In Vitro Antimicrobial Efficacy Assessment of Ethanolic, Aqueous, and Dual Solvent Extracts of Mushroom Ganoderma lucidum: Genomic and Morphological Analysis DOI Creative Commons
Akamu J. Ewunkem,

Lydia Merrills,

Zahirah J. Williams

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1109 - 1109

Published: Nov. 21, 2024

Background: Infectious diseases caused by bacteria are life-threating and among the major causes of death in world. Antibiotics have offered humans a new approach to infection control. reckoned as “magic bullets” for fight against bacterial infections, therefore increasing life expectancy decreasing mortality morbidity. However, overuse antibiotics has resulted persistent growth resistant pathogens. New antimicrobial approaches pathogens being examined. Mushrooms seem be promising, possibly more efficient, alternative method that conventional antimicrobials. This work aimed investigate phytochemical constituents potential ethanolic, aqueous, dual solvent extracts mushroom Ganoderma lucidum. Methods: The studies were carried out broth dilution Gram-positive Staphylococcus aureus Gram-negative Escherichia coli. present research was also examine genomic changes associated with G. lucidum S. E. Results: Our data quantitatively showed all found exhibit various degrees effects coli where ethanolic extract exhibited most potent activity. SEM images untreated cells normal cell characteristics while, after treatment lucidum, appeared damaged irregular surfaces wall defacement. results HPLC analysis aqueous consisted beta[1-3] glucans, ganoderic acid, triterpenoids. Genomic identified selective sweeps several genes growth, biosynthesis transport, stress. Conclusions: study concludes three solvents activity infectious causing morphological acquisition mutations genes. Therefore, may candidates preventing future. is reliable source agent can used diseases.

Language: Английский

Bioactive Secondary Metabolites in Mushrooms: A Focus on Polyphenols, Their Health Benefits and Applications DOI Creative Commons
Melinda Fogarasi, Silvia Amalia Nemeş, Anca Corina Fărcaş

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105166 - 105166

Published: Sept. 1, 2024

Language: Английский

Citations

8
In Vitro Antimicrobial Efficacy Assessment of Ethanolic, Aqueous, and Dual Solvent Extracts of Mushroom Ganoderma lucidum: Genomic and Morphological Analysis DOI Creative Commons
Akamu J. Ewunkem,

Lydia Merrills,

Zahirah J. Williams

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1109 - 1109

Published: Nov. 21, 2024

Background: Infectious diseases caused by bacteria are life-threating and among the major causes of death in world. Antibiotics have offered humans a new approach to infection control. reckoned as “magic bullets” for fight against bacterial infections, therefore increasing life expectancy decreasing mortality morbidity. However, overuse antibiotics has resulted persistent growth resistant pathogens. New antimicrobial approaches pathogens being examined. Mushrooms seem be promising, possibly more efficient, alternative method that conventional antimicrobials. This work aimed investigate phytochemical constituents potential ethanolic, aqueous, dual solvent extracts mushroom Ganoderma lucidum. Methods: The studies were carried out broth dilution Gram-positive Staphylococcus aureus Gram-negative Escherichia coli. present research was also examine genomic changes associated with G. lucidum S. E. Results: Our data quantitatively showed all found exhibit various degrees effects coli where ethanolic extract exhibited most potent activity. SEM images untreated cells normal cell characteristics while, after treatment lucidum, appeared damaged irregular surfaces wall defacement. results HPLC analysis aqueous consisted beta[1-3] glucans, ganoderic acid, triterpenoids. Genomic identified selective sweeps several genes growth, biosynthesis transport, stress. Conclusions: study concludes three solvents activity infectious causing morphological acquisition mutations genes. Therefore, may candidates preventing future. is reliable source agent can used diseases.

Language: Английский

Citations

0