The Potential of Human Pulmonary Mesenchymal Stem Cells as Vectors for Radiosensitizing Metallic Nanoparticles: An In Vitro Study DOI Open Access

Angélique Arcambal,

Axelle Septembre‐Malaterre, Sabrina Pesnel

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3239 - 3239

Published: Sept. 23, 2024

Background/Objectives: Metallic nanoparticles (NPs) exhibit interesting radiosensitizing effects, and finding a way to accurately deliver them appears be crucial. Due their tumor tropism, mesenchymal stem cells (MSCs) represent strategic approach. Therefore, we aimed evaluate the impact of core–shell Fe3O4@Au NPs on functionality human pulmonary MSCs (HPMSCs). Methods/Results: The results showed that 100 µg/mL NPs, accumulated in HPMSCs (revealed by Prussian blue staining), did not alter cell viability as assessed counting, MTT, LDH assays. However, caspase 9 Bcl2 gene expression, evaluated RT-qPCR, was regulated 72 h after exposure NPs. Moreover, also decreased proinflammatory cytokine/chemokine secretions, except for CXCL8 (ELISA). These modulations were associated with downregulation AMPK expression at 24 h. In contrast, modulate VEGF, PI3K, or PDGF expression. Nevertheless, decrease VEGF secretion observed Interestingly, Nrf2 but they regulate genes encoding Nox4 HMOX-1. Additionally, increased ROS production, suggesting redox imbalance. Conclusions: Finally, affect HPMSCs’ proangiogenic/tumorigenic markers. findings are encouraging investigating effects delivered sites combination radiation.

Language: Английский

Nanoparticle-Based Drug Delivery Systems in Inhaled Therapy: Improving Respiratory Medicine DOI Creative Commons
Elena Cojocaru,

Ovidiu Rusalim Petriș,

Cristian Cojocaru

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1059 - 1059

Published: Aug. 12, 2024

Inhaled nanoparticle (NP) therapy poses intricate challenges in clinical and pharmacodynamic realms. Recent strides have revolutionized NP technology by enabling the incorporation of diverse molecules, thus circumventing systemic clearance mechanisms enhancing drug effectiveness while mitigating side effects. Despite established success delivery oncology other disciplines, exploration inhaled therapies remains relatively nascent. NPs loaded with bronchodilators or anti-inflammatory agents exhibit promising potential for precise distribution throughout bronchial tree, offering targeted treatment respiratory diseases. This article conducts a comprehensive review applications medicine, highlighting their merits, ranging from heightened stability to exacting lung-specific delivery. It also explores cutting-edge technologies optimizing NP-loaded aerosol systems, complemented insights gleaned trials. Furthermore, examines current future prospects NP-based therapies. By synthesizing data perspectives, underscores transformative promise NP-mediated addressing chronic conditions such as obstructive pulmonary disease, pressing global health concern ranked third mortality rates. overview illuminates evolving landscape inhalation therapies, presenting optimistic avenues advancing medicine improving patient outcomes.

Language: Английский

Citations

11
Laser-fabricated Metal Oxide Core–shell Nanoparticles for Biomedical Applications: a Mini Review DOI

Sarah M. Talib,

Adawiya J. Haider, Sharafaldin Al-Musawi

et al.

Plasmonics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

Citations

1
State-of-the-art application of nanoparticles in radiotherapy: a platform for synergistic effects in cancer treatment DOI Creative Commons
Mehrnaz Mostafavi, Farhood Ghazi,

Mahboobeh Mehrabifard

et al.

Strahlentherapie und Onkologie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Language: Английский

Citations

4
Radiosensitization of Rare-Earth Nanoparticles Based on the Consistency Between Its K-Edge and the X-Ray Bremsstrahlung Peak DOI Creative Commons
Xiang Zhu, Chenxia Qiu, Jiaojiao Cao

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(2), P. 41 - 41

Published: Jan. 24, 2025

Nanoparticle-based X-ray radiosensitization strategies have garnered significant attention in recent years. However, the underlying mechanisms of remain incompletely understood. In this work, we explore influence K-edge effect absorption nanomaterials on sensitization. Due to alignment thulium (Tm) with Bremsstrahlung peak energy spectrum medical accelerators, following four different rare-earth varying Tm percentages were designed: NaTmF4, NaTm0.6Lu0.4F4, NaTm0.4Lu0.6F4, and NaLuF4. We evaluated ability generate secondary electrons reactive oxygen species (ROS) these nanoparticles. The radiosensitizing was through clonogenic assays. Our results showed that affected electron generation but did not significantly change ROS production. Nonetheless, NaTmF4 induced marginally more DNA damage U87 cells than other cell types. also exhibited superior efficacy against tumor cells. This shows play pivotal roles radiosensitization, which might be crucial improving cancer treatment enhanced radiation therapy outcomes.

Language: Английский

Citations

0
Optical Fiber Biosensors with ZnO Nanowires and Nanoparticles of Fe3O4 and Au for Rapid Detection of Enrofloxacin Residues in Food DOI
Fei Liu, Ragini Singh, Carlos Marques

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(21), P. 24417 - 24425

Published: Oct. 23, 2024

In this paper, an enhanced optical fiber biosensor based on nanomaterials is proposed for the detection of enrofloxacin residues in food. Single mode (SMF), multimode (MMF), and four-core (FCF) were fused to fabricate SMF-MMF-FCF-MMF-SMF structure. Then, a three times tapered (T3) structure was fabricated FCF. The WaveFlex T3-SMF-MMF-FCF-MMF-SMF fabricated. surface modified with gold nanoparticles, zinc oxide nanowires (ZnO-NWs), Fe3O4 Au nanocomposites stimulate enhance localized plasmon resonance (LSPR) effect. monoclonal antibody fixed probe order achieve specific differentiation detection. performance sensor verified by testing 0–1000 μg/mL solutions. sensitivity 1.89 nm/ln (μg/mL), limit (LoD) 0.16 μg/mL. addition, method has good reproducibility, reusability, repeatability, stability, selectivity. It also obtained promising results real environment (milk, juice, pork, chicken) tests can be used

Language: Английский

Citations

1
Optimization of the Gold Layer in Multifunctional Theranostic Core-Shell Magnetic Nanoparticles (MNP@Au) for Radiation Dose Enhancement in an MRI-Guided Proton Therapy System: A Monte Carlo Simulation DOI

Mohammadreza Parishan,

Rasool Safari, Maryam Bordbar

et al.

Radiation Physics and Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 112477 - 112477

Published: Dec. 1, 2024

Language: Английский

Citations

1
The Potential of Human Pulmonary Mesenchymal Stem Cells as Vectors for Radiosensitizing Metallic Nanoparticles: An In Vitro Study DOI Open Access

Angélique Arcambal,

Axelle Septembre‐Malaterre, Sabrina Pesnel

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3239 - 3239

Published: Sept. 23, 2024

Background/Objectives: Metallic nanoparticles (NPs) exhibit interesting radiosensitizing effects, and finding a way to accurately deliver them appears be crucial. Due their tumor tropism, mesenchymal stem cells (MSCs) represent strategic approach. Therefore, we aimed evaluate the impact of core–shell Fe3O4@Au NPs on functionality human pulmonary MSCs (HPMSCs). Methods/Results: The results showed that 100 µg/mL NPs, accumulated in HPMSCs (revealed by Prussian blue staining), did not alter cell viability as assessed counting, MTT, LDH assays. However, caspase 9 Bcl2 gene expression, evaluated RT-qPCR, was regulated 72 h after exposure NPs. Moreover, also decreased proinflammatory cytokine/chemokine secretions, except for CXCL8 (ELISA). These modulations were associated with downregulation AMPK expression at 24 h. In contrast, modulate VEGF, PI3K, or PDGF expression. Nevertheless, decrease VEGF secretion observed Interestingly, Nrf2 but they regulate genes encoding Nox4 HMOX-1. Additionally, increased ROS production, suggesting redox imbalance. Conclusions: Finally, affect HPMSCs’ proangiogenic/tumorigenic markers. findings are encouraging investigating effects delivered sites combination radiation.

Language: Английский

Citations

0