Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota DOI Creative Commons
Yanbo Liu, Ying Zhou, Haoyue Zhang

et al.

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

Mechanisms coupling the mTOR pathway to chronic obstructive pulmonary disease (COPD) pathogenesis DOI
Ankita Goyal, Vishal Chopra, Kranti Garg

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Effects of the oral probiotic Familact on dyspnea management in COPD patients: A randomized controlled trial DOI

Mehdi Aghamohammadi,

Samad Ghodrati, Nooshin Jalili

et al.

Heart & Lung, Journal Year: 2025, Volume and Issue: 71, P. 63 - 68

Published: Feb. 27, 2025

Language: Английский

Citations

0
The synergistic link between sonic hedgehog signaling pathway and gut–lung axis: Its influential role toward chronic obstructive pulmonary disease progression DOI Open Access
Nidhi Mahajan, Vishal Chopra, Kranti Garg

et al.

Developmental Dynamics, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Sonic Hedgehog (SHH) is an evolutionarily conserved signaling pathway essential for embryonic development, tissue homeostasis, and tumorigenesis. Aberrant activation of the SHH induces various types cancer different immune dysregulation. extremely important morphogen during lung as it regulates interaction between epithelial mesenchymal transitions (EMT) in airways. Cigarette smoking triggers EMT activates pathway, which leads to damage development diseases, such COPD, a smoker's disease. also directs gut–lung axis (GLA) formation via epithelial–mesenchymal signaling. The abruption or alteration GLA responsible COPD pathogenesis. In this review, we elucidate overview its inhibitor HHIP, SHH's prominence dysregulation pathogenesis link with clinical features. We provide insights into linked nicotine their influence on

Language: Английский

Citations

0
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota DOI Creative Commons
Yanbo Liu, Ying Zhou, Haoyue Zhang

et al.

Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964

Published: April 8, 2025

The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.

Language: Английский

Citations

0