Role of plasma metabolome in mediating the effect of plasma lipidome on NAFLD: a Mendelian randomization study DOI Creative Commons

Zhuyuan Zheng,

Shaojie Yang,

Wanlin Dai

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 23, 2025

Background This study explored the causal connection among plasma lipidome, nonalcoholic fatty liver disease (NAFLD), and potential metabolome mediators through Mendelian randomization (MR). Methods We obtained summary statistics for 179 lipidome traits ( N = 7,174), 1,400 8,299), one NAFLD trait from publicly available genome-wide association studies. A two-sample MR analysis was conducted to infer causality. Additionally, multiple sensitivity analyses were assess heterogeneity, horizontal pleiotropy, robustness of findings. MetaboAnalyst 6.0 used pathway identified lipids metabolites. Furthermore, we mediation whether effect on mediated by metabolome. Results The predicted a genetically determined relationship between lipidomes NAFLD. No compelling proof found that influenced risk five mentioned earlier. Based established relationships metabolites, eight metabolic pathways are closely associated with Our revealed six relationships, indicating specific pleiotropy in analysis. Conclusions In summary, our lipidomes, metabolomes, Certainly, impact is not limited need further investigate into other possible mediators. These factors may become new biomarkers contributing its prevention, diagnosis, treatment.

Language: Английский

Menopause and metabolic dysfunction-associated steatotic liver disease DOI
Stergios A. Pοlyzos, Dimitrios G. Goulis

Maturitas, Journal Year: 2024, Volume and Issue: 186, P. 108024 - 108024

Published: May 14, 2024

Language: Английский

Citations

10
Excess cardiovascular mortality in men with non-alcoholic fatty liver disease: A cause for concern! DOI Open Access
Akash Batta, Juniali Hatwal

World Journal of Cardiology, Journal Year: 2024, Volume and Issue: 16(7), P. 380 - 384

Published: July 24, 2024

Non-alcoholic fatty liver disease (NAFLD) has emerged as the commonest cause of chronic worldwide in recent years. With time, our understanding NAFLD evolved from an isolated condition to a systemic with significant manifestations beyond liver. Amongst them, cardiovascular diseases (CVDs) are most important and clinically relevant. Recent research supports strong independent link between NALFD CVD shared risk factors pathophysiology. Female sex hormones well known not only protect against pre-menopausal females, but also contribute improved adipose tissue function preventing its deposition. highlights increased major adverse cardiovascular-cerebral events (MACCE) amongst male compared females. Further, racial variation was observed MACCE outcomes NAFLD, excess mortality Native Americans Asian Pacific Islanders other races.

Language: Английский

Citations

5
Role of plasma metabolome in mediating the effect of plasma lipidome on NAFLD: a Mendelian randomization study DOI Creative Commons

Zhuyuan Zheng,

Shaojie Yang,

Wanlin Dai

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 23, 2025

Background This study explored the causal connection among plasma lipidome, nonalcoholic fatty liver disease (NAFLD), and potential metabolome mediators through Mendelian randomization (MR). Methods We obtained summary statistics for 179 lipidome traits ( N = 7,174), 1,400 8,299), one NAFLD trait from publicly available genome-wide association studies. A two-sample MR analysis was conducted to infer causality. Additionally, multiple sensitivity analyses were assess heterogeneity, horizontal pleiotropy, robustness of findings. MetaboAnalyst 6.0 used pathway identified lipids metabolites. Furthermore, we mediation whether effect on mediated by metabolome. Results The predicted a genetically determined relationship between lipidomes NAFLD. No compelling proof found that influenced risk five mentioned earlier. Based established relationships metabolites, eight metabolic pathways are closely associated with Our revealed six relationships, indicating specific pleiotropy in analysis. Conclusions In summary, our lipidomes, metabolomes, Certainly, impact is not limited need further investigate into other possible mediators. These factors may become new biomarkers contributing its prevention, diagnosis, treatment.

Language: Английский

Citations

0