
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 15, 2024
Background Regulated cell death (RCD) is a genetically controlled form of that plays an important role in organogenesis, tissue remodeling, and pathogenesis cancers. Transforming growth factor-beta-activation kinase 1 (TAK1) member the serine/threonine protein family, which can respond to internal external stimuli participate inflammatory responses through multiple signaling pathways cellular processes. In last two decades, regulatory roles TAK1 at crossroads RCD pathways, including apoptosis, necroptosis, pyroptosis, PANoptosis were revealed by 801 articles retrieved from Web Science Core Collection database. To analyze global research trends hotspots concerning RCD, bibliometric visualized analysis applied current study. Methods The data for this bibliometrics study search formula was (TS=(Apoptosis) OR TS=(pyroptosis) TS=(Necroptosis) TS=(PANoptosis) TS=(Autophagy) TS=(Ferroptosis) TS=(cuproptosis)) AND ((TS=(TAK1)) TS=(MAP3K7)). co-occurrence co-cited on basic parameters conducted VOSviewer. dual-map overlay journals, citation bursts, keyword timelines, bursts analyzed CiteSpace. Results A total 46 countries have been included analysis. number publications demonstrates consistent increase 1999 2024. primary institutions driving field are Osaka University Notably, Journal Biological Chemistry stands out as most popular journal domain. These collectively involve contributions 4663 authors, with Jun Tsuji emerging prolific author. also gains highest co-citation frequency. Emerging encapsulated keywords, NF-κB, inflammation, autophagy, TNFα. Conclusion This first RCD. Based articles, results provide retrospective comprehensive view frontiers propose ideas guiding their future investigations molecular mechanisms therapeutic strategies field.
Language: Английский