity, with MIC values 0.097% (v/v) E. 0.058% S. 0.250% P. aeruginosa. achieving these results included 76% T. 24% O. majorana varying proportions other strains. Additionally, L. angustifolia exhibited strongest IC50 84.36 µg/mL (DPPH), 139.61 (ABTS), surpassing both standard antioxidants like BHT ascorbic acid in assay. successfully demonstrates that can serve as effective natural agents. findings highlight novel approach enhance applications oils, suggesting potential use food preservation biopharmaceutical formulations. optimization strategy offers promising avenue combat antibiotic resistance safety products.

Language: Английский

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Chemical profile, biological potential, molecular docking, molecular dynamics, and ADMET approaches of essential oils from extracted endemic Prangos aricakensis leaf and stem

Fitoterapia, Journal Year: 2025, Volume and Issue: 181, P. 106391 - 106391

Published: Jan. 16, 2025

Language: Английский

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Tetraclinis articulata (Vahl) Mast., Mentha pulegium L., and Thymus zygis L. essential oils: Chemical composition, antioxidant and antifungal properties against postharvest fungal diseases of apple, and in vitro, in vivo, and in silico investigation

Open Chemistry, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 1, 2025

Graphical abstract

Language: Английский

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