Caralluma tuberculata (Chongan): Chemical Profiling, Antioxidant, Anticancer, Antibacterial and Antidiabetic Potential supported by In Silico Evidence

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(13)

Published: April 1, 2025

Abstract Caralluma tuberculata , a medicinal plant of the Apocynaceae family, has long been used to treat inflammation, oxidative stress, and metabolic problems. This study aimed analyze phytochemical composition aerial parts C. evaluate its biological activities, which included antioxidant, anticancer, antibacterial, antidiabetic properties. The were analyzed using GC–MS. Total phenolic content (TPC) total flavonoid (TFC) determined by Folin Ciocalteu aluminum chloride methods, respectively. In vitro activities performed. silico molecular docking was utilized Maestro 11.5 from Schrödinger suite. TPC (83.12 ± 1.26 mg GAE/g extract) extract richer compared TFC (47.45 1.37 QE/g exhibited moderate antioxidant activity in DPPH (IC 50 : 127.99 1.72 µg/mL) ABTS 182.61 1.88 assays. It cytotoxic MCF‐7 with IC = 161.62 1.92 µg/mL HepG2 cells values 151.87 2.15 regulated apoptotic pathways, increasing pro‐apoptotic gene expression. Antibacterial studies revealed broad range action, particularly against Gram‐positive bacteria. tuberculate's had minimum bactericidal concentration (MIC) ranging 6.25 µg/mL. effectively inhibited α‐amylase α‐glucosidase, indicating potential effects, 317.12 2.17 372.14 1.64 µg/mL, Molecular that 2,3‐dihydro‐3,5‐dihydroxy‐6‐methyl‐4h‐pyran‐4‐one, 8,8‐Dimethyl‐4‐methylene‐1‐oxaspiro [2.5] oct‐5‐ene, 2,5‐Monomethyl molecules identified C . most active sites three receptors studied. conclusion, diverse profile promising properties, making it prospective option for developing therapies disorders, infections, cancer, age‐related illnesses.

Language: Английский

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Exploring Ginseng Bioactive Compound’s Role in Hypertension Remedy: An In Silico Approach

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 648 - 648

Published: April 28, 2025

Background/Objectives: Ginseng has been a traditional remedy for centuries, known its diverse benefits such as anti-inflammation, antioxidant, bactericidal, fungicidal antidiabetic, and anticancer effects. This study employs network pharmacology approach with molecular dynamics simulation to investigate the potential mechanisms through which ginseng-derived compounds control hypertension. Methods: The total of 70 bioactive were identified from literature classified ginsenosides, fall under Protopanaxadiol-type Protopanaxatriol-type Ocotillol-type saponins. target proteins related hypertension collected drug bank, interactions between examined using STRING 12.0 Cytoscape 3.10.1. Bioinformatics tools used analyze biological enrichment genes. core targets extracted subjected docking studies. Similarly, score below −6.0 kcal/mol was further visualized by performing see binding affinity complexes. Finally, pharmacokinetics toxicity evaluated computational tools. Results: Molecular results revealed that Floralquinquenoside C, Ginsenoside Rg6, Notoginsenoside T1, B exhibited strong stability Angiotensin-converting enzyme (ACE) Carbonic Anhydrase-I (CA-I), alters renin–angiotensin system, calcium signaling pathway, adrenergic in cardiomyocytes, c-GMP-PKG etc., regulate high blood pressure. Conclusions: show phytochemicals ginseng could act candidates management hypertension, may help minimize side effects caused synthetic anti-hypertensive drugs available on market.

Language: Английский

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Phytochemical Assessment and Potential Pharmacological Activity of Moringa Oleifera Extract

Pharmacophore, Journal Year: 2024, Volume and Issue: 15(4), P. 46 - 53

Published: Jan. 1, 2024

Language: Английский

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Echinacea purpurea and Onopordum acanthium Combined Extracts Cause Immunomodulatory Effects in Lipopolysaccharide-Challenged Rats

Plants, Journal Year: 2024, Volume and Issue: 13(23), P. 3397 - 3397

Published: Dec. 3, 2024

and

Language: Английский

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