Size-Dependent Pulmonary Toxicity and Whole-Body Distribution of Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

The ubiquitous presence of micro/nanoplastics (MP/NP) in the atmosphere has raised significant concerns about their potential health risks through inhalation, yet effects natural respiratory exposure remain underexplored. This study addresses this critical knowledge void by utilizing a whole-body inhalation system to investigate distribution, accumulation, and pulmonary toxicity polystyrene MP/NP (1.5 × 105 particles/m3) male ICR mice (n = 16/group). Fluorescently labeled revealed highest particle accumulation lungs, followed bloodstream spleen, with minimal detection brain. Unsurprisingly, 80 nm nanoplastics displayed greater intertissue transport efficiency than 1 μm microplastics. Chronic both microplastics disrupted oxidative balance exacerbated stress within extracellular environment lungs. impaired antioxidant defenses intra- metabolism led inflammation, apoptosis, fibrosis. Intriguingly, induced more severe smaller counterparts, promoting epithelial-mesenchymal transition These findings underscore need for nuanced understanding size-dependent toxicities inhalable plastic particles highlight posed airborne MP/NP.

Language: Английский

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Microplastic pollution: Critical analysis of global hotspots and their impact on health and ecosystems

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 381, P. 124995 - 124995

Published: April 7, 2025

Language: Английский

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Developing a feasible fast-track testing method for developmental neurotoxicity studies: alternative model for risk assessment of micro- and nanoplastics

Frontiers in Toxicology, Journal Year: 2025, Volume and Issue: 7

Published: April 15, 2025

Micro- and nanoplastics (MNPs) are widespread environmental pollutants that pose significant health risks. They originate from industrial processes, consumer products, degradation, inducing oxidative stress through cellular dysfunctions such as membrane interaction, internalization, mitochondrial damage, inflammation, metal ion leaching, impaired antioxidant defense. Despite increasing evidence of their toxicity—particularly developmental neurotoxicity (DNT) impairment—our understanding remains limited due to the high costs animal studies, which reduce overall size experimental data. This underscores urgent need for alternative test methods cost-effective, rapid, translational. review examines new approach methodologies (NAMs) DNT assessment, addressing ethical, financial, translational limitations models. NAMs integrate three complementary non-animal models enhance conventional testing. First, zebrafish provide organismal insights into behavioral neurodevelopmental outcomes at minimal cost. Second, neuronal organoids replicate human-specific processes in a 3D system, offering mechanistic insights. Lastly, human cell lines enable high-throughput screening, integrating findings organoid studies. Establishing paradigm testing is crucial faster more efficient toxicity risk assessments, ultimately protecting public health. Standardizing gaining regulatory acceptance will improve predictive accuracy broaden application toxicology. Advancing these essential risks MNP exposure while promoting ethical sustainable research practices.

Language: Английский

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Illusion of Incense Smoke and Associated Health Risk: An Investigation of Ocular and Respiratory Particulate Deposition

Archives of Environmental Contamination and Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

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Microplastic distribution and its implications for human health through marine environments

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 382, P. 125427 - 125427

Published: April 18, 2025

Language: Английский

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