Future Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Nov. 20, 2024
Abstract
Background
Lung
cancer
remains
a
leading
type,
but
current
chemotherapy
is
limited
by
issues
including
poor
drug
delivery,
toxicity,
and
resistance.
To
address
these
challenges,
we
developed
novel
PLGA-PEG-LHRH
(PPL)
nanoconjugate
system
for
improved
delivery.
Curcumin,
known
its
anticancer
P-gp
inhibition
properties,
was
co-loaded
with
bcl2siRNA
(bclsR)
to
inhibit
the
bcl2
protein,
thus
overcoming
both
resistance
mechanisms.
Results
The
PPL
conjugate
successfully
synthesized
characterized
using
FTIR,
1
H
NMR,
XRD,
XPS
BCA
assay.
Curcumin
bclsR-loaded
PLGA
nanoemulsions
were
prepared
double
emulsion
solvent
evaporation
method
characterized.
optimized
had
size
of
179
±
16
nm,
favorable
zeta
potential,
high
entrapment,
confirmed
via
TEM.
Controlled
release
studies
indicated
83%
within
24
h.
In
vitro
revealed
significant
cytotoxicity
against
A549
lung
cells,
showing
IC50
8.24
µg/mL
compared
21.26
plain
curcumin.
Enhanced
cellular
uptake
effective
targeting
cells
observed.
Molecular
analyses
demonstrated
downregulation
MDR1
Bcl2
RNA
protein
expression,
highlighting
nanoconjugates'
ability
suppress
Pharmacokinetic
in
Wistar
rats
showed
superior
plasma
concentrations,
half-life,
AUC
versus
pure
suspension.
Biodistribution
increased
accumulation
lungs.
vivo
efficacy
Balb/c
mice
higher
tumor
ratios
CUR-siRNA
NPs
(66.89%)
CUR-PPL
(59.84%)
which
further
TNFα
p53
levels
blood.
Histopathological
good
healing
NP-
NP-treated
Conclusion
From
study,
it
may
be
concluded
that
system,
loaded
curcumin
bcsR,
can
potentially
effective,
multifunctional
targeted
approach
therapy.
Graphical
Pharmaceutical Development and Technology,
Journal Year:
2024,
Volume and Issue:
29(7), P. 703 - 718
Published: July 18, 2024
Letrozole
(LTZ)
is
used
as
first-line
treatment
for
hormone-positive
breast
cancer
(BC)
in
postmenopausal
women.
However,
its
poor
aqueous
solubility
and
permeability
have
reduced
clinical
efficacy.
Herein,
we
developed
LTZ-nanotransferosomes
(LTZ-NT)
to
address
above
mentioned
issues.
The
LTZ-NT
were
optimized
statistically
using
Design
Expert
Polyphenols
(PFs)
are
compounds
found
in
fruits
and
vegetables,
known
for
their
health-related
benefits,
mainly
including
antioxidant,
antiinflammatory,
anticancer
properties.
However,
efficacy
is
limited
by
poor
bioavailability
due
to
issues
like
low
solubility,
rapid
metabolism,
extensive
excretion.
Thus,
research
has
focused
on
improving
delivery
systems,
such
as,
example,
nanoparticles,
hydrogels,
cocrystals,
or
conjugation
with
carrier
molecules,
which
may
protect
PFs
from
degradation,
improve
and/or
facilitate
targeted
cancer
cells.
promising
modulating
cancer-related
pathways
cell
proliferation
death,
metastatic
invasion,
though
translation
patients
hindered
complex
mechanisms.
This
review
analyzes
factors
that
affect
PF
bioavailability,
evidences
of
vivo
effects
animal
models
mechanisms,
results
clinical
trials,
strategies
enhance
bioavailability.
The
idea
need
directly
interact
the
challenged.
Future
aims
optimize
combine
standard
treatments,
explore
epigenetic
effects,
modulation
tumor
microenvironment,
interactions
gut
microbiota.
Advances
personalized
medicine
structural
modifications
stability
absorption
could
further
potential.
Despite
challenges,
remain
a
avenue
complementary
oncotherapy
solutions.
Drug Development and Industrial Pharmacy,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 9
Published: Oct. 27, 2024
The
study
aimed
at
designing
a
pH
sensitive
Lipid
polymeric
Hybrid
nanoparticle
(LPHNP)
for
targeted
release
of
Paclitaxel
(PTX)
and
Curcumin
(CUR)
in
breast
cancer.
