Bioinformatics analysis of an immunotherapy responsiveness- related gene signature in predicting lung adenocarcinoma prognosis DOI Open Access
Yupeng Jiang,

Bacha Hammad,

Hong Huang

et al.

Translational Lung Cancer Research, Journal Year: 2024, Volume and Issue: 13(6), P. 1277 - 1295

Published: June 1, 2024

Immune therapy has become first-line treatment option for patients with lung cancer, but some respond poorly to immune therapy, especially among adenocarcinoma (LUAD). Novel tools are needed screen potential responders in LUAD patients, better predict the prognosis and guide clinical decision-making. Although many efforts have been made responsiveness of results were limited. During era immunotherapy, this study attempts construct a novel prognostic model by utilizing differentially expressed genes (DEGs) differential responses.

Language: Английский

Lactylation: The Metabolic Accomplice Shaping Cancer's Response to Radiotherapy and Immunotherapy DOI
Danqing Yu, Qingping Zhong, Yanlin Wang

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102670 - 102670

Published: Jan. 1, 2025

Language: Английский

Citations

1
Unveiling lactylation modification: A new hope for cancer treatment DOI Open Access

Yuxiang Luo,

Ning Zhang, Jiarong Ye

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117934 - 117934

Published: Feb. 21, 2025

Language: Английский

Citations

1
The role of lactylation in tumor growth and cancer progression DOI Creative Commons

Khulood Al-Malsi,

Sinan Xie, Yunshi Cai

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 4, 2025

Background Lactate’s perception of lactate has changed over the last 30 years from a straightforward metabolic byproduct to complex chemical with important biological activities, such as signal transduction, gluconeogenesis, and mitochondrial respiration. In addition its contributions, far-reaching repercussions. This review highlights role in course cancer by highlighting lactylation unique epigenetic alteration. The purpose this is clarify functions biology tumors, particular focus on translational potential pathways diagnosis treatment approaches. Methods summarizes research relationship between cancer, an emphasis histone lactylation, effect gene expression, influence tumor microenvironment. By establishing connection byproducts regulation, we investigated how affects immune inflammation, cellular repair. Findings Histone or lysine residues proteins, increases transcriptional activity facilitates expression genes involved homeostasis These findings have implications for treatment. Lactylation, example, activates Arg1, which hallmark M2 macrophage phenotype implicated immunosuppression growth. ability dynamically alter further supported function deacetylase(HDAC)inhibitor impact acetylation. Its wide-ranging involvement metabolism control been demonstrated discovery sites histones various cell types, including cells.

Language: Английский

Citations

0
Establishment of a Lactylation‐Related Gene Signature for Hepatocellular Carcinoma Applying Bulk and Single‐Cell RNA Sequencing Analysis DOI Creative Commons
Lianghe Yu,

Yan Shi,

Zhengzhuo Zhi

et al.

International Journal of Genomics, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Lactylation is closely involved in cancer progression, but its role hepatocellular carcinoma (HCC) unclear. The present work set out to develop a lactylation-related gene (LRG) signature for HCC. Methods: lactylation score of tumor and normal groups was calculated using the variation analysis (GSVA) package. single-cell RNA sequencing (scRNA-seq) HCC performed "Seurat" Prognostic LRGs were selected by performing univariate least absolute shrinkage selection operator (LASSO) Cox regression analyses validate Riskscore model. Functional enrichment conducted (GSEA) "clusterProfiler" Genomic characteristics between different risk compared, mutational burden (TMB) "Maftools" Immune cell infiltration assessed algorithms cell-type identification estimating relative subsets transcript (CIBERSORT), microenvironment populations-counter (MCP-counter), proportions immune cells (EPIC), estimation resource (TIMER), single-sample (ssGSEA). Immunotherapy response predicted dysfunction exclusion (TIDE) algorithm. Drug sensitivity analyzed "pRRophetic" A nomogram established "rms" expressions prognostic verified vitro test, counting kit-8 (CCK-8), wound healing, transwell assays carried measure viability, migration, invasion cells. Results: score, which higher group than group, has been confirmed as an independent factor evaluation Six LRGs, including two protective genes (FTCD APCS) four (LGALS3, C1orf43, TALDO1, CCT5), identified model with strong prediction performance scRNA-seq revealed that LGALS3 largely expressed myeloid cells, while APCS, FTCD, CCT5, C1orf43 mainly hepatocytes. high-risk primarily enriched pathways occurrence development, T infiltration. Moreover, found be less responsive immunotherapy more sensitive chemotherapeutic drugs. By integrating clinical features, high predictive accuracy developed. Additionally, highly Silencing CCT5 inhibited Conclusion: developed novel LRG could considered promising therapeutic target biomarker

Language: Английский

Citations

0
Lactylation modification in cancer: mechanisms, functions, and therapeutic strategies DOI Creative Commons
Mengqi Lv,

Yefei Huang,

Yansu Chen

et al.

Experimental Hematology and Oncology, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 8, 2025

Cancer remains the leading cause of mortality worldwide, and emergence drug resistance has made identification new therapeutic targets imperative. Lactate, traditionally viewed as a byproduct glycolysis with limited ATP-producing capacity, recently gained recognition critical signaling molecule. It plays key role not only in cancer cell metabolism but also shaping tumor microenvironment (TME). Histone lysine lactylation, newly identified post-translational modification, been shown to influence range cellular processes cancer. Current research focuses on mechanisms functions histone lactylation cancer, including its gene expression regulation, signal transduction, protein synthesis. However, despite these advancements, there are still plenty barriers quest unravel modification. The single-cell spatial transcriptomics may offer valuable insights for selecting targets. This review provides comprehensive summary applications modification clinical settings. Through detailed analysis, we identify challenges limitations that exist current landscape. These lay groundwork future studies by highlighting promising directions.

Language: Английский

Citations

0
Research progress on the regulatory role of lactate and lactylation in tumor microenvironment DOI
Chunyan Gao,

Jiali Li,

Baoen Shan

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189339 - 189339

Published: April 1, 2025

Language: Английский

Citations

0
Lactylation as a metabolic epigenetic modification: Mechanistic insights and regulatory pathways from cells to organs and diseases DOI
Cong Chen, Jie Wang, Xueying Zhu

et al.

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156289 - 156289

Published: May 1, 2025

Language: Английский

Citations

0
New insights into the roles of lactylation in cancer DOI Creative Commons

Yajun Emily Zhu,

Wenhui Liu, Zhiying Luo

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 22, 2024

Lactylation, a novel discovered posttranslational modification, is vital component of lactate function and prevalent in wide range cells, interacting with both histone non-histone proteins. Recent studies have confirmed that lactylation as new contributor to epigenetic landscape involved multiple pathological processes. Accumulating evidence reveals exists different pathophysiological states leads inflammation cancer; however, few mechanisms been elaborated. This review summarizes the biological processes roles cancer, well discusses relevant potential therapeutic targets, aiming provide insights for targeted cancer therapy.

Language: Английский

Citations

3
Bioinformatics analysis of an immunotherapy responsiveness- related gene signature in predicting lung adenocarcinoma prognosis DOI Open Access
Yupeng Jiang,

Bacha Hammad,

Hong Huang

et al.

Translational Lung Cancer Research, Journal Year: 2024, Volume and Issue: 13(6), P. 1277 - 1295

Published: June 1, 2024

Immune therapy has become first-line treatment option for patients with lung cancer, but some respond poorly to immune therapy, especially among adenocarcinoma (LUAD). Novel tools are needed screen potential responders in LUAD patients, better predict the prognosis and guide clinical decision-making. Although many efforts have been made responsiveness of results were limited. During era immunotherapy, this study attempts construct a novel prognostic model by utilizing differentially expressed genes (DEGs) differential responses.

Language: Английский

Citations

2