Correlation of neutrophil percentage-to-albumin ratio with lung function in American adults: a population study

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 21, 2025

Chronic respiratory diseases pose a significant threat to global health, underscoring the urgent need for effective preventative and therapeutic interventions. The neutrophil-to-albumin ratio (NPAR), an emerging biomarker inflammation nutritional status, has shown promising associations with necessitating investigation into its potential predicting lung function decline. This study aimed delineate relationship between NPAR pulmonary within sample of American adult population assess viability as prognostic indicator compromised function. With data available from National Health Nutrition Examination Survey (NHANES) years 2007 2012, 10,055 adults who met exclusion criteria were included in current study. Multivariate linear regression, smoothed curve fitting, subgroup analyses applied evaluate observed indicators. Even after accounting all confounding factors, inverse persisted key indicators, including forced expiratory volume one second (FEV1), vital capacity (FVC), peak flow rate (PEF). association remained robust even factors considered. Subgroup analysis revealed that negative correlation was more pronounced certain demographic groups, such young individuals, males, smokers. also "N-shaped" fractional exhaled nitric oxide (FENO), suggesting may play role promoting airway inflammation. A decline among this research, emphasizing clinical relevance health biomarker, well importance considering systemic management prevention disorders.

Language: Английский

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Evaluation of Novel Combined CBC‐Derived Systemic Inflammatory Ratios and Their Dynamic Changes as ICU Mortality Predictors, a Retrospective Cohort

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(3)

Published: March 1, 2025

Novel biomarkers, such as neutrophil lymphocyte ratio, monocyte to platelet derived systemic immune-inflammation index, inflammation response and aggregate index of inflammation, have shown promising prognostic value, especially in ICU settings. We aimed evaluate the potential mentioned factors mortality predictors a heterogeneous cohort. conducted retrospective cohort study using data obtained from intensive care unit (ICU) records 311 patients. evaluated strength inflammatory parameters upon admission, 48 h later, their dynamic changes within this period predicting mortality. used multivariate logistic regression with backward elimination, which were further validated ROC calibration curves. Interaction terms added assess possible modifications predictive performance ratios across various subgroups NLPR, post admission (p < 0.001, OR: 7.3436, 95% CI: 3.2986-17.2619) NLPR during first = 0.018, 2.3826, 1.2069-6.7112), significant models. The model, including 48-h had highest AUC ROC, slope, lowest AIC (0.8671, 0.8622, 229.12, respectively). Also, decreases significantly among patients background CVA. level, post-ICU its stay, predict critically ill These findings can serve practical accessible mortality, particularly settings, where traditional scoring systems may not be routinely available.

Language: Английский

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Multi-Indicator analysis of the impact of preoperative inflammatory states on complications following pancreatoduodenectomy

Langenbeck s Archives of Surgery, Journal Year: 2025, Volume and Issue: 410(1)

Published: March 31, 2025

Pancreatoduodenectomy (PD) is a complex surgery with high rate of postoperative complications, for which effective preoperative indicators are currently lacking. Inflammatory indices such as the pan-immune-inflammation value (PIV), platelet-neutrophil product (PPN), and platelet-albumin ratio (PAR) have shown potential biomarkers prognosis in various cancers. However, their predictive complications open-PD (OPD) patients remains underexplored. This study aims to investigate relationship between these inflammatory identify new biomarkers, provide theoretical basis improving perioperative management OPD patients. We analyzed data from 309 who underwent (OPD). Six indices-platelet-to-lymphocyte (PLR), PIV, PPN, PAR, neutrophil-to-HDL (NHR), neutrophil-albumin (NAR)-were assessed association using logistic regression restricted cubic spline analysis. Predictive performance was evaluated ROC curves decision curve PLR, PPN were significantly linked most outcomes had good performance. NHR associated severe complications. PAR effectively predicted hemorrhage (AUC = 0.684) delayed gastric emptying (DGE) 0.701). Combining enhanced accuracy. key patients, also useful predicting like DGE.

Language: Английский

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Mortality Predictors in Patients with Severe COPD Exacerbation

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3028 - 3028

Published: April 27, 2025

Background: Severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a leading cause intensive care unit (ICU) admissions and in-hospital mortality. Several hematological inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), derived NLR (dNLR), systemic immune-inflammation index (SII), have been proposed as markers severity Methods: A retrospective study was conducted on 104 ICU patients with AECOPD over two-year period. We collected analyzed clinical, demographic, laboratory data. The indices the two groups—survivors (n = 39) non-survivors 65)—were compared to assess differences. used t-tests, ANOVA, chi-square tests, Mann–Whitney U tests compare groups. factors that independently predicted mortality were identified using multivariate logistic regression. examined survival differences Kaplan–Meier analysis, ROC curves utilized evaluate predictive power each biomarker. Results: Mortality substantially by higher SII (OR: 1.92, 95% CI: 1.24–3.08, p 0.002) 2.89, 1.72–4.82, < 0.001). Patients > 8.0 1800 had significantly lower rates (log-rank 0.001), according analysis. (AUC 0.79) 0.82) best predictors death, Conclusions: In ICU-admitted patients, NLR, MLR, PLR, dNLR, independent Due their ease evaluation capabilities, they should be included in risk models for early interventions.

Language: Английский

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The prognostic value of systemic immune-inflammation index and lymphocyte-to-monocyte ratio in cases with profound sudden sensorineural hearing loss

American Journal of Otolaryngology, Journal Year: 2025, Volume and Issue: unknown, P. 104671 - 104671

Published: May 1, 2025

Language: Английский

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Ethylene oxide exposure, inflammatory indicators, and depressive symptoms: a cross-sectional study and mediation analysis based on a non-institutionalized American population

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 2, 2024

Ethylene oxide (EO) is a volatile compound positively correlated with respiratory and cardiovascular diseases. Currently, evidence suggests that environmental exposure may contribute to depressive symptoms. This study evaluated the correlation between EO symptoms investigated whether inflammatory indicators had mediation effect on this correlation. Patients were enrolled from National Health Nutrition Examination Survey during 2013-2016, 2,764 (49.67% male 50.33% female) participants ultimately included. was determined by measuring hemoglobin-EO adduct (Hb-EO) concentration due its long half-life, which log2-transformed. Depressive assessed using Patient Questionnaire-9. Multivariable logistic regression analysis performed identify any correlations before after covariate adjustment. Sensitivity analysis, subgroup analyses, interaction tests further evaluate identified correlations. Mediation conducted reveal specific mediated A high prevalence of observed in quartiles increased levels exposure, individuals exhibiting higher Hb-EO than female individuals. positive (odds ratio [OR]: 1.439, 95% confidence interval [CI]: 1.310, 1.581), remained stable even adjustment (OR: 1.332, CI: 1.148, 1.545). Interaction showed significant effects sex (p < 0.001) thyroid diseases = 0.048) In white blood cell 0.010) neutrophil counts exerted mediating effect, accounting for 13.6 11.9%, respectively. Increased associated an elevated risk symptoms, where exert effect. Further prospective studies are required investigate potential link among EO, other pollutants, human mental health.

Language: Английский

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