Advances in the study of polysaccharide-based hydrogel wound dressings
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 142134 - 142134
Published: March 1, 2025
Language: Английский
Effects of Saffron Supplementation on Glycolipid Metabolism and Blood Pressure in Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Xiaolei Zhang,
No information about this author
Jinxin Miao,
No information about this author
Yagang Song
No information about this author
et al.
Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
ABSTRACT
Saffron
is
a
traditional
herbal
medicine
used
to
treat
conditions
associated
with
metabolic
syndrome
(MetS).
However,
the
conclusions
of
relevant
clinical
studies
have
been
inconsistent.
This
study
aimed
assess
impact
saffron
supplementation
on
metabolism
glycolipids
and
blood
pressure
in
individuals
MetS
related
disorders.
Web
Science,
PubMed,
Cochrane
Library,
Scopus,
Embase
were
comprehensively
searched
for
investigating
disorders
up
February
2024.
Stata
17.0
was
conduct
Meta‐analysis.
Twenty‐five
randomized
controlled
trials
(RCTs)
included
this
study,
involving
1486
participants
conditions.
Compared
placebo,
triggered
significant
reductions
fasting
glucose
(FBG)
(WMD:
−6.67
mg/dL;
95%
CI:
−10.55,
−2.78;
p
=
0.001;
I
2
50.0%),
glycosylated
hemoglobin
A1c
(HbA1c)
−0.25%;
−0.35,
−0.14;
<
0.0%),
total
cholesterol
(TC)
−4.77
−8.83,
−0.71;
0.021;
31.8%),
systolic
(SBP)
−1.15
mmHg;
−1.66,
−0.64;
41.8%),
diastolic
(DBP)
−1.61
−1.88,
−1.34;
7.0%).
no
changes
observed
homeostatic
model
assessment
insulin
resistance
(HOMA‐IR),
triglyceride
(TG),
low‐density
lipoprotein
(LDL‐C),
high‐density
(HDL‐C),
body
mass
index
(BMI),
waist
circumference
(WC).
has
an
improving
effect
FBG,
HbA1c,
TC,
DBP,
SBP
patients
Nonetheless,
additional
high‐quality
RCTs
diverse
ethnic
populations
are
necessary
validate
effect.
Language: Английский
Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(7), P. 840 - 840
Published: June 21, 2024
It
was
previously
reported
that
crocin,
a
water-soluble
carotenoid
isolated
from
the
Language: Английский
Vitamin C and Gallic Acid Ameliorate Motor Dysfunction, Cognitive Deficits, and Brain Oxidative Stress in a Valproic Acid‐Induced Model of Autism
Brain and Behavior,
Journal Year:
2025,
Volume and Issue:
15(2)
Published: Feb. 1, 2025
ABSTRACT
Purpose
Autism,
a
developmental‐neurodegenerative
disorder,
often
manifests
as
social
communication
difficulties
and
has
been
correlated
to
oxidative
stress
in
the
brain.
Vitamins
C
gallic
acid
(GA)
possess
potent
antioxidant
properties,
making
them
potential
candidates
for
addressing
autism‐related
issues.
This
study
examined
influence
of
vitamin
(Vit
C)
GA
on
behavioral,
motor,
cognitive
performance,
along
with
assessment
brain
markers,
using
an
experimental
model
autism.
Method
Fourteen
female
rats
were
divided
into
saline
valproic
(VPA)
groups,
mating
mature
male
generated
offspring.
VPA
(500
mg/kg)
was
injected
intraperitoneally
(i.p.)
gestational
day
(GD)
12.5.
Male
pups
remained
undisturbed
29
days.
On
postnatal
(PND)
30,
48
randomly
selected
administered
daily
injections
Vit
(30
mg/kg,
i.p.)
or
4
weeks
(PND
38–65).
Behavioral
assessments
conducted
before
after
treatment
30–37
66–73).
Animals
then
anesthetized,
their
brains
analyzed
markers.
Finding
The
prenatal
VPA‐induced
autism
increased
nociceptive
threshold,
heightened
anxiety‐like
behaviors,
impaired
balance
power,
delayed
spatial
learning,
elevated
malondialdehyde,
decreased
glutathione
catalase
levels
Administration
effectively
mitigated
these
anomalies.
Conclusions
could
potentially
alleviate
motor
deficits,
markers
rat
model.
underscores
viability
pharmacological
interventions
treating
autistic
dysfunction.
Language: Английский
Combination of Saffron (Crocus sativus), Elderberry (Sambucus nigra L.) and Melilotus officinalis Protects ARPE-19 Cells from Oxidative Stress
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1496 - 1496
Published: Feb. 11, 2025
Oxidative
stress
is
considered
a
common
underlying
mechanism
in
many
retinal
degenerative
diseases
and
often
associated
with
inflammation.
The
use
of
dietary
supplements
containing
Saffron
has
beneficial
effects
ocular
diseases,
though
the
molecular
mechanisms
are
still
unclear.
In
this
study,
we
investigated
how
can
exert
protective
against
oxidative
damage
pigment
epithelial
cells
(ARPE-19)
whether
its
combination
Elderberry
Melilotus
may
have
additive
effects.
ARPE-19
were
pretreated
alone
or
mix
Saffron,
Melilotus,
then
exposed
to
hydrogen
peroxide
(H2O2)
for
3
h.
Afterwards,
evaluated
cell
viability,
inflammatory
status.
Our
results
showed
that
H2O2
reduced
viability
total
glutathione
levels,
while
increasing
caspase-3,
caspase-1
LDH
activity.
Moreover,
triggered
ROS
production,
oxidation
IL-1β
secretion.
Pretreatments
counteract
these
damaging
by
improving
reducing
enhancing
SOD2
expression.
Pretreatment
activated
NRF2
pathway
was
more
effective
than
preventing
activation.
These
findings
suggest
could
therapeutic
potential
prevention
treatment
diseases.
Language: Английский
Effects of Letrozole and Crocin Combination on Sperm Motility and Biochemical Markers in Azoospermia: Insights from Gene Expression Analysis
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Abstract
Azoospermia,
characterized
by
the
absence
of
sperm
in
ejaculation,
is
a
severe
male
infertility
condition
resulting
from
defects
spermatogenesis
or
testicular
duct
system.
DNA-alkylating
agents,
often
chemical
drugs,
contribute
to
infertility,
while
antioxidants
play
crucial
role
addressing
fertility
issues
couples
facing
subfertility.
Traditional
medicinal
plants,
particularly
saffron,
have
been
recognized
for
their
fertility-enhancing
effects.
Crocins
saffron
are
noted
potential
improve
indicators
rat
models.
This
study
aimed
investigate
effects
combination
letrozole
and
crocin
on
motility
biochemical
markers
azoospermia,
complemented
gene
expression
analysis.
Thirty
Wistar
rats
were
divided
into
five
groups:
control,
azoospermia
with
letrozole,
crocin,
both
crocin.
Azoospermia
was
induced
using
10
mg
intraperitoneal
injection
busulfan
over
ten
days.
Subsequent
analyses
included
histopathological,
molecular,
hormonal
assessments,
data
analyzed
Graph
Prism
software.
The
treatment
significantly
improved
compared
group,
reducing
control
group.
Additionally,
there
an
increase
total
count,
Total
Antioxidant
Capacity
(TAC),
testosterone
levels,
accompanied
decrease
Oxidant
Status
(TOS)
enzyme
activity
(P
<
0.05).
QRT-PCR
analysis
indicated
decreased
GDNF
0.001)
but
increased
group
0.001).
Likewise,
5-alpha-reductase
showed
significant
Therefore,
synergistic
administration
holds
promise
mitigating
DNA
damage
caused
busulfan,
potentially
long-term
bone
marrow
improving
outcomes.
Language: Английский
Natural polyphenols as therapeutic candidates for mitigating neuropsychiatric symptoms in post-traumatic stress disorder: Evidence from preclinical studies
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Journal Year:
2024,
Volume and Issue:
136, P. 111230 - 111230
Published: Dec. 23, 2024
Language: Английский