International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125117 - 125117
Published: Dec. 1, 2024
Language: Английский
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 330 - 347
Published: Feb. 8, 2025
Language: Английский
Citations
2
Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 2050 - 2050
Published: April 29, 2024
Deferoxamine, an iron chelator used to treat diseases caused by excess iron, has had a Food and Drug Administration-approved status for many years. A large number of studies have confirmed that deferoxamine can reduce inflammatory response promote angiogenesis. Blood vessels play crucial role in sustaining vital life facilitating the delivery immune cells, oxygen, nutrients, as well eliminating waste products generated during cellular metabolism. Dysfunction blood may contribute significantly development life-threatening diseases. Anti-angiogenesis therapy pro-angiogenesis/angiogenesis strategies been frequently recommended various Herein, we describe mechanism which promotes angiogenesis summarize its application chronic wounds, bone repair, respiratory system. Furthermore, discuss drug system treating diseases, providing constructive ideas inspiration new treatment strategies.
Language: Английский
Citations
9
Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 562 - 562
Published: Feb. 24, 2025
Background/Objectives. Chronic wounds pose a substantial global healthcare burden exacerbated by aging populations and the increasing prevalence of conditions such as diabetes, peripheral vascular disease, venous insufficiency. Impaired physiological repair mechanisms, including angiogenesis, collagen synthesis, re-epithelialization, hinder healing process in chronic wounds. Many these processes are dependent on their interaction with copper. We hypothesized that targeted delivery copper ions to wound bed would enhance healing. Methods. Wound dressings impregnated oxide microparticles were designed ensure controlled release ions. The efficacy was evaluated using non-infected models, diabetic mouse models compared against control silver dressings. Outcome measures included closure rates, epidermal skin quality assessed histopathological examination, gene expression profiling. Clinical applications through diverse case studies trials involving management. Results. Copper significantly accelerated enhanced angiogenesis Histopathological analyses revealed faster granulation tissue formation, regeneration, neovascularization. Gene showed upregulation critical angiogenic factors VEGF HIF-1α. Investigations clinical observations corroborated improved across various types, Conclusions. is essential for healing, copper-impregnated provide promising solution By enhancing go beyond antimicrobial action, offering cost-effective innovative alternative conventional therapies. represent transformative advancement addressing challenges care.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 21, 2025
Cutaneous leishmaniasis (CL) contributes significantly to the global burden of neglected tropical diseases, with 12 million people currently infected Leishmania parasites. CL encompasses a range disease manifestations, from self-healing skin lesions permanent disfigurations. Currently there is no vaccine available, and many patients are refractory treatment, emphasizing need for new therapeutic targets. Previous work demonstrated macrophage HIF-α-mediated lymphangiogenesis necessary achieve efficient wound resolution during murine L. major infection. Here, we investigate role HIF-α signaling independent lymphangiogenesis. We sought determine relative contributions parasite host-mediated inflammation in lesional microenvironment myeloid signaling. Because activation can be detected bystander macrophages leishmanial lesions, hypothesize it host’s inflammatory response microenvironment, rather than parasite, that triggers activation. To address this, mice intact (LysM Cre ARNT f/+ ) or deleted f/f were subjected RNASequencing after infection under pro-inflammatory stimulus. report alone enough induce some minor HIF-α-dependent transcriptomic changes, while combination stimuli induces numerous changes both dependent Additionally, by coupling analysis several pathway analyses, found suppresses pathways involved protein translation environment. Together these findings show program, but only Thus, this indicates host response, largely
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114575 - 114575
Published: April 10, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: April 9, 2025
A traditional preparation of Ya-Samarn-Phlae (T-YaSP) consists Garcinia mangostana L., Oryza sativa Curcuma longa and Areca catechu L. has been used in Thai medicine as an infused oil for treating chronic diabetic wounds. It is reputed its antibacterial, antioxidant, wound-healing properties. Despite use, scientific validation the mechanisms underlying wound healing remains limited. This study aims to develop a novel gauze dressing impregnated with ointment containing T-YaSP (YaSP) enhance practical application elucidate action promoting both non-diabetic type 2 wounds this ointment. YaSP was developed tested stability dermal irritation. Changes chemical markers during storage were measured qualitatively quantitatively. Its anti-inflammatory activity assessed using carrageenan-induced rat paw edema model. The effect on levels nitric oxide (NO), myeloperoxidase (MPO), malondialdehyde (MDA), inflammatory cytokines (TNF-α, IL-1β, PGE2), pro-inflammatory enzymes (iNOS COX-2) measured. effects full-thickness (6 mm diameter) models Wistar rats Goto-Kakizaki rats. In addition evaluating closure days 0, 3, 5, 7, 9, 11, influence TGF-β1, VEGF, production collagen types I III, which indicate inflammatory, proliferative, remodeling phases, During 6-month period, α-mangostin content did not decrease; however, curcumin level showed significant reduction. Topical treatment demonstrated strong alleviated oxidative stress markers. improved rates models. Levels TGF-β1 VEGF increased, indicating promotion angiogenesis granulation tissue formation proliferation phase seventh day. Additionally, dropped 11th day, aligning diminished inflammation enhanced remodeling. balanced synthesis, increasing III early stages later healing. Histological analysis confirmed reduced inflammation, neovascularization, increased production. provides solution management demonstrates properties by modulating excess phase, regulating synthesis throughout phase. discovery reveals, first time, formulation, highlighting potential cost-effective alternative managing resource-limited settings.
Language: Английский
Citations
0
Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Diabetic ulcers, affecting 15-25% of diabetes patients worldwide, are characterized by localized hypoxia that impedes healing. This review explores the emerging field in situ oxygen-generating nanozymes as a promising approach to diabetic ulcer treatment. Nanozymes, synthetic nanoparticles mimicking natural enzyme activities, have shown potential generating oxygen situ, scavenging reactive species, and modulating wound microenvironment. Materials such manganese dioxide, cerium platinum nanoparticles, molybdenum-based quantum dots demonstrated efficacy preclinical studies, often exhibiting multiple enzyme-like activities. These accelerated closure, enhanced angiogenesis, improved tissue regeneration animal models. However, challenges remain, including optimizing nanozyme-hydrogel interactions, addressing toxicity metal-based nanomaterials, determining optimal concentrations for various conditions. Future research directions include developing biocompatible nanozymes, enhancing delivery systems, exploring combination therapies. underscores nanozyme-based therapies revolutionize treatment ulcers potentially other hypoxia-related
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144407 - 144407
Published: May 1, 2025
Language: Английский
Citations
0
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(7), P. 4195 - 4226
Published: May 16, 2024
Diabetic foot ulcers (DFU) are chronic, refractory wounds caused by diabetic neuropathy, vascular disease, and bacterial infection, have become one of the most serious persistent complications diabetes mellitus because their high incidence difficulty in healing. Its malignancy results from a complex microenvironment that includes series unfriendly physiological states secondary to hyperglycemia, such as recurrent infections, excessive oxidative stress, inflammation, ischemia hypoxia. However, current common clinical treatments, antibiotic therapy, insulin surgical debridement, conventional wound dressings all drawbacks, suboptimal outcomes exacerbate financial physical burdens patients. Therefore, development new, effective affordable treatments for DFU represents top priority improve quality life In recent years, nanozymes-based therapy systems been attracting extensive interest integrating unique advantages nanomaterials natural enzymes. Compared with enzymes, nanozymes possess more stable catalytic activity, lower production cost greater maneuverability. Remarkably, many multienzyme activities can cascade multiple enzyme-catalyzed reactions simultaneously throughout recovery process DFU. Additionally, favorable photothermal-acoustic properties be exploited further enhancement therapeutic effects. this review we first describe characteristic pathological DFU, then discuss mechanisms applications healing, finally, highlight challenges perspectives nanozyme treatment.
Language: Английский
Citations
1
Trends in Immunotherapy, Journal Year: 2024, Volume and Issue: 8(2), P. 4186 - 4186
Published: July 24, 2024
Diabetes mellitus (DM) is characterized by hyperglycemia, which a common endocrine disease. DM and its complications may lead to diabetic foot ulcers (DFU). DFU associated with reduced wound healing because of altered cellular cytokine responses, inadequate vascularization, infection, neuropathy. One novel promising approach treating the administration compounds based on nanotherapeutics, such as nanoparticles nanoscaffolds. Plant extracts can be administered more successfully using nanoscale delivery methods. their related phytocompounds nanostructured enhance bioavailability, regulate release via extended techniques site, increase penetration deeper layers skin. All these benefits are critical for process. This brief overview covers most recent methods develop phytomedicine nanotherapeutics treatment wounds.
Language: Английский
Citations
1