Copper Nanoparticle Loaded Electrospun Patches for Infected Wound Treatment: From Development to In-Vivo Application DOI Open Access
Anna Butsyk, Yuliia Varava, Roman Moskalenko

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2733 - 2733

Published: Sept. 27, 2024

This study investigates the development and application of electrospun wound dressings based on polylactic acid (PLA) nanofibers, chitosan, copper nanoparticles (CuNPs) for treatment purulent skin wounds. The materials were evaluated their structural, antibacterial, healing properties using an animal model. PLA/Ch-CuNPs demonstrated most significant antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, surpassing other tested materials. integration CuNPs into nanofiber matrices not only enhanced antimicrobial efficacy but also maintained structural integrity biocompatibility dressings. In vivo experiments a rat model showed that facilitated faster with reduced exudative inflammatory responses compared to PLA alone or PLA-CuNPs. Histological immunohistochemical assessments revealed combination PLA, mitigated processes promoted tissue regeneration more effectively. However, this identified potential toxicity related ions, emphasizing need careful optimization CuNP concentrations. These findings suggest could serve as potent, cost-effective dressing broad-spectrum properties, addressing challenge antibiotic-resistant infections enhancing outcomes.

Language: Английский

Valorization of hazardous leather shaving dust for the fabrication of electrospun collagen/PVA/chitosan nanomats in wound care DOI Creative Commons

Fatema Tujjohra,

Md. Mazharul Islam, Taslim Ur Rashid

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100748 - 100748

Published: March 1, 2025

Language: Английский

Citations

0
Formulation and Evaluation of Licorice-Extract-Enhanced Chitosan, PVA, and Gelatin-Derived Hydrogels for Wound Dressing DOI Creative Commons

Maria Mujahid,

Muhammad Zubair, Asma Yaqoob

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 439 - 439

Published: April 23, 2025

Wound infections remain a significant clinical challenge, impeding healing and causing deterioration. Recently, multifunctional hydrogel dressings have gained interest as an effective treatment to treat efficiently enhance wound recovery. The present research is focused on the development of composite hydrogels comprising chitosan (CS), polyvinyl alcohol (PVA), gelatin (GEL) licorice extract (LE), using freeze gelation technique. resulting CS/PVA/GEL incorporating LE were characterized by FTIR, XRD SEM. FTIR analysis confirmed presence specific functional groups within molecules. exhibited amorphous nature hydrogels. SEM revealed that increasing CS ratio in created more porous structure with smaller pore size. All demonstrated oxygen permeability, which crucial for process. Among synthesized hydrogels, MM-2 containing PVA (20 mL) (4 superior performance water retention capacity 440% moisture content 91%. This exceptional result can be attributed higher proportion material’s structure, enhances its hydrophilic properties. showed good antibacterial potential against three selected strains bacteria including Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus) Escherichia coli (E. coli). hydrogels’ cytotoxicity levels assessed through hemolysis assay results all non-toxic. hydrolytic breakdown interconnected components slow degradation, making them appropriate long-term treatment. Specifically, MM-4 74% degradation rate displayed 75% antioxidant activity, indicating effectiveness chronic applications. These characteristics CS/PVA/GEL/LE-derived suggest their use promising candidate care

Language: Английский

Citations

0
Coaxial Electrospun wound dressing integrated with Ag-Doped Hydroxyapatite For Wound healing: Tetracycline delivery DOI

Kosar Pirzadeh,

Leila Torkian, Maryam Daghighi Asli

et al.

Materials Today Communications, Journal Year: 2024, Volume and Issue: unknown, P. 110439 - 110439

Published: Oct. 1, 2024

Language: Английский

Citations

1
Copper Nanoparticle Loaded Electrospun Patches for Infected Wound Treatment: From Development to In-Vivo Application DOI Open Access
Anna Butsyk, Yuliia Varava, Roman Moskalenko

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2733 - 2733

Published: Sept. 27, 2024

This study investigates the development and application of electrospun wound dressings based on polylactic acid (PLA) nanofibers, chitosan, copper nanoparticles (CuNPs) for treatment purulent skin wounds. The materials were evaluated their structural, antibacterial, healing properties using an animal model. PLA/Ch-CuNPs demonstrated most significant antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, surpassing other tested materials. integration CuNPs into nanofiber matrices not only enhanced antimicrobial efficacy but also maintained structural integrity biocompatibility dressings. In vivo experiments a rat model showed that facilitated faster with reduced exudative inflammatory responses compared to PLA alone or PLA-CuNPs. Histological immunohistochemical assessments revealed combination PLA, mitigated processes promoted tissue regeneration more effectively. However, this identified potential toxicity related ions, emphasizing need careful optimization CuNP concentrations. These findings suggest could serve as potent, cost-effective dressing broad-spectrum properties, addressing challenge antibiotic-resistant infections enhancing outcomes.

Language: Английский

Citations

0