Exploring the innovative application of cerium oxide nanoparticles for addressing oxidative stress in ovarian tissue regeneration DOI Creative Commons

Maya Lakshmanan,

Monika Saini, Manasa Nune

et al.

Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 5, 2024

Abstract The female reproductive system dysfunction considerably affects the overall health of women and children on a global scale. Over decade, incidence disorders has become significant source suffering for women. Infertility in may be caused by range acquired congenital abnormalities. Ovaries play central role function. Any defect normal functioning these endocrine organs causes issues challenges extending beyond infertility, as hormones interact with other tissues biological processes body. complex pathophysiology ovarian makes it multifactorial disease. key etiological factors associated diseases include genetic factors, hormonal imbalance, environmental lifestyle inflammatory conditions, oxidative stress, autoimmune diseases, metabolic age. Oxidative stress is major contributor to disease development progression affecting oocyte quality, fertilization, embryo development, implantation. choice treatment varies among individuals complications. Reproductive tissue engineering holds great promise overcoming current therapeutic approach regeneration. Furthermore, incorporating nanotechnology into could offer an efficient strategy. This review provides overview antioxidant nanomaterials address recurrence pathophysiology. Cerium oxide nanoparticles (CeO 2 NPs) are prioritized evaluation primarily due their properties. In conclusion, explores potential applications CeO NPs effective clinically Graphical

Language: Английский

Biosynthesis and health promoting traits of green synthesized cobalt oxide nanoparticles DOI Creative Commons
Raghda M.S. Moawad, Yasmine Abdallah, Mohamed Mohany

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 3, 2025

Nanomedical applications have increased significantly. This work aimed to fabricate and characterize cobalt oxide nanoparticles (CoOnps) synthesized biologically via aqueous Alhagi maurorum extract evaluate their cytotoxic antimicrobial impacts. Green-synthesized CoOnps were prepared analyzed using UV–Vis spectrophotometer UV–vis, Scanning electron microscopy (SEM), Transmission TEM, Energy dispersive X-ray analysis EDAX, Fourier transform infrared, FTIR, diffraction (XRD). In vitro traits of green-synthesized studied on ovarian cancer cells (SKOV3) a Sulforhodamine B (SRB) method. The effect IC50 estimated. Moreover, concentrations 10, 30, 40, 70, 100, 200, 300, 400 500 μg/mL applied investigate against Listeria, Staphylococcus aureus Streptococcus as gram +ve pathogenic bacteria, Bifidobacterium bifidum 2203, LMG 10,645, breve LMC 017, angulatum 2238 longum ATCC 15,707 probiotics, E. coli −ve bacterial model yeast strain Candida albicans. showed anti-ovarian effects at 24.02 μg/mL. Furthermore, it exerted activity versus Streptococcus, S. aureus, 31.66 ± 0.88, 24.33 2.08, 25.66 0.33, 33.00 6.08; however, they did not suppress the growth albicans all tested Bifidobacterial strains up with significant difference compared p < 0.05. Green synthesis is low-cost, eco-friendly easily Its impressive features SKOV3, cell line antibacterial for some besides maintaining could candidate them competitive agents medical, pharmacological, agricultural food applications.

Language: Английский

Citations

2
Targeting autophagy in premature ovarian failure: Therapeutic strategies from molecular pathways to clinical applications DOI

Ziwen Ding,

Genbao Shao, Mingyang Li

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123473 - 123473

Published: Feb. 1, 2025

Language: Английский

Citations

1
A Short-Chain Analogue of Seminolipid: Synthesis and Inhibitory Effect on Mouse Fertilization DOI Creative Commons
Seung Gee Lee,

Leila Vahdati,

Laura Morelli

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 611 - 611

Published: April 23, 2025

Background/Objectives: Seminolipid (sulfogalactosylglycerolipid (SGG)) is abundantly present on the sperm surface and its roles in sperm–egg interaction are well-documented. SGG liposomes have direct affinity for zona pellucida (ZP), egg extracellular matrix. also integral to formation of lipid rafts, which platforms ZP binding. Our objective was chemically synthesize a short-chain analog (SC-SGG with C6 acyl chain instead C16 natural lipid), solubilized an aqueous environment, determine inhibitory effects SC-SGG mouse interaction, thus fertilization. Methods: synthesized from 3-O-galactopyranosyl-sn-glycerol intermediate protected sugar moiety through acylation glycerol caproic acid, deprotection regioselective 3-O-sulfation galactose residue. medium used treat co-incubates or pretreat eggs before co-incubating vice versa. Sperm–ZP binding fertilization (scoring two pronuclei) were microscopically assessed. Results: efficiently 78% overall yield. inhibited sperm–ZP gametes concentration-dependent manner, at 6 µM SC-SGG, zero. fertilizing ability both eggs, as shown pretreatment experiments. Conclusions: effective inhibitor vitro. It warrants development be non-hormonal contraceptive.

Language: Английский

Citations

0
Contrast-Enhanced Ultrasonography combined with Microbubbles for uterine disorders: current trends and future perspectives DOI Creative Commons

Jian Ding,

Wenhai Wang, Wenbin Zhang

et al.

SLAS TECHNOLOGY, Journal Year: 2025, Volume and Issue: unknown, P. 100301 - 100301

Published: May 1, 2025

Language: Английский

Citations

0
Impacts of designed vanillic acid-polymer-magnetic iron oxide nanocomposite on breast cancer cells DOI Creative Commons
Farahnaz Barahuie, Dena Dorniani, Bullo Saifullah

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32863 - e32863

Published: June 1, 2024

The engineered nano-vehicle was constructed using magnetic iron oxide nanoparticles (MIONs) and chitosan (CTS) to stabilize anticancer agent vanillic acid (VNA) which loaded on CTS-coated MIONs nanocarrier, more importantly, achieve sustained VNA release subsequent proper activity. new thermally stable VNA-CTS- nanocomposite spherical with a middle diameter of 6 nm had high drug loading about 11.8 %. resulting were composed pure magnetite therefore, superparamagnetic saturation magnetizations 53.3 45.7 emu.g−1, respectively. profiles from VNA-CTS-MIONs in different pH values showed controlled pH-responsive delivery the 89 % 74 percentage within 2354 4046 min at 5 7.4, respectively, as well accordance pseudo-second-order model. treatment diverse concentrations remarkably decreased viability promoted ROS accumulation apoptosis MDA-MB-231 breast cancer cells. Hence, it can be propitious candidate for management future.

Language: Английский

Citations

3
Nanoparticle-Based Interventions for Polycystic Ovary Syndrome: A Review of Mechanisms and Therapeutic Potential DOI

Dhanyaa Muthukumaran,

Rajeshkumar Shanmugam

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106348 - 106348

Published: Nov. 1, 2024

Language: Английский

Citations

2
The Application of Nano Drug Delivery Systems in Female Upper Genital Tract Disorders DOI Creative Commons
Daniélle van Staden, Minja Gerber, Hendrik J. R. Lemmer

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1475 - 1475

Published: Nov. 19, 2024

The prevalence of female reproductive system disorders is increasing, especially among women age, significantly impacting their quality life and overall health. Managing these diseases effectively challenging due to the complex nature system, characterized by dynamic physiological environments intricate anatomical structures. Innovative drug delivery approaches are necessary facilitate precise regulation manipulation biological tissues. Nanotechnology increasingly considered manage disorders, for example, nanomaterial imaging allows early detection enhances diagnostic precision determine disease severity progression. Additionally, nano systems gaining attention ability target successfully, thereby increasing therapeutic efficacy decreasing side effects. This comprehensive review outlines anatomy upper genital tract highlighting mucosal barriers impact on systemic local delivery. Advances in described sustainable action increased biocompatibility highlight potential strategies managing disorders.

Language: Английский

Citations

1
Advancements in siRNA delivery using nanotechnology for reproductive tract cancers: From targeting to enhancing treatment efficacy DOI

Krishna Kant Jangde,

Dinesh Kumar Mishra

Journal of Reproductive Healthcare and Medicine, Journal Year: 2024, Volume and Issue: 5, P. 6 - 6

Published: Aug. 5, 2024

Cancers of the reproductive system, which include those cervix, uterus, ovaries, fallopian tubes, and vagina, are major global health concerns. Even with improvements in traditional therapies such as radiation chemotherapy, managing these tumors is still difficult, frequently associated side effects, has limited effectiveness. Targeted cancer therapy now better options, thanks to development small interfering ribonucleic acid (siRNA) a potentially effective therapeutic procedure through interference (RNAi) technique recent years. Nevertheless, there many challenges clinical translation siRNA, especially terms delivering drugs effectively tumor-specific areas while reducing off-target effects. Nanotechnology emerged transformative perspective that could show promising approach for providing revolutionary solution problems related siRNA delivery. By carefully crafting nanocarriers, including liposomes, polymeric nanoparticles, lipid scientists have made incredible strides toward improving bioavailability, stability, efficacy, selectivity treatments. Furthermore, due their customizable characteristics, nanocarriers be used target specific tract, enhancing effectiveness treatment by taking advantage indicators microenvironments. In this review, we will summarize delve into leveraging synergistic benefits targeted delivery enhanced potency using RNAi technique. These innovative strategies hold immense potential reshape landscape, offering new hope patients devastating tract malignancies.

Language: Английский

Citations

0
Electrospun zinc oxide nanoscaffolds: a targeted and selective anticancer approach DOI
Zafar Said, Haitham S. Mohammed, Sara Ibrahim

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 22

Published: Nov. 7, 2024

This study aims to prepare, characterize, and evaluate zinc oxide nanoscaffolds (ZnO NSs) as a potential anticancer drug that selectively targets malignant cells while remaining non-toxic normal cells. Electrospun NSs were fabricated loaded with varying concentrations of ZnO nanoparticles (NPs). The uniform morphology the samples was confirmed through Field Emission Scanning Electron Microscope (FESEM) imaging. Elemental composition investigated using Energy Dispersive X-ray spectroscopy (EDX), Fourier Transform Infrared (FTIR), diffraction (XRD) analyses. Biocompatibility cytotoxicity assessed (3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay) (MTT) assay flow cytometry. water uptake degradation properties electrospun also examined. Furthermore, cumulative release profile generated assess behavior NSs. prepared demonstrated negligible toxicity toward human dermal Conversely, four used displayed substantial induced apoptosis in various cancer cell lines. observed effects concentration-dependent. Notably, 8% exhibited most significant reduction viability against MCF7 line. findings from this indicate an effective agent, demonstrating pronounced impact. research introduces novel application nanoscaffolds, their capacity for selective activity, particularly breast carcinoma, preserving viability. presents advancement use nanomaterial targeted therapy.

Language: Английский

Citations

0
Exploring the innovative application of cerium oxide nanoparticles for addressing oxidative stress in ovarian tissue regeneration DOI Creative Commons

Maya Lakshmanan,

Monika Saini, Manasa Nune

et al.

Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 5, 2024

Abstract The female reproductive system dysfunction considerably affects the overall health of women and children on a global scale. Over decade, incidence disorders has become significant source suffering for women. Infertility in may be caused by range acquired congenital abnormalities. Ovaries play central role function. Any defect normal functioning these endocrine organs causes issues challenges extending beyond infertility, as hormones interact with other tissues biological processes body. complex pathophysiology ovarian makes it multifactorial disease. key etiological factors associated diseases include genetic factors, hormonal imbalance, environmental lifestyle inflammatory conditions, oxidative stress, autoimmune diseases, metabolic age. Oxidative stress is major contributor to disease development progression affecting oocyte quality, fertilization, embryo development, implantation. choice treatment varies among individuals complications. Reproductive tissue engineering holds great promise overcoming current therapeutic approach regeneration. Furthermore, incorporating nanotechnology into could offer an efficient strategy. This review provides overview antioxidant nanomaterials address recurrence pathophysiology. Cerium oxide nanoparticles (CeO 2 NPs) are prioritized evaluation primarily due their properties. In conclusion, explores potential applications CeO NPs effective clinically Graphical

Language: Английский

Citations

0