Natural Bioactive Compounds in the Management of Type 2 Diabetes and Metabolic (Dysfunction)-Associated Steatotic Liver Disease

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 279 - 279

Published: Feb. 19, 2025

Type 2 diabetes (T2D) and metabolic (dysfunction)-associated steatotic liver disease (MASLD) affect a growing number of individuals worldwide. T2D MASLD often coexist substantially elevate the risk adverse hepatic cardiovascular clinical outcomes. Several common pathogenetic mechanisms are responsible for onset progression, including insulin resistance, oxidative stress, low-grade inflammation, among others. The latter can also be induced by gut microbiota its derived metabolites. Natural bioactive compounds (NBCs) have been reported their therapeutic potential in both MASLD. A large amount evidence obtained from trials suggests that like berberine, curcumin, soluble fibers, omega-3 fatty acids exhibit significant hypoglycemic, hypolipidemic, hepatoprotective activity humans may employed as adjunct therapy management. In this review, role most studied NBCs management is discussed, emphasizing recent supporting these compounds' efficacy safety. Also, prebiotics act against dysfunction modulating evaluated.

Language: Английский

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The Burden of Non-Malignant Metabolic Dysfunction-Associated Steatotic Liver Disease in the Western Pacific Region: A Systematic Analysis from 1990 to 2021

Published: Jan. 1, 2025

Background: The burden of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing, yet there little regional understanding in the Western Pacific. This study aims mainly to report latest MASLD and trends Pacific region for period 1990-2021.

Language: Английский

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Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: Challenges and opportunities

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 24, 2025

The potential of induced pluripotent stem cells (iPSCs) for modeling and treating metabolic associated fatty liver disease (MAFLD) steatohepatitis (MASH) is emerging. MAFLD a growing global health concern, currently with limited treatment options. While primary mesenchymal hold promise, iPSCs offer versatile alternative due to their ability differentiate into various cell types, including iPSC-derived cells. However, challenges remain, optimizing differentiation protocols, ensuring safety, addressing tumorigenicity risks. In addition, the possibility generate complex cellular models, three-dimensional organoid which are closer representations human than animal models. Those models would also be valuable drug discovery personalized medicine approaches. Overall, derivatives new perspectives advancing MAFLD/MASH research developing novel therapeutic strategies. Further needed overcome current limitations translate this effective clinical applications.

Language: Английский

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Polysaccharides Extracted from Old Stalks of Asparagus officinalis L. Improve Nonalcoholic Fatty Liver by Increasing the Gut Butyric Acid Content and Improving Gut Barrier Function

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Nonalcoholic fatty liver disease (NAFLD) ranks among the most prevalent chronic diseases worldwide, yet effective treatments remain scarce. Old stalks of Asparagus officinalis L. are rich in polysaccharides. The anti-NAFLD mechanism polysaccharides from old A. (AP) requires further study. Here, we studied effects AP on NAFLD mice and its impact gut microbiota. intervention reduces blood lipids injury inflammation with NAFLD. Moreover, changed microbiota composition increased abundances butyric acid-producing bacteria, thereby increasing plasma concentration acid. Furthermore, regulated AMPK/SREBPs signaling pathway, affecting hepatic lipid synthesis. Additionally, improved barrier function reduced LPS levels, which subsequently inhibited LPS/TLR4/NF-κB alleviating model mice. Importantly, fecal transplant (FMT) outcomes demonstrated that AP-induced changes pathways. These data suggest ameliorates by regulating research provides a scientific foundation for use treatment

Language: Английский

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Clinical Insights into Non-Alcoholic Fatty Liver Disease and the Therapeutic Potential of Flavonoids: An Update

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 956 - 956

Published: March 9, 2025

Non-alcoholic fatty liver disease (NAFLD) is considered a significant global health issue related to serious metabolic disorders. However, effective pharmacological treatments are still limited. Flavonoids, wide group of polyphenol substances, exert anti-inflammatory and lipid-lowering effects in preclinical data. Thus, implementing these research findings clinical practice could significantly help manage NAFLD its consequences. This narrative review assesses the therapeutic potential flavonoids managing NAFLD. The collected randomized controlled trials (RCTs) meta-analyses RCTs from past five years concerning impact on A total 20 studies were selected according predetermined inclusion criteria, comprising thirteen seven meta-analyses. underscores beneficial management through enhancement lipid metabolism, reduction hepatic steatosis, provision actions. Clinical demonstrate that interventions rich flavonoids, including quercetin, epigallocatechin gallate, naringenin, isoflavones, substantially reduce fat content enhance enzyme profiles, with certain compounds exhibiting superior efficacy particular subgroups, such as older adults females. Nonetheless, whereas therapies diminish their effect fibrosis constrained. To sum up, exhibit supplementary for by enhancing function, inflammation. Additional extensive necessary create uniform treatment methods ascertain long-term advantages.

Language: Английский

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Relationship between albumin-corrected anion gap and non-alcoholic fatty liver disease: a cross-sectional analysis of NHANES 2017–2018

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 12, 2025

Objectives The objective of this study was to examine the correlation between albumin-corrected anion gap (ACAG) and non-alcoholic fatty liver disease (NAFLD) using data from National Health Nutrition Examination Survey (NHANES) 2017–2018. Methods A cross-sectional analysis conducted, comprising 4,379 participants, who were stratified into two groups: those with NAFLD without NAFLD. baseline characteristics compared most appropriate statistical tests. relationship ACAG levels assessed generalized linear models, adjustments made for potential confounding factors. threshold effects conducted piecewise regression. Furthermore, investigated in different age groups. Results mean participants significantly higher than that non-NAFLD (48.88 vs. 43.46 years, p < 0.001). presence associated (18.80 ± 0.24 18.10 0.19, In fully adjusted each 1-unit increase a increased risk under 60 years old ( β : 0.87, 95% CI: 0.05, 1.69, 0.05). younger elevated observed quartiles P trend <0.05). contrast, no significant associations identified aged older >0.05), suggesting age-specific differences Conclusion impact on is correlated, especially group, where are young people. may be reliable biomarker predicting clinical assessment, but its implementation should consider patient’s factor.

Language: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2837 - 2837

Published: March 21, 2025

There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.

Language: Английский

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Linghe Granules Reduces Hepatic Lipid Accumulation in Non-Alcoholic Fatty Liver Disease through Regulating Lipid Metabolism and Redox Balance

Phytomedicine, Journal Year: 2025, Volume and Issue: 141, P. 156654 - 156654

Published: April 2, 2025

Language: Английский

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Unlocking the Therapeutic Potential of Autophagy Modulation by Natural Products in Tackling Non‐Alcoholic Fatty Liver Disease

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

It is widely recognized that there currently no established treatment for individuals with Non-alcoholic Fatty Liver Disease (NAFLD). In recent years, has been a surge of interest in natural products derived from plants, driven by their minimal toxicity and notable efficacy. was reported could ameliorate NAFLD via various mechanisms. On the other hand, autophagy suggested to be involved pathogenesis NAFLD. The aim this review understand whether beneficial effects on are mediated affecting pathways. review, we have compiled data elucidating how these exhibit potential improve modulating core autophagic Specifically, demonstrate products, including resveratrol, berberine, curcumin, quercetin, punicalagin, epigallocatechin-3-gallate, apigenin, many others, regulate through key signaling pathways, such as AMPK/SIRT1/mTOR. Interestingly, compounds might activate or inhibit autophagy, depending context. We explore activation promotes degradation lipid droplets alleviates liver injury, while inhibition contributes reducing inflammation, apoptosis, pyroptosis, also resulting improved outcomes. Taken together, findings suggest targeting presents promising mechanism preventing treating

Language: Английский

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Thyroid hormone and the Liver

Hepatology Communications, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 19, 2024

It is known that thyroid hormone can regulate hepatic metabolic pathways including cholesterol, de novo lipogenesis, fatty acid oxidation, lipophagy, and carbohydrate metabolism. Thyroid action mediated by the receptor (THR) isoforms their coregulators, THRβ main isoform expressed in liver. Dysregulation of levels, as seen hypothyroidism, has been associated with dyslipidemia dysfunction-associated liver disease. Given beneficial effects metabolism advances illuminating use analogs such resmetirom therapeutic agents treatment disease, this review aims to further explore relationship between TH, liver, Herein, we summarize current clinical therapies highlight future areas research.

Language: Английский

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