SILVER NANOPARTICLES FROM ASCORBIC ACID: BIOSYNTHESIS, CHARACTERIZATION, IN VITRO SAFETY PROFILE, ANTIMICROBIAL ACTIVITY AND PHYTOTOXICITY

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: 325, P. 129715 - 129715

Published: July 14, 2024

Language: Английский

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How Nanomaterials Act against Bacterial Structures? A Narrative Review by Focusing on Molecular Mechanism of the Nanoparticles

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 196, P. 107002 - 107002

Published: Oct. 10, 2024

Language: Английский

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Nickel Selenide‐Loaded PANI/PEO Fibers for Boosted Wound Healing Response in Rabbits

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(3)

Published: March 1, 2025

ABSTRACT Wound healing is a dynamic biological process that leads to the repair of damaged body tissues and restores their ability function as protective barriers. There are several approaches handling treating skin wounds; however, new efficient procedures must be developed cope with inadequacies current methods, such longer recovery time. In our novel research, we used NiSe NPs ointment NiSe‐incorporated PANI/PEO fibers for wound healing. The materials‐related characteristics were studied by UV/visible spectroscopy, FTIR, SEM, DLS, XRD. SEM images illustrate rod‐like structure NiSe, while bead‐free NiSe‐based conformed from an average diameter 330 nm. An crystal size 6.2 nm measured XRD pattern. antibacterial antioxidant properties showed exhibited better response than less toxicity. give excellent potential 89.5% ± 1.18% 95.6% 0.25%, respectively. Healing tissue regeneration evaluated clinically using histopathology interleukin‐6, which indicated effective recovery.

Language: Английский

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Defensin: The immune system regulatory factor against peripheral nerve disease

Brain‐X, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 1, 2025

Abstract Peripheral nerve disease is commonly encountered in orthopedics, neurology, and neurosurgery. Due to its large population, a substantial number of patients are affected by these conditions China. has high disability rate current treatments show poor clinical efficacy, resulting heavy burden for the country's healthcare system. Defensins widespread proteins, found animals, plants, fungi, with multiple subtypes able kill variety pathogens. As regulatory factors immune system, defensins influence bodily function participating inflammatory processes, responses, pathogen resistance; they can affect all stages conduction play an important role lesions peripheral effector nerves. This article provides review possible roles mechanisms disease.

Language: Английский

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Keratin/Copper Complex Electrospun Nanofibers for Antibacterial Treatments: Property Investigation and In Vitro Response

Materials, Journal Year: 2024, Volume and Issue: 17(10), P. 2435 - 2435

Published: May 18, 2024

The frontiers of antibacterial materials in the biomedical field are constantly evolving since infectious diseases a continuous threat to human health. In this work, waste-wool-derived keratin electrospun nanofibers were blended with copper by an optimized impregnation procedure fabricate membranes intrinsic biological activity, excellent degradability and good cytocompatibility. keratin/copper complex multi-analytically characterized main differences their physical-chemical features related crosslinking effect caused Cu2+. Indeed, ions modified thermal profiles, improving stability (evaluated differential scanning calorimetry thermogravimetry), changed infrared vibrational (determined spectroscopy) chemical composition (studied X-ray energy-dispersive spectroscopy probe optical emission spectrometry). process also affected morphology, leading partial nanofiber swelling, as evidenced electron microscopy analyses. Then, successfully tested against gram-negative bacteria, Escherichia coli. Regarding cytocompatibility, vitro assays performed L929 cells showed levels cell adhesion proliferation (XTT assay), no significant cytotoxic effect, comparison bare nanofibers. Given these results, material described work can be suitable for use antibiotic-free fibers skin wound dressing or guided tissue regeneration.

Language: Английский

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Copper Nanoparticle Loaded Electrospun Patches for Infected Wound Treatment: From Development to In-Vivo Application

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2733 - 2733

Published: Sept. 27, 2024

This study investigates the development and application of electrospun wound dressings based on polylactic acid (PLA) nanofibers, chitosan, copper nanoparticles (CuNPs) for treatment purulent skin wounds. The materials were evaluated their structural, antibacterial, healing properties using an animal model. PLA/Ch-CuNPs demonstrated most significant antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, surpassing other tested materials. integration CuNPs into nanofiber matrices not only enhanced antimicrobial efficacy but also maintained structural integrity biocompatibility dressings. In vivo experiments a rat model showed that facilitated faster with reduced exudative inflammatory responses compared to PLA alone or PLA-CuNPs. Histological immunohistochemical assessments revealed combination PLA, mitigated processes promoted tissue regeneration more effectively. However, this identified potential toxicity related ions, emphasizing need careful optimization CuNP concentrations. These findings suggest could serve as potent, cost-effective dressing broad-spectrum properties, addressing challenge antibiotic-resistant infections enhancing outcomes.

Language: Английский

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Pharmaceutical Applications of Peptides Formulated in Biocomposite Nanomaterials

Nanostructure science and technology, Journal Year: 2024, Volume and Issue: unknown, P. 25 - 43

Published: Jan. 1, 2024

Language: Английский

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