Antidiabetic Potential of Abelmoschus manihot Flower Extract: In Vitro and Intracellular Studies DOI Creative Commons

Shih‐Wei Wang,

Thung‐Lip Lee,

Tzu-Hsien Chang

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(8), P. 1211 - 1211

Published: July 26, 2024

(L.) Medic flower (AMf) exhibits both nutritional value and bioactivities such as antioxidative, anti-inflammatory, neuroprotective, cardioprotective, hepatoprotective effects. The aim of this investigation was to examine the potential impact three different solvent extracts AMf: supercritical CO

Language: Английский

Prodigiosin As N-heterocyclic compound: Production Optimization, Bioactivity Evaluation, and In-Silico Docking Against Key Enzymes Related to Inflammation, Obesity, Diabetes, and the Insulin Signaling Pathway DOI
Walaa I. El-Sofany,

Tahani D Alanezi,

Salman Latif

et al.

Enzyme and Microbial Technology, Journal Year: 2025, Volume and Issue: unknown, P. 110639 - 110639

Published: March 1, 2025

Language: Английский

Citations

0
Heterocyclic Betanin from Opuntia stricta var. Dillenii: Purification, Stability, and Effects on Carbohydrate Digestion, Absorption, Metabolism, and Enzyme Inhibition in Obese Rats with Type 2 Diabetes DOI
Walaa I. El-Sofany, Ahmed S. Alshammari,

Mona Zaheed Alshammari

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106569 - 106569

Published: April 1, 2025

Language: Английский

Citations

0
Quercetin as a therapeutic agent for acute pancreatitis: a comprehensive review of antioxidant, anti-inflammatory, and immunomodulatory mechanisms DOI Creative Commons
Zhigang Jiang,

Gamar Lhamo,

Min Ma

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Acute pancreatitis (AP) is a severe inflammatory disorder of the pancreas, characterized by high morbidity and mortality rates. Despite significant advancements in understanding pathophysiological mechanisms AP, current treatment options still face considerable limitations. Recent studies have underscored therapeutic potential quercetin, natural flavonoid, due to its potent antioxidant, anti-inflammatory, immunomodulatory properties, positioning it as promising candidate for AP. This review explores effects quercetin on highlighting antioxidant activities, role immune modulation, protective pancreatic tissue. Furthermore, examines quercetin's multi-target advantages over conventional therapies, such N-acetylcysteine corticosteroids. Although preliminary suggest that can alleviate inflammation oxidative stress clinical evidence remains limited. One main challenges application low bioavailability. Future research should focus strategies enhance bioavailability conducting large-scale randomized controlled trials more comprehensively assess efficacy safety

Language: Английский

Citations

0
Protective Effects of Isolated Curcumin From Curcuma longa on Key Enzymes Involved in the Insulin Signaling Pathway and Digestive and Metabolic Enzymes Associated With Obesity, Type 2 Diabetes, and Hypertension DOI Creative Commons
Munirah Sulaiman Othman Alhar, Walaa I. El-Sofany, Ayshah Aysh ALrashidi

et al.

Journal of Diabetes Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

This study explores the potential of curcumin (CUR), extracted from Curcuma longa , in combating obesity and Type 2 diabetes. Obesity diabetes were induced rats through a high‐fat high‐fructose diet (HFFD), CUR, after purification characterization by Fourier transform infrared spectroscopy (FTIR) ultraviolet (UV) spectroscopy, was administered for 3 months via gastric gavage. The results show that CUR supplementation activates insulin signaling pathway dose‐dependent manner, leading to improved sensitivity. Specifically, administering at daily dose 100 mg/kg significantly reduces activities protein tyrosine phosphatase (PTP1B) dipeptidyl peptidase‐4 (DPP‐4) 43% 45%, respectively, obese diabetic compared untreated rats. Furthermore, effectively inhibits lipase α ‐amylase both serum intestinal levels. In rats, administration glycogen phosphorylase (GP) activity 35% enhances synthase (GS) 78%, substantial increase hepatic content. Additionally, also led 21% reduction food intake 12% decrease water consumption. These changes contributed significant reductions blood sugar glycosylated hemoglobin (HbA1c) levels, with decreases 59% 53%, respectively. body weight reduced thiobarbituric acid reactive substances (TBARSs), hydrogen peroxide (H O ), total oxidant status (TOS) 49%, 59%, 58%, demonstrates strong regulatory effect on levels low‐density lipoprotein cholesterol (LDL‐C), high‐density (HDL‐C), (TC). Overall, these underscore treating preventing obesity.

Language: Английский

Citations

0
Oral administration of proniosomal glibenclamide formulation protects testicular tissue from hyperglycemia fluctuations and ROS via Nrf2/HO-1 pathway DOI Creative Commons
Nouf M. Alyami,

Zainab A. Alnakhli,

Noura M. Alshiban

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e31283 - e31283

Published: May 1, 2024

Type 2 diabetes causes high blood sugar due to insulin malfunction and is linked male infertility. Using proniosomes can enhance the effectiveness of Glibenclamide, a medication that stimulates secretion. In our study, rats with were treated GLB or without proniosomal for 14 days. Proniosomal formulations maintained glucose levels prevented weight loss showed normal testicular tissue.GLB-proniosomal reduces ROS caused by T2DM through Nrf2, HO-1 pathway increases CAT, SOD, GSH production in response uptake. The reference treatments CAT SOD significant enzymatic elevation compared positive negative control. significantly correlated Gpx4 expression P = 0.0169 r 0.98; similarly, activity also correlation between average (r 0.99 0.0037). Intestinally, analysis revealed only proniosomal-GLB samples are elevated from control, value 0.0210. data was more effective than pure GLB, confirmed higher Nrf2 (2.050 folds), (2.148 GPx4 (1.9 folds) transcript relative control less sample diversity samples, indicating stabilized blood.Administering formulation has effectively restored function sperm diabetic regulating upregulating anti-ROS These findings may lead better patients who have infertility issues.

Language: Английский

Citations

2
Synthesis, Biological Evaluation, Molecular Docking, Molecular Dynamics, and ADME Studies of Novel Thiouracil Derivatives as Dual Inhibitors of Butyrylcholinesterase and Acetylcholinesterase Enzymes DOI
Asma K. Alshamari, Nasser A. Hassan, Odeh A. O. Alshammari

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141154 - 141154

Published: Dec. 1, 2024

Language: Английский

Citations

1
Antidiabetic Potential of Abelmoschus manihot Flower Extract: In Vitro and Intracellular Studies DOI Creative Commons

Shih‐Wei Wang,

Thung‐Lip Lee,

Tzu-Hsien Chang

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(8), P. 1211 - 1211

Published: July 26, 2024

(L.) Medic flower (AMf) exhibits both nutritional value and bioactivities such as antioxidative, anti-inflammatory, neuroprotective, cardioprotective, hepatoprotective effects. The aim of this investigation was to examine the potential impact three different solvent extracts AMf: supercritical CO

Language: Английский

Citations

0