Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 4, 2024

Abstract The serotonin 2 receptor (5HT2R) agonist psilocybin displays rapid and persistent therapeutic efficacy across neuropsychiatric disorders characterized by cognitive inflexibility. However, the impact of on patterns neural activity underlying sustained changes in behavioral flexibility has not been characterized. To test hypothesis that enhances altering cortical ensembles, we performed longitudinal single-cell calcium imaging retrosplenial cortex a five-day trace fear learning extinction assay. A single dose induced ensemble turnover between days while oppositely modulating fearand extinctionactive neurons. acute suppression fear-active neurons delayed recruitment extinction-active were predictive psilocybin-enhanced extinction. computational model revealed inhibition is sufficient to explain its effects later. These results align with our introduce new mechanism involving populations cortex.

Language: Английский

Is there something sexual in the ventral midline thalamus?

Brain Structure and Function, Journal Year: 2025, Volume and Issue: 230(1)

Published: Jan. 6, 2025

Language: Английский

Age and sex independently influence safety learning in mice

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115594 - 115594

Published: April 1, 2025

Language: Английский