Physiological Research, Journal Year: 2024, Volume and Issue: Suppl. 3, P. S655 - S669
Published: Dec. 31, 2024
The global COVID-19 pandemic, caused by SARS-CoV-2, has led to significant morbidity and mortality, with a profound impact on cardiovascular health. This review investigates the mechanisms of SARS-CoV-2's interaction cardiac tissue, particularly emphasizing role Spike protein ACE2 receptor in facilitating viral entry subsequent complications. We dissect structural features virus, its interactions host cell receptors, resulting pathophysiological changes heart. Highlighting broad organ tropism, especially effects cardiomyocytes via TMPRSS2, addresses how these exacerbate issues patients pre-existing conditions such as diabetes hypertension. Additionally, we assess both direct indirect virus-induced damage, including myocarditis, arrhythmias, long-term complications 'long COVID'. underscores complexity SARS-CoV-2’s heart, need for ongoing research fully understand
Language: Английский