Different Forms of Regulated Cell Death in Type-2-Diabetes-Mellitus-Related Osteoporosis: A Focus on Mechanisms and Therapeutic Strategies

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4417 - 4417

Published: May 6, 2025

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with high prevalence and challenging treatment options. It significantly affects the function of various organs, including bones, imposes substantial social economic costs. Chronic hyperglycemia, insulin resistance, abnormalities in glucolipid metabolism can lead to cellular damage within body. Bone dysfunction represents significant characteristic diabetic osteoporosis (DOP). Recent studies confirm that cell death critical factor contributing bone damage. Regulated (RCD) highly controlled process involves numerous proteins specific signaling cascades. RCD processes, apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, cuproptosis, may be linked cells T2DM. In this review, types populations during pathogenic DOP were explored, link between processes pathogenesis was further explored. addition, research progress on targeting for summarized paper. This provide foundation additional explorations drug development, as well new therapeutic concepts clinical management DOP.

Language: Английский

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Decoding Osteoporosis: Understanding the Disease, Exploring Current and New Therapies and Emerging Targets.

Journal of Orthopaedic Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100472 - 100472

Published: Sept. 1, 2024

Language: Английский

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Could cuproptosis be a novel therapeutic target for tooth eruption disturbances

Medical Hypotheses, Journal Year: 2024, Volume and Issue: 188, P. 111378 - 111378

Published: May 14, 2024

Language: Английский

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