Investigating the role of KARS in lung adenocarcinoma via single-cell RNA sequencing DOI Creative Commons

Huafang Hu,

Yan Zhong,

G Li

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 3, 2024

Lung Adenocarcinoma (LUAD) is one of the leading causes to cancer-related deaths worldwide and exhibited extensive molecular diversity in its cellular components. In summary, this study examined expression function KARS various LUAD cell populations using single-cell RNA sequencing (scRNA-seq) identify prognostic value as well potential implications for therapy. All datasets related were analyzed previous published studies, which was downloaded from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression(GTEx) project Gene Expression Omnibus (GEO). We subsequently sought analyze association between either clinically tumorigenic or low survival-grade expression, respectively with varied clinicopathological features all patients OS. Verification performed by vitro RT-PCR. Our investigation found that markedly elevated tissue samples compared normal controls. Genomic analysis indicated a robust increased copy number gene overexpression. upregulation also correlated distinct genetic mutations higher mutational load LUAD. heightened activity implicated progression. Furthermore, our research significant interplay KARS's role tumor's immune microenvironment, along dimensions tumor immunology landscape. Comprehensive assessments within microenvironment uncovered pronounced link responses presence specific types. A549 line than 16HBE line. Utilizing omics technologies, offers detailed perspective on LUAD, highlighting biomarker candidate tailored therapeutic intervention. Future should probe possible strategies could target pathologically relevant manner.

Language: Английский

Wind power plant site selection problem solution using GIS and resource assessment and analysis of wind energy potential by estimating Weibull distribution function for sustainable energy production: The case of Bitlis/Turkey DOI Creative Commons
Sabır Rüstemli,

Omer Güntas,

Gökhan Şahin

et al.

Energy Strategy Reviews, Journal Year: 2024, Volume and Issue: 56, P. 101552 - 101552

Published: Oct. 15, 2024

Language: Английский

Citations

4
A Novel Approach for Photovoltaic Plant Site Selection in Megacities Utilizing Power Load Forecasting and Fuzzy Inference System DOI

Rasoul Jalalifar,

M. R. Delavar,

S.F. Ghaderi

et al.

Renewable Energy, Journal Year: 2025, Volume and Issue: unknown, P. 122527 - 122527

Published: Jan. 1, 2025

Language: Английский

Citations

0
Optimum solar power usage as an off-grid/on-grid energy-security alternative for the state of Mizoram in India DOI

V. Stephen Beihropathai,

H. Lalchhandama,

Pradeep Das

et al.

Electrical Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Evaluating site selection for optimal photovoltaic installations and CO₂ emission reduction in selected districts of khyber pakhtunkhwa DOI Creative Commons

Farnaz,

Narissara Nuthammachot, Rabia Shabbir

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

Abstract As the global market for renewable energy solutions expands, geospatial analysis is becoming crucial optimizing solar potential. The current study assesses suitability of installing PV system in Mardan, Peshawar, and Nowshera districts Pakistan using a multi-criteria decision-making (MCDM) approach. Analysis different parameters, such as topography, land use cover (LULC), radiation surface temperature (LST), were performed to find appropriate locations their respective regions. employed binary classification weighted overlay methods detect patterns spatial suitability. Peshawar showed maximum ability with 859.8 km² categorized favorable projected annual power output capacity 67.77 trillion kWh decrease CO₂ emission 2.78 billion metric tons. Mardan closely followed suitable area 828.4 generation 39.74 kWh/year reduction emissions by 1.63 has an 503.0 km², 670.06 kWh, 27.46 million These results underline importance combining meteorological data accurate planning systems. By highlighting location-specific features, including topography irradiance illustrates tailoring outputs environmental impacts local contexts. insights help guide policymakers driving projects, support Pakistan’s sustainable development climate targets.

Language: Английский

Citations

0
Geographical Information System-based methodologies for energy planning: Optimizing site selection for renewable energy plants DOI
María del Pilar Díaz Cuevas, Belén Pérez-Pérez, Paula Ferreira

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Rüzgâr Enerji Santrallerinin Kuruluş Yeri Seçiminde CBS, Çok Kriterli Karar Verme Analizi ve Bulanık Mantık Yönteminin Kullanılması: Kastamonu ili Örneği DOI
Bekir Taştan,

Emin Ziya Bozkan

Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Journal Year: 2025, Volume and Issue: 30(1), P. 172 - 190

Published: April 28, 2025

İnsan nüfusunun hızla artması birçok problemi ortaya çıkarmaktadır. Bu problemlerden birisi temiz, ucuz ve yenilenebilir enerji kaynaklarına olan erişimdir. Rüzgâr gücünün dünyanın hemen her yerinde bulunması erişiminin de diğer göre daha kolay olması bu kaynağa talebi artırmaktadır. karşılayabilmek için santral kurulumuna uygun yerleri tespit edebilecek araştırmalara ihtiyaç duyulmaktadır. çalışmada Kastamonu İl’inde çok kriterli karar verme analizlerinden AHP bulanık mantık yöntemleri kullanarak rüzgâr santrali (RES) kurulumu yer seçimi analizi gerçekleştirilmiştir. Parametrelerin birbirine önem derecelerinin belirlenmesinde yöntemi kullanılmıştır. Sonrasında çalışma sahasının niteliklerine RES kurulum yeri şartlarına parametre alt sınıfları oluşturulmuş yeniden sınıflandırılmıştır. Ağırlıklandırılan sınıflarına üyelik değerleri atanmıştır. Ağırlıklı çakıştırma hem Sonuçta iki farklı uygunluk değer haritası üretilmiştir. Araştırmadan elde edilen bulgulara İl’inin ilin kuzeyinde yoğunlaşmaktadır. Cide, Doğanyurt, Devrekani, Bozkurt Pınarbaşı ilçelerinde yerler bulunmaktadır. Çalışmadan sonuçlar enerjisi potansiyeli (REPA) ile karşılaştırılmıştır. Elde sonuçların REPA atlasındaki bulgularla büyük ölçüde benzerlik gösterdiği belirlenmiştir. Çalışma alanı analizinde yönteminin kullanılmasının literatüre katkı sunacağı kanaatindeyiz.

Citations

0
Assessment of Wind Energy Potential and Optimal Site Selection for Wind Energy Plant Installations in Igdir/Turkey DOI Open Access
Gökhan Şahin, Ahmet Koç, Sülem Şenyiğit Doğan

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(20), P. 8775 - 8775

Published: Oct. 11, 2024

Wind energy is an eco-friendly, renewable, domestic, and infinite resource. These factors render the construction of wind turbines appealing to nations, prompting numerous governments implement incentives augment their installed capacity turbines. Alongside augmenting turbines, identifying suitable locations for installation crucial optimizing turbine performance. This study aims evaluate potential sites power plant via a GIS, mapping technique. The Analytic Hierarchy Process (AHP) was employed assess locations, including both quantitative qualitative aspects that significantly impact farm suitability map. Utilizing GIS methodology, all datasets were examined through height raster transformations land surface temperature, density index, air pressure, humidity, speed, cover, solar radiation, aspect, slope, topographical characteristics, resulting in creation correlation between five-year meteorological data environmental parameters (wind direction, daily maximum minimum temperatures, relative average radiation duration, cloud pressure) influencing Iğdır province, Airport, Karakoyunlu, Aralık, Tuzluca districts, analyzed. If towers are at 1 km intervals across area roughly 858,180 hectares Igdir estimated GWh can be generated. GIS-derived map indicates plants located regions susceptible erosion.

Language: Английский

Citations

1
Balancing Sustainability and Decision Maker Preferences in Regional Development Location Selection: A Multi-criteria Approach Using AHP and Fuzzy Goal Programming DOI Creative Commons

Parapat Gultom,

Esther Sorta Mauli Nababan,

Mardiningsih Mardiningsih

et al.

Mathematical Modelling and Engineering Problems, Journal Year: 2024, Volume and Issue: 11(7), P. 1802 - 1812

Published: July 30, 2024

In this study, we address the challenge of balancing sustainability and decision-maker preferences in regional development location selections.We propose a multi-criteria decision-making framework combining Analytical Hierarchy Process (AHP) Fuzzy Goal Programming (FGP) to evaluate potential sites.AHP is utilized prioritize criteria, incorporating both quantitative qualitative factors, while FGP allows for accommodation uncertainty conflicting goals.Our findings reveal that integrated approach provides robust, systematic method identifying optimal locations align with goals stakeholder priorities.The analysis revealed following satisfaction levels: Price 61.11%, Quality 80.4%, Delivery Time 79.3%, Carbon Emission 91.76%, Preference 51.18%.The emphasize complex process selecting vendors within palm oil supply chain.The implications research suggest enhanced efficiency effectiveness planning, promoting sustainable practices.

Language: Английский

Citations

0
Investigating the role of KARS in lung adenocarcinoma via single-cell RNA sequencing DOI Creative Commons

Huafang Hu,

Yan Zhong,

G Li

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 3, 2024

Lung Adenocarcinoma (LUAD) is one of the leading causes to cancer-related deaths worldwide and exhibited extensive molecular diversity in its cellular components. In summary, this study examined expression function KARS various LUAD cell populations using single-cell RNA sequencing (scRNA-seq) identify prognostic value as well potential implications for therapy. All datasets related were analyzed previous published studies, which was downloaded from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression(GTEx) project Gene Expression Omnibus (GEO). We subsequently sought analyze association between either clinically tumorigenic or low survival-grade expression, respectively with varied clinicopathological features all patients OS. Verification performed by vitro RT-PCR. Our investigation found that markedly elevated tissue samples compared normal controls. Genomic analysis indicated a robust increased copy number gene overexpression. upregulation also correlated distinct genetic mutations higher mutational load LUAD. heightened activity implicated progression. Furthermore, our research significant interplay KARS's role tumor's immune microenvironment, along dimensions tumor immunology landscape. Comprehensive assessments within microenvironment uncovered pronounced link responses presence specific types. A549 line than 16HBE line. Utilizing omics technologies, offers detailed perspective on LUAD, highlighting biomarker candidate tailored therapeutic intervention. Future should probe possible strategies could target pathologically relevant manner.

Language: Английский

Citations

0