Biology, Journal Year: 2024, Volume and Issue: 13(11), P. 885 - 885
Published: Oct. 30, 2024
In 2021, the World Health Organization classified isocitrate dehydrogenase (
Language: Английский
Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)
Published: July 5, 2024
Abstract The extracellular matrix (ECM) is a dynamic set of molecules produced by the cellular component normal and pathological tissues embryo adult. ECM acts as critical regulator in various biological processes such differentiation, cell proliferation, angiogenesis, immune control. most frequent primary brain tumors are gliomas far majority adult astrocytic (AATs). prognosis for patients with these neoplasms poor treatments modestly improves survival. In literature, there fair number studies concerning composition AATs, while relating regulation smaller. Circulating proteins have emerged promising biomarker that reflect general landscape tumor microenvironment may represent useful tool assessing disease activity. Given importance it can therapeutic prognostic purposes, aim our study to summarize properties components their effects on provide an overview interactions between major cells AATs. As field immunotherapy glioma quickly expanding, we retain current data together future organization functions will important insights into tuning immunotherapeutic approaches. Graphical
Language: Английский
Citations
4
Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 492 - 492
Published: Feb. 22, 2025
Freund’s adjuvants have been used in vaccine and autoimmune settings, their effects can be overlapping or unique to each. While both incomplete (IFA) complete (CFA) influence antibody T cell responses, the robust helper 1 cytokines induced by mycobacterial components make CFA powerful immunostimulating adjuvant. In these studies, adjuvant are investigated a select population of cells, changes, if any, with metabolic alterations systemic compartment unclear. We whether IFA influenced shifts mice immunized saline, IFA, using Mycobacterium tuberculosis var. bovis Bacillus Calmette–Guérin (BCG) as positive control. After seven days immunization, we analyzed serum metabolite profiles liquid chromatography coupled high-resolution mass spectrometry multivariate statistical analysis identify features between groups. The data revealed that, scores space, BCG groups were more closely aligned compared saline group, while group displayed an intermediate profile. Furthermore, comparisons showed significant perturbations lipid amino acid metabolism, particularly involving glycerophospholipids, cysteine, aromatic acids. contrast, indicated pronounced disruption central energy metabolism pathways, such citric cycle pyruvate metabolism. Together, suggest that response might play role modulating immune responses.
Language: Английский
Citations
0
Future Oncology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8
Published: March 3, 2025
Cholangiocarcinoma (CCA) is a rare and aggressive cancer with poor prognosis. Ivosidenib, an orally administered, first-in-class small-molecule inhibitor, targets the mutated isocitrate dehydrogenase 1 (IDH1) enzyme. Recently, ivosidenib has been approved for treating patients locally advanced or metastatic IDH1 R132-mutated CCA following at least one prior systemic therapy. The pivotal phase 3 ClarIDHy trial revealed that nearly doubled median progression-free survival significantly improved overall after adjusting crossover. However, prospective real-world data on remain limited. IDHIRA study prospective, multicenter, longitudinal, non-interventional conducted in Germany. will enroll 100 CCA, aiming to evaluate effectiveness, safety, quality of life (QoL) associated treatment patients.
Language: Английский
Citations
0
Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Journal Year: 2024, Volume and Issue: 32(6), P. 1037 - 1045
Published: Jan. 1, 2024
Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production 2-Hydroxyglutrate (2HG) may alter expression epigenetic proteins in Grade 4 astrocytoma.The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, protein proteins-5 (PRMT5) activity, with tumor progression has never been described.Methods: A retrospective cohort 34 patients G4 astrocytoma is classified into IDH-mutant IDH-wildtype tumors.Both groups were tested for MGMT-promoter methylation PRMT5 through methylation-specific gene PCR analysis.Inter-cohort statistical significance was evaluated.Results: Both WHO grade astrocytomas (n = 22, 64.7%) glioblastomas 12, 35.3%) had upregulated except one case.Out 22 tumors, 10 (45.5%) tumors showed 12 (54.5%)tumors unmethylated MGMT.All MGMT.There a statistically significant relationship IDH (p-value 0.006).Statistically differences progression-free survival (PFS) also observed among all that expressed received either temozolomide (TMZ) or TMZ plus other chemotherapies, regardless their MGMT-methylation status (p-value=0.0014).Specifically, activity who only TMZ, have exhibited longer PFS.Conclusions: PRMT5, MGMT-promoter, not tridirectional.However, accumulation D2-hydroxyglutarate (2-HG), which partially activates 2-OG-dependent deoxygenase, affect activities.In glioblastomas, 2HG-2OG pathway typically inactive, leading to upregulation.TMZ alone, compared TMZ-plus, can increase PFS tumors.Thus, using inhibitor help regression.
Language: Английский
Citations
1
Targeted Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 15, 2024
Language: Английский
Citations
1
Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107437 - 107437
Published: Sept. 30, 2024
Increasing evidence indicates that 2-hydroxyglutarate (2HG) is an oncometabolite drives tumour formation and progression. Due to mutations in isocitrate dehydrogenase (IDH) the dysregulation of other enzymes, 2HG accumulates significantly cells. its structural similarity α-ketoglutarate (αKG), accumulated leads competitive inhibition αKG-dependent dioxygenases (αKGDs), such as KDMs, TETs, EGLNs. This results epigenetic alterations both cells microenvironment. review comprehensively discusses metabolic pathways subsequent influenced by elevated levels. We will delve into molecular mechanisms which exerts oncogenic effects, particularly focusing on modifications. also explore various methods available for detection 2HG, emphasising current techniques emerging technologies. Furthermore, shows promise a biomarker clinical diagnosis treatment. By integrating these perspectives, this aims provide comprehensive overview understanding cancer biology, highlight importance ongoing research, discuss future directions translating findings applications.
Language: Английский
Citations
0
Biology, Journal Year: 2024, Volume and Issue: 13(11), P. 885 - 885
Published: Oct. 30, 2024
In 2021, the World Health Organization classified isocitrate dehydrogenase (
Language: Английский
Citations
0